Sphingosine 1-phosphate and cancer

Pyne, N.J. and Pyne, S. (2010) Sphingosine 1-phosphate and cancer. Nature Reviews Cancer, 10 (7). pp. 489-503. ISSN 1474-175X (https://doi.org/10.1038/nrc2875)

Abstract

There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer. S1P regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival. This occurs at multiple levels and involves S1P receptors, sphingosine kinases, S1P phosphatases and S1P lyase. This Review summarizes current research findings and examines the potential for new therapeutics designed to alter S1P signalling and function in cancer.

ORCID iDs

Pyne, N.J. ORCID: https://orcid.org/0000-0002-5657-4578

Pyne, S. ORCID: https://orcid.org/0000-0002-6608-9584

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  Item type:	Article
  ID code:	28084
  Dates:	Date Event July 2010 Published
  Keywords:	sphingosine 1-phosphate, cancer, neovascularization, inflammation, Immunology, Therapeutics. Pharmacology, Neoplasms. Tumors. Oncology (including Cancer), Cancer Research, Oncology, SDG 3 - Good Health and Well-being
  Subjects:	Science > Microbiology > Immunology Medicine > Therapeutics. Pharmacology Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer)
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Miss Shauna Thompson
  Date deposited:	13 Oct 2010 11:32
  Last modified:	02 Dec 2023 02:46
  URI:	https://strathprints.strath.ac.uk/id/eprint/28084