Sphingosine 1-phosphate and cancer

Pyne, N.J. and Pyne, S. (2010) Sphingosine 1-phosphate and cancer. Nature Reviews Cancer, 10 (7). pp. 489-503. ISSN 1474-175X

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Official URL: https://doi.org/10.1038/nrc2875

Abstract

There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer. S1P regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival. This occurs at multiple levels and involves S1P receptors, sphingosine kinases, S1P phosphatases and S1P lyase. This Review summarizes current research findings and examines the potential for new therapeutics designed to alter S1P signalling and function in cancer.

Author(s):	Pyne, N.J. ORCID: https://orcid.org/0000-0002-5657-4578 and Pyne, S. ORCID: https://orcid.org/0000-0002-6608-9584
Item type:	Article
ID code:	28084
Keywords:	sphingosine 1-phosphate, cancer, neovascularization, inflammation, Immunology, Therapeutics. Pharmacology, Neoplasms. Tumors. Oncology (including Cancer), Cancer Research, Oncology
Subjects:	Science > Microbiology > Immunology Medicine > Therapeutics. Pharmacology Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer)
Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user:	Miss Shauna Thompson
Date deposited:	13 Oct 2010 11:32
Last modified:	24 Jan 2020 06:13
URI:	https://strathprints.strath.ac.uk/id/eprint/28084
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