Sphingosine 1-phosphate receptor 1 signaling in mammalian cells

Pyne, Nigel J. and Pyne, Susan (2017) Sphingosine 1-phosphate receptor 1 signaling in mammalian cells. Molecules, 22 (3). pp. 1-18. 344. ISSN 1420-3049

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    Abstract

    The bioactive lipid, sphingosine 1-phosphate (S1P) binds to a family of G protein-coupled receptors, termed S1P1-S1P5. These receptors function in, for example, the cardiovascular system to regulate vascular barrier integrity and tone, the nervous system to regulate neuronal differentiation, myelination and oligodendrocyte/glial cell survival and the immune system to regulate T- and B-cell subsets and trafficking. S1P receptors also participate in the pathophysiology of autoimmunity, inflammatory disease, cancer, neurodegeneration and others. In this review, we describe how S1P1 can form a complex with G-protein and β-arrestin, which function together to regulate effector pathways. We also discuss the role of the S1P1-Platelet derived growth factor receptor β functional complex (which deploys G-protein/β-arrestin and receptor tyrosine kinase signaling) in regulating cell migration. Possible mechanisms by which different S1P-chaperones, such as Apolipoprotein M-High-Density Lipoprotein induce biological programmes in cells are also described. Finally, the role of S1P1 in health and disease and as a target for clinical intervention is appraised.

    Author(s):Pyne, Nigel J. ORCID logoORCID: https://orcid.org/0000-0002-5657-4578 and Pyne, Susan ORCID logoORCID: https://orcid.org/0000-0002-6608-9584
    Item type:Article
    ID code:59942
    Keywords:sphingosine 1-phosphate, G-protein coupled receptor, megaplex, receptor tyrosine kinase, immune trafficking, neovascularisation, cardiovascular;, cancer, Therapeutics. Pharmacology, Pharmacology, Toxicology and Pharmaceutics(all)
    Subjects:Medicine > Therapeutics. Pharmacology
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:23 Feb 2017 15:04
    Last modified:22 Nov 2019 05:40
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/59942
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