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Number of items: 196.

2021

Almeida, Afonso R M and Neto, João L and Cachucho, Ana and Euzébio, Mayara and Meng, Xiangyu and Kim, Rathana and Fernandes, Marta B and Raposo, Beatriz and Oliveira, Mariana L and Ribeiro, Daniel and Fragoso, Rita and Zenatti, Priscila P and Soares, Tiago and de Matos, Mafalda R and Corrêa, Juliana Ronchi and Duque, Mafalda and Roberts, Kathryn G and Gu, Zhaohui and Qu, Chunxu and Pereira, Clara and Pyne, Susan and Pyne, Nigel J and Barreto, Vasco M and Bernard-Pierrot, Isabelle and Clappier, Emannuelle and Mullighan, Charles G and Grosso, Ana R and Yunes, J Andrés and Barata, João T (2021) Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia. Nature Communications, 12 (1). 7268. ISSN 2041-1723

Alsanafi, Mariam and Brown, Ryan D. R. and Oh, Jeongah and Adams, David R. and Torta, Federico and Pyne, Nigel J. and Pyne, Susan (2021) Dihydroceramide desaturase functions as an inducer and rectifier of apoptosis : effect of retinol derivatives, antioxidants and phenolic compounds. Cell Biochemistry and Biophysics, 79 (3). pp. 461-475. ISSN 1085-9195

Brown, Ryan D.R. and Veerman, Ben E.P. and Oh, Jeongah and Tate, Rothwelle J. and Torta, Federico and Cunningham, Margaret R. and Adams, David R. and Pyne, Susan and Pyne, Nigel J. (2021) A new model for regulation of sphingosine kinase 1 translocation to the plasma membrane in breast cancer cells. Journal of Biological Chemistry. 100674. ISSN 1083-351X

Schwalm, Stephanie and Beyer, Sandra and Hafizi, Redona and Traufmann, Sandra and Geisslinger, Gerd and Adams, David R. and Pyne, Susan and Pyne, Nigel and Schaefer, Liliana and Huwiler, Andrea and Pfeilschifter, Josef (2021) Validation of highly selective Sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis. Cellular Signalling, 79. 109881. ISSN 1873-3913

2020

Adams, David R. and Pyne, Susan and Pyne, Nigel J. (2020) Structure-function analysis of lipid substrates and inhibitors of sphingosine kinases. Cellular Signalling, 76. 109806. ISSN 1873-3913

Pyne, Nigel J. and Pyne, Susan (2020) Recent advances in the role of Sphingosine 1-phosphate in cancer. FEBS Letters, 594 (22). pp. 3583-3601. ISSN 0014-5793

Shin, Sun-Hye and Kim, Hee-Yeon and Yoon, Hee-Soo and Park, Woo-Jae and Adams, David R and Pyne, Nigel J. and Pyne, Susan and Park, Joo-Won (2020) A novel selective sphingosine kinase 2 inhibitor, HWG-35D, ameliorates the severity of imiquimod-induced psoriasis model by blocking Th17 differentiation of naïve CD4 T lymphocytes. International Journal of Molecular Sciences, 21 (21). 8371. ISSN 1422-0067

Alsanafi, Mariam and Kelly, Samuel L. and McNaughton, Melissa and Merrill Jr., Alfred H. and Pyne, Nigel J. and Pyne, Susan (2020) The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 1865 (4). 158631. ISSN 1388-1981

Pyne, Susan and Adams, David R. and Pyne, Nigel J.; Gomez-Cambronero, Julian and Frohman, Michael A., eds. (2020) Sphingosine kinases as druggable targets. In: Lipid Signaling in Human Diseases. Springer Berlin Heidelberg, Cham, Switzerland, pp. 49-76. ISBN 978-3-030-33668-4

Hii, Ling-Wei and Chung, Felicia Fei-Lei and Mai, Chun Wai and Yee, Zong Yang and Chan, Hong Hao and Raja, Vijay Joseph and Dephoure, Noah Elias and Pyne, Nigel J. and Pyne, Susan and Leong, Chee-Onn (2020) Sphingosine kinase 1 regulates the survival of breast cancer stem cells and non-stem breast cancer cells by suppression of STAT1. Cells, 9 (4). 886. ISSN 2073-4409

2019

Alganga, Husman and Almabrouk, Tarek A. M. and Katwan, Omar J. and Daly, Craig J. and Pyne, Susan and Pyne, Nigel J. and Kennedy, Simon (2019) Short periods of hypoxia upregulate Sphingosine Kinase 1 and increase vasodilation of arteries to Sphingosine 1-Phosphate via S1P3. Journal of Pharmacology and Experimental Therapeutics, 371 (1). pp. 63-74. ISSN 0022-3565

Pyne, Nigel J and Pyne, Susan (2019) Sphingosine 1-phosphate turnover (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE, 2019 (4). ISSN 2633-1020

Omar, Faisa and Findlay, Jane E. and Carfray, Gemma and Allcock, Robert W. and Jiang, Zhong and Moore, Caitlin and Muir, Amy L. and Lannoy, Morgane and Fertig, Bracy A. and Mai, Deborah and Day, Jonathan P. and Bolger, Graeme and Baillie, George S. and Schwiebert, Erik and Klussmann, Enno and Pyne, Nigel J. and Ong, Albert C.M. and Bowers, Keith and Adam, Julia M. and Adams, David R. and Houslay, Miles D. and Henderson, David J. P. (2019) Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases. Proceedings of the National Academy of Sciences of the United States of America, 116 (27). pp. 13320-13329. ISSN 0027-8424

Fang, Zijian and Pyne, Susan and Pyne, Nigel J. (2019) Ceramide and sphingosine 1-phosphate in adipose dysfunction. Progress in Lipid Research, 74. pp. 145-159. ISSN 0163-7827

Adams, David R. and Tawati, Salha and Berretta, Giacomo and Rivas, Paula Lopez and Baiget, Jessica and Jiang, Zhong and Alsfouk, Aisha and MacKay, Simon P. and Pyne, Nigel J. and Pyne, Susan (2019) Topographical mapping of isoform-selectivity determinants for J-channel-binding inhibitors of sphingosine kinases 1 and 2. Journal of Medicinal Chemistry, 62 (7). pp. 3658-3676. ISSN 0022-2623

Greig, Fiona H. and Nader, Katrin and Ballantyne, Margaret D. and Kazi, Zeshan H. and Alganga, Husam and Ewart, Marie-Ann and Zaborska, Karolina E. and Fertig, Bracy and Pyne, Nigel J. and Pyne, Susan and Kennedy, Simon (2019) Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse. European Journal of Pharmacology, 842. pp. 1-9. ISSN 0014-2999

2018

Alsanafi, Mariam and Kelly, Samuel L. and Jubair, Karawan and McNaughton, Melissa and Tate, Rothwelle J. and Merrill Jr., Alfred H. and Pyne, Susan and Pyne, Nigel J. (2018) Native and polyubiquitinated forms of dihydroceramide desaturase are differentially linked to human embryonic kidney cell survival. Molecular and Cellular Biology, 38. e00222. ISSN 0270-7306

Pyne, Nigel J. and Pyne, Susan (2018) Does the sphingosine 1-phosphate receptor-1 provide a better or worse prognostic outcome for breast cancer patients? Frontiers in Oncology, 8 (417). pp. 1-3. ISSN 2234-943X

El Buri, Ashref and Adams, David R. and Smith, Douglas and Tate, Rothwelle J. and Mullin, Margaret and Pyne, Susan and Pyne, Nigel J. (2018) The sphingosine 1-phosphate receptor 2 is shed in exosomes from breast cancer cells and is N-terminally processed to a short constitutively active form that promotes extracellular signal regulated kinase activation and DNA synthesis in fibroblasts. Oncotarget, 9 (50). pp. 29453-29467. ISSN 1949-2553

Pyne, Nigel J. and El Buri, Ashref and Adams, David R. and Pyne, Susan (2018) Sphingosine 1-phosphate and cancer. Advances in Biological Regulation, 68. pp. 97-106. ISSN 2212-4934

Shukla, Arun K. and Pyne, Nigel J. (2018) Cellular Signalling – Special issue to celebrate 75th birthday of Prof. Robert J. Lefkowitz. Cellular Signalling, 41. p. 1. ISSN 1873-3913

2017

Pyne, Nigel J. and Pyne, Susan (2017) Sphingosine kinase1 : a potential therapeutic target in pulmonary arterial hypertension? Trends in Molecular Medicine, 23 (9). pp. 786-798. ISSN 1471-4914

Pyne, Nigel J. and Adams, David R. and Pyne, Susan (2017) Sphingosine kinase 2 in autoimmune/inflammatory disease and development of sphingosine kinase 2 inhibitors. Trends in Pharmacological Sciences, 38 (7). pp. 581-591. ISSN 0165-6147

Pyne, Nigel J. and Pyne, Susan (2017) Sphingosine kinase 2 and multiple myeloma. Oncotarget, 8 (24). pp. 43596-43597. 17420. ISSN 1949-2553

Pyne, Nigel J. and Pyne, Susan (2017) Sphingosine 1-phosphate receptor 1 signaling in mammalian cells. Molecules, 22 (3). pp. 1-18. 344. ISSN 1420-3049

Barbour, Mark and McNaughton, Melissa and Boomkamp, Stephanie D. and MacRitchie, Neil and Jiang, Hui-Rong and Pyne, Nigel J and Pyne, Susan (2017) Effect of sphingosine kinase modulators on interleukin-1β release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis : FTY720 analogues and inflammation. British Journal of Pharmacology, 174 (2). pp. 210-222. ISSN 1476-5381

2016

Evangelisti, C and Evangelisti, C and Buontempo, F and Lonetti, A and Orsini, E and Chiarini, F and Barata, J T and Pyne, S and Pyne, N J and Martelli, A M (2016) Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies. Leukemia, 30. 2142–2151. ISSN 0887-6924

MacRitchie, Neil and Volpert, Giora and Al Washih, Mohammed and Watson, David G. and Futerman, Anthony H. and Kennedy, Simon and Pyne, Susan and Pyne, Nigel J. (2016) Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodeling in a hypoxic model of pulmonary arterial hypertension. Cellular Signalling, 28 (8). pp. 946-955. ISSN 1873-3913

Adams, David R. and Pyne, Susan and Pyne, Nigel J. (2016) Sphingosine kinases : emerging structure function insights. Trends in Biochemical Sciences, 41 (5). pp. 395-409. ISSN 0968-0004

Pyne, Susan and Adams, David R and Pyne, Nigel J. (2016) Sphingosine 1-phosphate and sphingosine kinases in health and disease : recent advances. Progress in Lipid Research, 62. pp. 93-106. ISSN 0163-7827

McNaughton, Melissa and Pitman, Melissa and Pitson, Stuart M. and Pyne, Nigel J. and Pyne, Susan (2016) Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells. Oncotarget, 7. pp. 16663-16675.

Boomkamp, Stephanie D. and Byun, Hoe-Sup and Ubhi, Satvir and Jiang, Hui-Rong and Pyne, Susan and Bittman, Robert and Pyne, Nigel J. (2016) Effect of ether glycerol lipids on interleukin-1β release and experimental autoimmune encephalomyelitis. Chemistry and Physics of Lipids, 194. pp. 2-11. ISSN 0009-3084

Pyne, Nigel J. and McNaughton, Melissa and Boomkamp, Stephanie and MacRitchie, Neil and Evangelisti, Cecilia and Martelli, Alberto M. and Jiang, Hui-Rong and Ubhi, Satvir Kaur and Pyne, Susan (2016) Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation. Advances in Biological Regulation, 60. pp. 151-159. ISSN 2212-4934

Pyne, Nigel J. and Tigyi, Gabor J. (2016) A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research. Progress in Lipid Research, 61. pp. 19-29. 61. ISSN 0163-7827

2015

Pyne, Nigel J. and Kolesnick, Richard N. (2015) The life and work of Dr Robert Bittman (1942-2014). Biological Chemistry, 396 (6-7). pp. 827-830. ISSN 1431-6730

2014

Wang, Jing and Knapp, Stefan and Pyne, Nigel J. and Pyne, Susan and Elkins, Jonathan M. (2014) Crystal structure of sphingosine kinase 1 with PF-543. Medicinal Chemistry Letters, 5 (12). pp. 1329-1333. ISSN 1948-5875

Lim, Keng Gat and Gray, Alexander I. and Anthony, Nahoum G. and MacKay, Simon P. and Pyne, Susan and Pyne, Nigel J. (2014) Resveratrol and its oligomers : modulation of sphingolipid metabolism and signaling in disease. Archives of Toxicology, 88 (12). pp. 2213-2232. ISSN 0340-5761

Pyne, N J and Pyne, S (2014) Sphingosine kinase 1 enables communication between melanoma cells and fibroblasts that provides a new link to metastasis. Oncogene, 33 (26). pp. 3361-3363. ISSN 0950-9232

Ohotski, Jan and Rosen, Hugh and Bittman, Robert and Pyne, Susan and Pyne, Nigel J (2014) Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth : the role of sphingosine 1-phosphate receptor-4. Cellular Signalling, 26 (5). pp. 1040-1047. ISSN 1873-3913

Pyne, Nigel J and Ohotski, Jan and Bittman, Robert and Pyne, Susan (2014) The role of sphingosine 1-phosphate in inflammation and cancer. Advances in Biological Regulation, 54. pp. 121-129. ISSN 2212-4934

Evangelisti, C and Evangelisti, C and Teti, G and Chiarini, F and Falconi, M and Melchionda, F and Pession, A and Bertaina, A and Locatelli, F and McCubrey, JA and Baek, DJ and Bittman, Robert and Pyne, Susan and Pyne, Nigel and Martelli, AM (2014) Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics. Oncotarget, 5 (17). pp. 7886-7901.

2013

Alexander, Stephen P H and Benson, Helen E and Faccenda, Elena and Pawson, Adam J and Sharman, Joanna L and McGrath, John C and Catterall, William A and Spedding, Michael and Peters, John A and Harmar, Anthony J and Abul-Hasn, N and Anderson, C M and Anderson, C M H and Araiksinen, M S and Arita, M and Arthofer, E and Barker, E L and Barratt, C and Barnes, N M and Bathgate, R and Beart, P M and Belelli, D and Bennett, A J and Birdsall, N J M and Boison, D and Bonner, T I and Brailsford, L and Bröer, S and Brown, P and Calo, G and Carter, W G and Catterall, W A and Chan, S L F and Chao, M V and Chiang, N and Christopoulos, A and Chun, J J and Cidlowski, J and Clapham, D E and Cockcroft, S and Connor, M A and Cox, H M and Cuthbert, A and Dautzenberg, F M and Davenport, A P and Dawson, P A and Jones, R L and Kennedy, C and Pyne, N J and Pyne, S, CGTP Collaborators (2013) The Concise Guide to PHARMACOLOGY 2013/14 : overview. British Journal of Pharmacology, 170 (8). pp. 1449-58. ISSN 1476-5381

Baek, Dong Jae and MacRitchie, Neil and Anthony, Nahoum G and Mackay, Simon P and Pyne, Susan and Pyne, Nigel J and Bittman, Robert (2013) Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors. Journal of Medicinal Chemistry, 56 (22). pp. 9310-9327. ISSN 0022-2623

Rutherford, C and Childs, S and Ohotski, J and McGlynn, L and Riddick, M and MacFarlane, S and Tasker, D and Pyne, S and Pyne, N J and Edwards, J and Palmer, T M (2013) Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1. Cell Death and Disease, 4. e927. ISSN 2041-4889

Byun, Hoe-Sup and Pyne, Susan and Macritchie, Neil and Pyne, Nigel J and Bittman, Robert (2013) Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells. MedChemComm, 4 (10). pp. 1394-1399. ISSN 2040-2503

Liu, Zheng and MacRitchie, Neil and Pyne, Susan and Pyne, Nigel J and Bittman, Robert (2013) Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators. Bioorganic and Medicinal Chemistry, 21 (9). pp. 2503-2510. ISSN 0968-0896

Watson, David G and Tonelli, Francesca and Al Osaimi, Manal and Williamson, Leon and Chan, Edmond and Gorshkova, Irina and Berdyshev, Evgeny and Bittman, Robert and Pyne, Nigel J and Pyne, Susan (2013) The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. Cellular Signalling, 25 (4). pp. 1011-1017. ISSN 1873-3913

Pyne, Susan and Pyne, Nigel; Gulbins, Erich and Petrache, Irina, eds. (2013) New perspectives on the role of sphingosine 1-phosphate in cancer. In: Sphingolipids in Disease. Handbook of experimental pharmacology . Springer-Verlag, Vienna, pp. 55-71. ISBN 9783709115107

Tonelli, F. and Alossaimi, M. and Williamson, L. and Tate, R.J. and Watson, D.G. and Chan, E. and Bittman, R. and Pyne, N.J. and Pyne, S. (2013) The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism. British Journal of Pharmacology, 168 (6). pp. 1497-1505. ISSN 1476-5381

Gibriel, Abdullah and Tate, Rothwelle and Yu, Yongbin and Rawson-Lax, E. and Hammer, HM and Tettey, Justice Nii Addy and Pyne, Nigel and Converse, Carolyn (2013) The p.Arg86Gln change in GARP2 (glutamic acid-rich protein-2) is a common West African-related polymorphism. Gene, 515 (1). pp. 155-158. ISSN 0378-1119

OHOTSKI, Jan and Edwards, Joanne and Elsberger, Beatrix and Watson, Carol and Orange, Clare and Mallon, Elizabeth and Pyne, Susan and Pyne, Nigel (2013) Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer. International Journal of Cancer, 132 (3). 605–616. ISSN 0020-7136

Pyne, Susan and Pyne, Nigel (2013) Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer. Cancer Cell, 23 (1). pp. 5-7. ISSN 1878-3686

Pyne, Nigel and Dubois, Gerald and Pyne, Susan (2013) Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 1831 (1). pp. 228-238. ISSN 1388-1981

Baek, Dong Jae and MacRitchie, Neil and Pyne, Nigel and Pyne, Susan and Bittman, Robert (2013) Synthesis of selective inhibitors of sphingosine kinase 1. Chemical Communications (London). ISSN 0009-241X

Tonelli, Francesca and Alossaimi, Manal and Natarajan, Viswanathan and Gorshkova, Irina and Berdyshev, Evgeny and Bittman, Robert and Watson, David G and Pyne, Susan and Pyne, Nigel J (2013) The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells. Biomolecules, 3 (2). pp. 316-333. ISSN 2218-273X

2012

Pyne, Susan and Edwards, Joanne and OHOTSKI, Jan and Pyne, Nigel J. (2012) Sphingosine 1-phosphate receptors and sphingosine kinase 1 : novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers. Frontiers in Oncology, 2. 168.

Pyne, Nigel and Pyne, Susan; Chun, Jerold, ed. (2012) Lysophospholipid receptor signalling platforms : the receptor tyrosine kinase-G-protein coupled receptor signaling complex. In: Lysophospholipid Receptors. John Wiley & Sons Inc., Chichester, pp. 85-102. ISBN 9780470569054

Lim, Keng Gat and Tonelli, Francesca Romana and Berdyshev, Evgeny and Gorshkova, Irina and Leclercq, Tamara and Pitson, Stuart M and Bittman, Robert and Pyne, Susan and Pyne, Nigel (2012) Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells : functional differences between sphingosine kinase 1a and 1b. International Journal of Biochemistry and Cell Biology, 44 (9). pp. 1457-1464. ISSN 1357-2725

Lim, Keng Gat and Gray, Alexander I and Pyne, Susan and Pyne, Nigel J (2012) Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival. British Journal of Pharmacology, 166 (5). pp. 1605-1616. ISSN 1476-5381

Ohotski, Jan and Long, Jaclyn and Orange, Clare and Elsberger, Beatrix and Mallon, Elizabeth and Doughty, J and Pyne, Susan and Pyne, Nigel and Edwards, Joanne (2012) Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer. British Journal of Cancer, 106 (8). pp. 1453-1459. ISSN 1532-1827

Pyne, Nigel J and Tonelli, Francesca and Lim, Keng Gat and Long, Jaclyn and Edwards, Joanne and Pyne, Susan (2012) Targeting sphingosine kinase 1 in cancer. Advances in Biological Regulation, 52 (1). 31–38. ISSN 2212-4934

2011

Lim, Keng Gat and Sun, Chaode and Bittman, Robert and Pyne, Nigel J and Pyne, Susan (2011) (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor : Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. Cellular Signalling, 23 (10). pp. 1590-1595. ISSN 1873-3913

Grzelczyk, A. and Rytczak, P. and Okruszek, A. and Koziolkiewicz, M. and Pyne, N. and Pyne, S. (2011) Cyclic phosphatidic acid and its analogues can regulate ERK1/2 activity via LPA receptors. Chemistry and Physics of Lipids, 164 (Supple). S32. ISSN 0009-3084

Pyne, Nigel J and Pyne, Susan (2011) Receptor tyrosine kinase-G-protein-coupled receptor signalling platforms : out of the shadow? Trends in Pharmacological Sciences, 32 (8). pp. 443-450.

Pyne, Nigel J. and Pyne, Susan (2011) Selectivity and specificity of sphingosine 1-phosphate receptor ligands : "off-targets" or complex pharmacology? Frontiers in Pharmacology, 2. 26.

Lim, Keng and Tonelli, Francesca Romana and Li, Z. and Lu, X. and Bittman, R. and Pyne, Susan and Pyne, Nigel (2011) FTY720 analogues as sphingosine kinase 1 inhibitors : enzyme inhibition kinetics, allosterism, proteasomal degradation and actin rearrangement in MCF-7 breast cancer cells. Journal of Biological Chemistry, 286 (21). pp. 18633-18640. ISSN 1083-351X

Berdyshev, Evgeny V and Gorshkova, Irina and Usatyuk, Peter and Kalari, Satish and Zhao, Yutong and Pyne, Nigel J and Pyne, Susan and Sabbadini, Roger A and Garcia, Joe G.N. and Natarajan, Viswanathan (2011) Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells : role of sphingosine kinase 1 and S1P lyase. PLoS One, 6 (1). e16571.

Pyne, Susan and Bittman, Robert and Pyne, Nigel (2011) Sphingosine kinase inhibitors and cancer : seeking the golden sword of Hercules. Cancer Research, 71 (21). pp. 6576-6582. ISSN 0008-5472

Pyne, Susan and Pyne, Nigel J (2011) Translational aspects of sphingosine 1-phosphate biology. Trends in Molecular Medicine, 17. pp. 463-472.

2010

Loveridge, Carolyn and Tonelli, Francesca and Leclercq, Tamara and Lim, Keng Gat and Long, Jaclyn S and Berdyshev, Evgeny and Tate, Rothwelle J and Natarajan, Viswanathan and Pitson, Stuart M and Pyne, Nigel J and Pyne, Susan (2010) The sphingosine kinase 1 inhibitor 2-(P-hydroxyanilino)-4-(P-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells. Journal of Biological Chemistry, 285 (50). pp. 38841-38852. ISSN 1083-351X

Long, J.S. and Fujiwara, Y. and Edwards, J. and Tannahill, C.L. and Tigyi, G. and Pyne, S. and Pyne, N.J. (2010) Sphingosine 1-phosphate receptor 4 uses HER2 (ErbB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells. Journal of Biological Chemistry, 285. pp. 35957-35966. ISSN 1083-351X

Watson, C. and Long, J.S. and Orange, C. and Tannahill, C.L. and Mallon, E. and McGlynn, L.M. and Pyne, S. and Pyne, N.J. and Edwards, J. (2010) High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. American Journal of Pathology, 177 (5). pp. 2205-2215. ISSN 0002-9440

Valentine, W.J. and Kiss, G.N. and Liu, J. and E, Shuyu and Gotoh, M. and Murakami-Murofushi, K. and Pham, T.C. and Baker, D.L. and Parrill, A.L. and Lu, X. and Sun, C. and Bittman, R. and Pyne, N.J. and Tigyi, G. (2010) (S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity. Cellular Signalling, 22 (10). pp. 1543-1553. ISSN 1873-3913

Long, J.S. and Edwards, J. and Watson, C and Tovey, S and Mair, K.M. and Schiff, R. and Natarajan, V. and Pyne, N.J. and Pyne, S. (2010) Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor-2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells. Molecular and Cellular Biology, 30 (15). pp. 3827-3841. ISSN 0270-7306

Pyne, N.J. and Pyne, S. (2010) Sphingosine 1-phosphate and cancer. Nature Reviews Cancer, 10 (7). pp. 489-503. ISSN 1474-175X

Mair, K.M. and Kane, K.A. and Pyne, S. and Pyne, N.J. and Kennedy, S. (2010) Interaction between anandamide and sphingosine 1-phosphate in mediating vasorelaxation in rat coronary artery. British Journal of Pharmacology, 161 (1). pp. 176-192. ISSN 1476-5381

Furman, Brian and Ong, Wee Kiat and Pyne, Nigel J.; Shahidul Islam, Md., ed. (2010) Cyclic AMP signalling in pancreatic islets. In: The Islets of Langerhans. Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, 654 . UNSPECIFIED, Dordrecht, Netherlands, pp. 281-304. ISBN 9789048132713

Tonelli, F. and Lim, K.G. and Loveridge, Carolyn and Long, J. and Pitson, S.M. and Tigyi, G. and Bittman, R. and Pyne, S. and Pyne, N.J. (2010) FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. Cellular Signalling, 22 (10). pp. 1536-1542. ISSN 1873-3913

McDonald, Robert A. and Pyne, S. and Pyne, N.J. and Wainwright, C.L. and Wadsworth, R.M. (2010) The sphingosine kinase inhibitor N, N-dimethylsphingosine inhibits neointimal hyperplasia. British Journal of Pharmacology, 159 (3). pp. 543-553. ISSN 1476-5381

2009

Pyne, S. and Lee, S.C. and Long, J. and Gillies, L. and Pyne, N.J. (2009) Spatial aspects of signalling by sphingosine 1-phosphate. Naunyn-Schmiedeberg's Archives of Pharmacology, 380 (4). p. 369.

Ong, W.K. and Gribble, F.M. and Reimann, F. and Lynch, M.J. and Houslay, M.D. and Baillie, G.S. and Furman, B.L. and Pyne, N.J. (2009) The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release. British Journal of Pharmacology, 157 (4). pp. 633-644. ISSN 1476-5381

Gillies, L. and Lee, S.C. and Long, J.S. and Ktistakis, N. and Pyne, N.J. and Pyne, S. (2009) The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division. Cellular Signalling, 21 (5). pp. 675-684. ISSN 1873-3913

Kennedy, S. and Kane, K.A. and Pyne, N.J. and Pyne, S. (2009) Targeting sphingosine-1-phosphate signalling for cardioprotection. Current Opinion in Pharmacology, 9 (2). pp. 194-201. ISSN 1471-4892

Pyne, S. and Lee, S.C. and Long, J.S. and Pyne, N.J. (2009) Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. Cellular Signalling, 21 (1). pp. 14-21. ISSN 1873-3913

Pyne, Nigel J. and Long, Jaclyn S. and Lee, Sue Chin and Loveridge, Carolyn and Gillies, Laura and Pyne, Susan (2009) New aspects of sphingosine 1-phosphate signaling in mammalian cells. Advances in Enzyme Regulation, 49 (1). pp. 214-221. ISSN 0065-2571

Rodgers, A. and Mormeneo, D. and Long, J.S. and Delgado, A. and Pyne, N.J. and Pyne, S. (2009) Sphingosine 1-phosphate regulation of extracellular signal regulated kinase-1/2 in embyronic stem cells. Stem Cells and Development, 18 (9). pp. 1319-1330. ISSN 1547-3287

2008

Gorshkova, Irina and He, Donghong and Berdyshev, Evgeny and Usatuyk, Peter and Burns, Michael and Kalari, Satish and Zhao, Yutang and Pendyala, Srikanth and Garcia, Joe G.N. and Pyne, N.J. and Brindley, David N. and Natarajan, Viswanathan (2008) Protein kinase C-epsilon regulates sphingosine-1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein Kinase C-zeta, and Rac1. Journal of Biological Chemistry, 283 (17). pp. 11794-11806. ISSN 1083-351X

Long, J.S. and Pyne, N.J. and Pyne, S. (2008) Lipid phosphate phosphatases form homo- and hetero-oligomers : catalytic competency, subcellular distribution and function. Biochemical Journal, 411 (2). pp. 371-377. ISSN 0264-6021

Pyne, N.J. and Pyne, S. (2008) Sphingosine 1-phosphate, lysophosphatidic acid and growth factor signaling and termination. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 1781 (9). pp. 467-476. ISSN 1388-1981

2007

Pyne, N.J. and Waters, C. and Long, J.S.L. and Akhtar Moughal, N. and Tigyi, G. and Pyne, S. (2007) Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells. Advances in Enzyme Regulation, 47 (1). pp. 271-280. ISSN 0065-2571

2006

Moughal, Noreen A and Waters, Catherine M and Valentine, William J and Connell, Michelle and Richardson, Jill C and Tigyi, Gabor and Pyne, Susan and Pyne, Nigel J (2006) Protean agonism of the lysophosphatidic acid receptor-1 with Ki16425 reduces nerve growth factor-induced neurite outgrowth in pheochromocytoma 12 cells. Journal of Neurochemistry, 98 (6). pp. 1920-1929. ISSN 0022-3042

Waters, C. and Saatian, B. and Akhtar Moughal, N. and Zhao, Y. and Tigyi, G. and Natarajan, V. and Pyne, S. and Pyne, N.J. (2006) Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells. Biochemical Journal, 398. pp. 55-62. ISSN 0264-6021

Zhao, Y. and He, D. and Saatian, B. and Watkins, T. and Spannhake, E.W. and Pyne, N.J. and Natarajan, V. (2006) Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase cdelta, lyn kinase, and matrix metalloproteinases. Journal of Biological Chemistry, 281 (28). pp. 19501-19511. ISSN 1083-351X

Long, J.S.L. and Pyne, N.J. and Pyne, S. (2006) The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells. Prostaglandins and Other Lipid Mediators, 79 (3-4). pp. 278-286. ISSN 1098-8823

Waters, C. and Long, J.S.L. and Gorshkova, I. and Fujiwara, Y. and Connell, M. and Belmonte, K.E. and Tigyi, G. and Natarajan, V. and Pyne, S. and Pyne, N.J. (2006) Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1. FASEB Journal, 20. pp. 509-511. ISSN 0892-6638

Pyne, N.J. and Long, J.S.L. and Yokoyama, K. and Tigyi, G. and Pyne, S. (2006) Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration. Biochemical Journal, 394. pp. 495-500. ISSN 0264-6021

Furman, B.L. and Pyne, N.J. (2006) Modulation of cyclic nucleotides and cyclic nucleotide phosphodiesterases in pancreatic islet beta-cells and intestinal l-cells as targets for treating diabetes mellitus. Current Opinion in Investigational Drugs, 7 (10). pp. 898-905. ISSN 1472-4472

Pyne, N.J. and Murray, Fiona and Tate, R. and MacLean, Margaret R; Beavo, J and Francis, S and Houslay, MD, eds. (2006) Molecular determinants in pulmonary hypertension : the role of PDE5. In: Cyclic Nucleotide Phosphodiesterases in Health and Diseases. CRC/Taylor & Francis Group, Boca Raton, pp. 501-518. ISBN 9780849396687

Sambi, B.S. and Hains, M. and Waters, C. and Connell, M. and Willard, F.S. and Kimple, A.J. and Pyne, S. and Siderovski, D.P. and Pyne, N.J. (2006) The effect of RGS12 on PDGFβ receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells. Cellular Signalling, 18. pp. 971-981. ISSN 1873-3913

Long, J.S.L. and Natarajan, V. and Tigyi, G. and Pyne, S. and Pyne, N.J. (2006) The functional pDGFβ receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor. Prostaglandins and Other Lipid Mediators, 80. pp. 74-80. ISSN 1098-8823

2005

Long, Jaclyn and Darroch, Peter and Wan, Kah Fei and Kong, Kok Choi and Ktistakis, Nicholas and Pyne, Nigel J and Pyne, Susan (2005) Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools. Biochemical Journal, 391 (1). pp. 25-32.

Waters, Catherine M and Connell, Michelle C and Pyne, Susan and Pyne, Nigel J (2005) c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells. Cellular Signalling, 17 (2). pp. 263-277. ISSN 1873-3913

Pyne, S and Long, J S and Ktistakis, N T and Pyne, N J (2005) Lipid phosphate phosphatases and lipid phosphate signalling. Biochemical Society Transactions, 33 (6). pp. 1370-1374. ISSN 0300-5127

2004

Furman, B and Pyne, N and Flatt, P and O'Harte, F (2004) Targeting beta-cell cyclic 3 ' 5 ' adenosine monophosphate for the development of novel drugs for treating type 2 diabetes mellitus. A review. Journal of Pharmacy and Pharmacology, 56 (12). pp. 1477-1492. ISSN 0022-3573

Waters, Catherine and Pyne, Susan and Pyne, Nigel J (2004) The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction. Seminars in Cell and Developmental Biology, 15 (3). pp. 309-323. ISSN 1084-9521

Moughal, Noreen Akhtar and Waters, Catherine and Sambi, Balwinder and Pyne, Susan and Pyne, Nigel J (2004) Nerve growth factor signaling involves interaction between the Trk A receptor and lysophosphatidate receptor 1 systems: nuclear translocation of the lysophosphatidate receptor 1 and Trk A receptors in pheochromocytoma 12 cells. Cellular Signalling, 16 (1). pp. 127-136. ISSN 1873-3913

Broderick, Kate E and Kean, Laura and Dow, Julian A T and Pyne, Nigel J and Davies, Shireen A (2004) Ectopic expression of bovine type 5 phosphodiesterase confers a renal phenotype in Drosophila. Journal of Biological Chemistry, 279 (9). pp. 8159-8168. ISSN 1083-351X

Pyne, Nigel J and Waters, Catherine and Moughal, Noreen Akhtar and Sambi, Balwinder and Connell, Michelle and Pyne, Susan (2004) Experimental systems for studying the role of G-protein-coupled receptors in receptor tyrosine kinase signal transduction. Methods in Enzmology, 390. pp. 451-475. ISSN 0076-6879

2003

Pyne, N J and Waters, C and Moughal, N A and Sambi, B S and Pyne, S (2003) Receptor tyrosine kinase-GPCR signal complexes. Biochemical Society Transactions, 31 (6). pp. 1220-1225. ISSN 0300-5127

Frame, Mhairi J and Tate, Rothwelle and Adams, David R and Morgan, Keith M and Houslay, M D and Vandenabeele, Peter and Pyne, Nigel J (2003) Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1). European Journal of Biochemistry, 270 (5). pp. 962-970. ISSN 0014-2956

Waters, C.M. and Sambi, B. and Kong, K.C. and Thompson, Dawn and Pitson, S.M. and Pyne, S. and Pyne, N.J. (2003) Sphingosine 1-phosphate and platelet-derived growth factor (pdgf) act via pdgf beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells. Journal of Biological Chemistry, 278 (8). pp. 6282-6290. ISSN 1083-351X

Pyne, N J and Furman, B L (2003) Cyclic nucleotide phosphodiesterases in pancreatic islets. Diabetologia, 46 (9). pp. 1179-1189. ISSN 0012-186X

Bruton, J.D. and Lemmens, R. and Shi, C.L. and Persson-Sjogren, H. and Westerblad, H. and Ahmed, M. and Pyne, N.J. and Frame, M.J. and Furman, B.L. and Islam, M.S. (2003) Ryanodine receptors of pancreatic beta-cells mediate a distinct context-dependent signal for insulin secretion. FASEB Journal, 17. pp. 301-303. ISSN 0892-6638

Pyne, Nigel J and MacLean, Margaret R (2003) An assessment of the role of the inhibitory gamma subunit of the retinal cyclic GMP phosphodiesterase and its effect on the p42/p44 mitogen-activated protein kinase pathway in animal and cellular models of pulmonary hypertension. British Journal of Pharmacology, 138 (7). pp. 1313-9. ISSN 1476-5381

Wan, K.F. and Sambi, B.S. and Tate, R. and Waters, C. and Pyne, N.J. (2003) The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and g-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor. Journal of Biological Chemistry, 278. pp. 18658-18663. ISSN 1083-351X

2002

Murray, Fiona and MacLean, Margaret R and Pyne, Nigel J (2002) Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension. British Journal of Pharmacology, 137 (8). pp. 1187-1194. ISSN 1476-5381

Pyne, Susan and Pyne, Nigel J (2002) Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors. BBA - Biochimica et Biophysica Acta, 1582 (1-3). pp. 121-131. ISSN 0006-3002

Zhang, L. and Parratt, J.R. and Beastall, G.H. and Pyne, N.J. and Furman, B.L. (2002) Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism. European Journal of Pharmacology, 435 (2-3). pp. 269-276. ISSN 0014-2999

Tate, R. and Arshavsky, V.Y. and Pyne, N.J. (2002) The identification of the inhibitory gamma-subunits of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase in non-retinal tissues: differential processing of mRNA transcripts. Genomics, 79 (4). pp. 582-586. ISSN 1089-8646

2001

Frame, Mhairi and Wan, Kah Fei and Tate, R. and Vandenabeele, Peter and Pyne, Nigel J. (2001) The gamma subunit of the rod photoreceptor cGMP phosphodiesterase can modulate the proteolysis of two cGMP binding cGMP-specific phosphodiesterases (PDE6 and PDE5) by caspase-3. Cellular Signalling, 13 (10). pp. 735-741. ISSN 1873-3913

Work, L.M. and McPhaden, A.R. and Pyne, N.J. and Pyne, S. and Wadsworth, R.M. and Wainwright, C.L. (2001) Short-term local delivery of an inhibitor of ras farnesyltransferase prevents neointima formation in vivo after porcine coronary balloon angioplasty. Circulation, 104 (13). pp. 1538-1543. ISSN 0009-7322

Alderton, F. and Sambi, B.S. and Tate, R. and Pyne, N.J. and Pyne, S. (2001) Assessment of agonism at g-protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells. British Journal of Pharmacology, 134 (1). pp. 6-9. ISSN 1476-5381

Alderton, Forbes and Darroch, Peter and Sambi, Balwinder and McKie, Amanda and Ahmed, Ikhlas Said and Pyne, Nigel and Pyne, Susan (2001) G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by liPID phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells. Journal of Biological Chemistry, 276. pp. 13452-13460. ISSN 1083-351X

Rakhit, S. and Pyne, S. and Pyne, N.J. (2001) Nerve growth factor stimulation of p42/p44 mitogen-activated protein kinase in PC12 cells: role of G(i/o), G protein-coupled receptor kinase 2, beta-arrestin I, and endocytic processing. Molecular Pharmacology, 60 (1). pp. 63-70. ISSN 0026-895X

Alderton, Forbes and Rakhit, Soma and Kong, Kok Choi and Palmer, Timothy and Sambi, Balwinder and Pyne, Nigel and Pyne, Susan (2001) Tethering of the platelet-derived growth factor beta receptor to g-protein-coupled receptors : a novel platform for integrative signaling by these receptor classes in mammalian cells. Journal of Biological Chemistry, 276. pp. 28578-28585. ISSN 1083-351X

Wan, K.F. and Sambi, B.S. and Frame, M.J. and Tate, R. and Pyne, N.J. (2001) The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells. Journal of Biological Chemistry, 276 (41). pp. 37794-37802. ISSN 1083-351X

2000

Conway, A M and Pyne, N J and Pyne, S (2000) Ceramide-dependent regulation of p42/p44 mitogen-activated protein kinase and c-Jun N-terminal-directed protein kinase in cultured airway smooth muscle cells. Cellular Signalling, 12 (11-12). pp. 737-743. ISSN 1873-3913

Pyne, S and Pyne, N (2000) Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors. Pharmacology and Therapeutics, 88 (2). pp. 115-131. ISSN 0163-7258

Rakhit, Soma and Pyne, Susan and Pyne, Nigel J. (2000) The platelet-derived growth factor receptor stimulation of p42/p44 mitogen-activated protein kinase in airway smooth muscle involves a G-protein-mediated tyrosine phosphorylation of Gab1. Molecular Pharmacology, 58 (2). pp. 413-420. ISSN 0026-895X

Ahmad, Masroor and Flatt, Peter R. and Furman, Brian L. and Pyne, Nigel J. (2000) The role of the cyclic GMP-inhibited cyclic AMP-specific phosphodiesterase (PDE3) in regulating clonal BRIN-BD11 insulin secreting cell survival. Cellular Signalling, 12 (8). pp. 541-548. ISSN 1873-3913

Huston, Elaine and Beard, Matthew and McCallum, Fraser and Pyne, Nigel J. and Vandenabeele, Peter and Scotland, Grant and Houslay, Miles D. (2000) The cAMP-specific phosphodiesterase PDE4A5 is cleaved downstream of its SH3 interaction domain by caspase-3 : consequences for altered intracellular distribution. Journal of Biological Chemistry, 275 (36). pp. 28063-28074. ISSN 1083-351X

Ahmad, M and Abdel-Wahab, Y H and Tate, R and Flatt, P R and Pyne, N J and Furman, B L (2000) Effect of type-selective inhibitors on cyclic nucleotide phosphodiesterase activity and insulin secretion in the clonal insulin secreting cell line BRIN-BD11. British Journal of Pharmacology, 129 (6). pp. 1228-1234. ISSN 1476-5381

1999

Pyne, S and Rakhit, S and Conway, A M and McKie, A and Darroch, P and Tate, R and Pyne, N (1999) Extracellular actions of sphingosine 1-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis. Biochemical Society Transactions, 27 (4). pp. 404-409. ISSN 0300-5127

Tolan, D and Conway, A M and Rakhit, S and Pyne, N and Pyne, S (1999) Assessment of the extracellular and intracellular actions of sphingosine 1-phosphate by using the p42/p44 mitogen-activated protein kinase cascade as a model. Cellular Signalling, 11 (5). pp. 349-354. ISSN 1873-3913

Rakhit, S and Conway, A M and Tate, R and Bower, T and Pyne, N J and Pyne, S (1999) Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinase. Biochemical journal, 338 (3). pp. 643-649. ISSN 0264-6021

Conway, A M and Rakhit, S and Pyne, S and Pyne, N J (1999) Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle : role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase. Biochemical journal, 337 (2). pp. 171-177. ISSN 0264-6021

Rakhit, Soma and Pyne, Nigel and Conway, A-M and Pyne, Susan; Thiery, Jean Paul, ed. (1999) Sphingosine 1-phosphate signalling via Edg receptors in cultured airway smooth muscle cells. In: Molecular Mechanisms of Transcellular Signaling. NATO Science Series A: Life Sciences . IOS Press, GRC, pp. 126-133. ISBN 4274902994

1998

Pyne, N J and Pyne, S (1998) PDGF-stimulated cyclic AMP formation in airway smooth muscle : assessment of the roles of MAP kinase, cytosolic phospholipase A2, and arachidonate metabolites. Cellular Signalling, 10 (5). pp. 363-369. ISSN 1873-3913

Tate, R J and Lochhead, A and Brzeski, H and Arshavsky, V and Pyne, N J (1998) The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung. Cell Biochemistry and Biophysics, 29 (1-2). pp. 133-144. ISSN 1085-9195

1997

Pyne, N J and Tolan, D and Pyne, S (1997) Bradykinin stimulates cAMP synthesis via mitogen-activated protein kinase-dependent regulation of cytosolic phospholipase A2 and prostaglandin E2 release in airway smooth muscle. Biochemical journal, 328 (2). pp. 689-694. ISSN 0264-6021

Tolan, D and Conway, A M and Pyne, N J and Pyne, S (1997) Sphingosine prevents diacylglycerol signaling to mitogen-activated protein kinase in airway smooth muscle. American Journal of Physiology, 273 (3). C928-936. ISSN 0002-9513

Lochhead, A and Nekrasova, E and Arshavsky, V Y and Pyne, N J (1997) The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase. Journal of Biological Chemistry, 272 (29). pp. 18397-18403. ISSN 1083-351X

Pyne, N J and Pyne, S (1997) Platelet-derived growth factor activates a mammalian Ste20 coupled mitogen-activated protein kinase in airway smooth muscle. Cellular Signalling, 9 (3-4). pp. 311-317. ISSN 1873-3913

Pyne, S and Tolan, D G and Conway, A M and Pyne, N (1997) Sphingolipids as differential regulators of cellular signalling processes. Biochemical Society Transactions, 25 (2). pp. 549-556. ISSN 0300-5127

El-Metwally, M and Shafiee-Nick, R and Pyne, N J and Furman, B L (1997) The effect of selective phosphodiesterase inhibitors on plasma insulin concentrations and insulin secretion in vitro in the rat. European Journal of Pharmacology, 324 (2-3). pp. 227-232. ISSN 0014-2999

Thomas, G and Burns, F and Pyne, Susan and Pyne, Nigel (1997) Characterisation of an extract from the leaves of Cissampelos sympodials Eichl. on the spontaneous tone of isolated trachea. Phytotherapy Research, 11. pp. 496-499. ISSN 1099-1573

Wilson, S. and Lugnier, C and Stoclet, J-C and Vegh, A and Pyne, Nigel and Parratt, J.R. (1997) Phosphodiesterase isozymes from the hearts of dogs subjected to cardiac pacing. Experimental and Clinical Cardiology, 2 (2). pp. 103-106.

1996

Tolan, D and Conway, A M and Steele, L and Pyne, S and Pyne, N J (1996) The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. British Journal of Pharmacology, 119 (2). pp. 185-186. ISSN 1476-5381

Piacentini, L. and Pyne, Nigel; Wainwright, C.L. and Parratt, J.R., eds. (1996) The role of G-proteins in myocardial preconditioning. In: Myocardial Preconditioning. Springer, pp. 147-166. ISBN 9783662222065

Pyne, S and Chapman, J and Steele, L and Pyne, N J (1996) Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle. European Journal of Biochemistry, 237 (3). pp. 819-826. ISSN 0014-2956

Pyne, S and Pyne, N J (1996) The differential regulation of cyclic AMP by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal regulated kinase-2 in airway smooth muscle. Biochemical journal, 315 (3). pp. 917-923. ISSN 0264-6021

Wilson, S and Song, W and Karoly, K and Ravingerova, T and Vegh, A and Papp, J and Tomisawa, S and Parratt, J R and Pyne, N J (1996) Delayed cardioprotection is associated with the sub-cellular relocalisation of ventricular protein kinase C epsilon, but not p42/44MAPK. Molecular and Cellular Biochemistry, 160-161. pp. 225-230. ISSN 0300-8177

1995

Ravingerová, T and Pyne, N J and Parratt, J R (1995) Ischaemic preconditioning in the rat heart : the role of G-proteins and adrenergic stimulation. Molecular and Cellular Biochemistry, 147 (1-2). pp. 123-128. ISSN 0300-8177

Moughal, N and Stevens, P A and Kong, D and Pyne, S and Pyne, N J (1995) Adenylate cyclase, cyclic AMP and extracellular-signal-regulated kinase-2 in airway smooth muscle - modulation by protein kinase C and growth serum. Biochemical journal, 306 (3). pp. 723-726. ISSN 0264-6021

Pyne, Nigel (1995) Cell signalling targets for novel anti-inflammatory drugs : The 19th Meeting of the British Inflammation Research Association held at the University of Strathclyde on 4-5 August, 1994. Inflammation Research, 44 (2). pp. 64-65. ISSN 1023-3830

Pyne, S and Pyne, N J (1995) Bradykinin-stimulated phosphatidylcholine hydrolysis in airway smooth muscle: the role of Ca2+ and protein kinase C. Biochemical journal, 311 (2). pp. 637-642. ISSN 0264-6021

Shafiee-Nick, R and Pyne, N J and Furman, B L (1995) Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity. British Journal of Pharmacology, 115 (8). pp. 1486-1492. ISSN 1476-5381

Nixon, G F and Pyne, N J and Wadsworth, R M and Hamilton, C A and Reid, J L (1995) Pertussis toxin sensitive endothelin-1 coupling to inositol phosphate formation via a GTP-binding protein: comparison in SHR and WKY cultured aortic smooth muscle cells. Clinical and Experimental Hypertension, 17 (3). pp. 507-22. ISSN 1064-1963

Stevens, P A and Pyne, N J (1995) The inhibition of adenylyl cyclase activity in isolated lung membranes by muscarinic and alpha-adrenoceptor agonists: role of G-protein alpha and beta gamma sub-units. Cellular Signalling, 7 (2). pp. 157-63. ISSN 1873-3913

1994

Burns, F and Stevens, P A and Pyne, N J (1994) The identification of apparently novel cyclic AMP and cyclic GMP phosphodiesterase activities in guinea-pig tracheal smooth muscle. British Journal of Pharmacology, 113 (1). pp. 3-4. ISSN 1476-5381

Pyne, Nigel and Pyne, Susan; Giembycz, M and Raeburn, D, eds. (1994) G-proteins in airway smooth muscle. In: Airways Smooth Muscle. Birkhauser Velaag, pp. 187-213. ISBN 9780817650438

Stevens, P A and Pyne, S and Grady, M and Pyne, N J (1994) Bradykinin-dependent activation of adenylate cyclase activity and cyclic AMP accumulation in tracheal smooth muscle occurs via protein kinase C-dependent and -independent pathways. Biochemical journal, 297 (1). pp. 233-9. ISSN 0264-6021

Pyne, S and Pyne, N J (1994) Bradykinin-stimulated phosphatidate and 1,2-diacylglycerol accumulation in guinea-pig airway smooth muscle: evidence for regulation 'down-stream' of phospholipases. Cellular Signalling, 6 (3). pp. 269-77. ISSN 1873-3913

Pyne, N J and Moughal, N and Stevens, P A and Tolan, D and Pyne, S (1994) Protein kinase C-dependent cyclic AMP formation in airway smooth muscle: the role of type II adenylate cyclase and the blockade of extracellular-signal-regulated kinase-2 (ERK-2) activation. Biochemical journal, 304 (2). pp. 611-616. ISSN 0264-6021

1993

Pyne, S and Pyne, N J (1993) Differential effects of B(2) receptor antagonists upon bradykinin-stimulated phospholipase C and phospholipase D in guinea-pig cultured tracheal smooth muscle. British Journal of Pharmacology, 110 (1). pp. 477-481. ISSN 1476-5381

GRADY, M and STEVENS, P A and PYNE, S and PYNE, N (1993) Adenylyl cyclase in lung from hypersensitive guinea pig displays increased responsiveness to guanine nucleotides and isoprenaline: The role of the G proteins Gs and Gi. BBA - Biochimica et Biophysica Acta, 1176 (3). pp. 313-320. ISSN 0006-3002

Pyne, S and Pyne, N J (1993) Bradykinin stimulates phospholipase D in primary cultures of guinea-pig tracheal smooth muscle. Biochemical Pharmacology, 45 (3). pp. 593-603. ISSN 0006-2952

Pyne, N J and Pyne, S (1993) Cellular signal pathways in tracheal smooth muscle. Cellular Signalling, 5 (4). pp. 401-409. ISSN 1873-3913

Pyne, Nigel and Rodger, I W; Chung, K.F. and Barnes, P.J., eds. (1993) G-proteins and receptor-mediated processes. In: Pharmacology of the Respiratory Tract. Lung Biology in Health and Disease . CRC Press, pp. 47-62. ISBN 9780824788476

Pyne, N J and Burns, F (1993) Lung phosphodiesterase isoenzymes. Agents and actions. Supplements, 43. pp. 35-49. ISSN 0379-0363

1992

Burns, F and Pyne, N J (1992) Interaction of the catalytic subunit of protein kinase A with the lung type V cyclic GMP phosphodiesterase : modulation of non-catalytic binding sites. Biochemical and Biophysical Research Communications, 189 (3). pp. 1389-1396. ISSN 1090-2104

Burns, F and Rodger, I W and Pyne, N J (1992) The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP-specific phosphodiesterase from guinea-pig lung. Biochemical journal, 283 (2). pp. 487-491. ISSN 0264-6021

Rodger, I W and Pyne, Nigel; Barnes, P.J. and Rodger, I.W. and Thomson, N.C., eds. (1992) Airway smooth muscle. In: Asthma: Basic Mechanisms and Clinical Management. Academic Press, pp. 59-84. ISBN 9780120790265

Pyne, Nigel (1992) Guanine-nucleotide binding regulatory proteins as targets for novel drugs. Proceedings - Royal Society of Edinburgh. Section B: Natural environment, 99 (1-2). pp. 27-36. ISSN 0308-2113

Pyne, N J and Grady, M W and Shehnaz, D and Stevens, P A and Pyne, S and Rodger, I W (1992) Muscarinic blockade of beta-adrenoceptor-stimulated adenylyl cyclase: the role of stimulatory and inhibitory guanine-nucleotide binding regulatory proteins (Gs and Gi). British Journal of Pharmacology, 107 (3). pp. 881-7. ISSN 1476-5381

Pyne, N J and Freissmuth, M and Pyne, S (1992) Phosphorylation of the recombinant spliced variants of the alpha-sub-unit of the stimulatory guanine-nucleotide binding regulatory protein (Gs) by the catalytic sub-unit of protein kinase A. Biochemical and Biophysical Research Communications, 186 (2). pp. 1081-1086. ISSN 1090-2104

Pyne, N J and Freissmuth, M and Palmer, S (1992) Phosphorylation of the spliced variant forms of the recombinant stimulatory guanine-nucleotide-binding regulatory protein (Gs alpha) by protein kinase C. Biochemical journal, 285 ( Pt . pp. 333-8. ISSN 0264-6021

1990

Bushfield, M and Griffiths, S L and Murphy, G J and Pyne, N J and Knowler, J T and Milligan, G and Parker, P J and Mollner, S and Houslay, M D (1990) Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein Gi-2 in hepatocytes. Biochemical journal, 271 (2). pp. 365-372. ISSN 0264-6021

Bushfield, M and Pyne, N J and Houslay, M D (1990) Changes in the phosphorylation state of the inhibitory guanine-nucleotide-binding protein Gi-2 in hepatocytes from lean (Fa/Fa) and obese (fa/fa) Zucker rats. European Journal of Biochemistry, 192 (2). pp. 537-542. ISSN 0014-2956

Lakey, T and Pyne, Nigel and Murphy, G J; Hutton, J.C. and Siddle, K., eds. (1990) Cyclic nucleotides. In: Peptide Hormone Analysis. IRL Press, Oxford, pp. 73-113. ISBN 9780199630714

Houslay, M.D. and Bushfield, M and Kilgour, E and Lavan, B E and Griffiths, S and Pyne, Nigel and Tang, I and Murphy, G; Konijn, T.M. and Houslay, M.D. and van Haastert, P.J.M., eds. (1990) Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase. In: Activation and Desensitisation of Transducing Pathways. NATO ASI series, 44 . Springer-Verlag, pp. 63-83. ISBN 9783642836183