Efficient, stereoselective synthesis of 24(S),25-epoxycholesterol
Tomkinson, Nicholas C. O. and Willson, Timothy M. and Russel, Jonathon S. and Spencer, Thomas A. (1998) Efficient, stereoselective synthesis of 24(S),25-epoxycholesterol. Journal of Organic Chemistry, 63 (26). pp. 9919-9923. ISSN 0022-3263 (https://doi.org/10.1021/JO981753V)
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Efficient, stereoselective syntheses of 24(S),25-epoxycholesterol (I) have been developed starting from cholenic acid or stigmasterol, both featuring as the key step Sharpless asym. dihydroxylation of desmosterol acetate. This work permits prepn. of gram quantities of I for further evaluation as a natural regulator of cholesterol metab., specifically, e.g., as a ligand for the LXRα nuclear receptor.
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Item type: Article ID code: 34217 Dates: DateEvent1998PublishedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 20 Oct 2011 15:24 Last modified: 08 Apr 2024 19:29 URI: https://strathprints.strath.ac.uk/id/eprint/34217
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