Sphingosine 1-phosphate and cancer
Pyne, N.J. and Pyne, S. (2010) Sphingosine 1-phosphate and cancer. Nature Reviews Cancer, 10 (7). pp. 489-503. ISSN 1474-175X
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Abstract
There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer. S1P regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival. This occurs at multiple levels and involves S1P receptors, sphingosine kinases, S1P phosphatases and S1P lyase. This Review summarizes current research findings and examines the potential for new therapeutics designed to alter S1P signalling and function in cancer.
ORCID iDs
Pyne, N.J.
ORCID: https://orcid.org/0000-0002-5657-4578 and Pyne, S. ORCID: https://orcid.org/0000-0002-6608-9584;
Item type: Article ID code: 28084 Dates: DateEventJuly 2010PublishedKeywords: sphingosine 1-phosphate, cancer, neovascularization, inflammation, Immunology, Therapeutics. Pharmacology, Neoplasms. Tumors. Oncology (including Cancer), Cancer Research, Oncology Subjects: Science > Microbiology > Immunology
Medicine > Therapeutics. Pharmacology
Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer)Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Miss Shauna Thompson Date deposited: 13 Oct 2010 11:32 Last modified: 16 Apr 2021 02:25 URI: https://strathprints.strath.ac.uk/id/eprint/28084
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)