Does insulin exert certain of its actions through a distinct species of guanine nucleotide regulatory protein?

Houslay, M D and Wallace, A V and Cooper, M E and Pyne, Nigel and Wilson, S R and Heyworth, C M (1984) Does insulin exert certain of its actions through a distinct species of guanine nucleotide regulatory protein? Biochemical Society Transactions, 12 (5). pp. 766-8. ISSN 0300-5127 (https://doi.org/10.1042/bst0120766)

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Abstract

One of the central features of insulin’s action on the liver is its ability to antagonize the actions of glucagon. Glucagon switches on glycogenolysis and gluconeogenesis in the liver by raising intracellular cyclic A M P concentrations through stimulating the activity of adenylate cyclase. Insulin would appear to achieve its antagonistic effect by causing a decrease in the intracellular concentrations of cyclic A M P .

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