Cyclic AMP signalling in pancreatic islets
Furman, Brian and Ong, Wee Kiat and Pyne, Nigel J.; Shahidul Islam, Md., ed. (2010) Cyclic AMP signalling in pancreatic islets. In: The Islets of Langerhans. Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, 654 . UNSPECIFIED, Dordrecht, Netherlands, pp. 281-304. ISBN 9789048132713 (https://doi.org/10.1007/978-90-481-3271-3_13)
PDF.
Filename: AdvexpmedFinal_proof_chapter_13_2_.pdf
Accepted Author Manuscript Download (337kB) |
Abstract
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in intracellular calcium concentrations, and by the incretin hormones (GLP-1 and GIP). cAMP is rapidly degraded in the pancreatic islet β-cell by various cyclic nucleotide phosphodiesterase (PDE) enzymes. Many steps involved in glucose-induced insulin secretion are modulated by cAMP, which is also important in regulating pancreatic islet β-cell differentiation, growth and survival. This chapter discusses the formation, destruction and actions of cAMP in the islets with particular emphasis on the β-cell.
ORCID iDs
Furman, Brian, Ong, Wee Kiat and Pyne, Nigel J. ORCID: https://orcid.org/0000-0002-5657-4578; Shahidul Islam, Md.-
-
Item type: Book Section ID code: 25943 Dates: DateEvent15 January 2010PublishedSubjects: Science > Chemistry
Medicine > Therapeutics. PharmacologyDepartment: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Strathprints Administrator Date deposited: 24 Aug 2010 11:24 Last modified: 28 Sep 2024 00:34 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/25943