Sphingosine 1-phosphate and cancer
Pyne, N.J. and Pyne, S. (2010) Sphingosine 1-phosphate and cancer. Nature Reviews Cancer, 10 (7). pp. 489-503. ISSN 1474-175X
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Abstract
There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer. S1P regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival. This occurs at multiple levels and involves S1P receptors, sphingosine kinases, S1P phosphatases and S1P lyase. This Review summarizes current research findings and examines the potential for new therapeutics designed to alter S1P signalling and function in cancer.
Creators(s): |
Pyne, N.J. ![]() ![]() | Item type: | Article |
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ID code: | 28084 |
Keywords: | sphingosine 1-phosphate, cancer, neovascularization, inflammation, Immunology, Therapeutics. Pharmacology, Neoplasms. Tumors. Oncology (including Cancer), Cancer Research, Oncology |
Subjects: | Science > Microbiology > Immunology Medicine > Therapeutics. Pharmacology Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer) |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
Depositing user: | Miss Shauna Thompson |
Date deposited: | 13 Oct 2010 11:32 |
Last modified: | 29 Jan 2021 03:52 |
URI: | https://strathprints.strath.ac.uk/id/eprint/28084 |
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