Cyclic AMP signalling in pancreatic islets

Furman, Brian and Ong, Wee Kiat and Pyne, Nigel J.; Shahidul Islam, Md., ed. (2010) Cyclic AMP signalling in pancreatic islets. In: The Islets of Langerhans. Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, 654 . UNSPECIFIED, Dordrecht, Netherlands, pp. 281-304. ISBN 9789048132713 (

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Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in intracellular calcium concentrations, and by the incretin hormones (GLP-1 and GIP). cAMP is rapidly degraded in the pancreatic islet β-cell by various cyclic nucleotide phosphodiesterase (PDE) enzymes. Many steps involved in glucose-induced insulin secretion are modulated by cAMP, which is also important in regulating pancreatic islet β-cell differentiation, growth and survival. This chapter discusses the formation, destruction and actions of cAMP in the islets with particular emphasis on the β-cell.