Sphingosine kinases : emerging structure function insights
Adams, David R. and Pyne, Susan and Pyne, Nigel J. (2016) Sphingosine kinases : emerging structure function insights. Trends in Biochemical Sciences, 41 (5). pp. 395-409. ISSN 0968-0004 (https://doi.org/10.1016/j.tibs.2016.02.007)
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Abstract
Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structural and functional characterisation of SK1 and these are contextualised by analysis of crystal structures for closely related prokaryotic lipid kinases. We identify a putative dimerisation interface and propose novel regulatory mechanisms governing structural plasticity induced by phosphorylation and interaction with phospholipids and proteins. Our analysis suggests that the catalytic function and regulation of the enzymes might be dependent on conformational mobility and it provides a roadmap for future interrogation of SK1 function and its role in physiology and disease.
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Item type: Article ID code: 55993 Dates: DateEvent1 May 2016Published25 March 2016Published Online17 February 2016AcceptedSubjects: Medicine > Pharmacy and materia medica
Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer)Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 23 Mar 2016 16:57 Last modified: 28 Jul 2024 22:46 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/55993