Sphingosine 1-phosphate receptor 1 signaling in mammalian cells
Pyne, Nigel J. and Pyne, Susan (2017) Sphingosine 1-phosphate receptor 1 signaling in mammalian cells. Molecules, 22 (3). pp. 1-18. 344. ISSN 1420-3049
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Abstract
The bioactive lipid, sphingosine 1-phosphate (S1P) binds to a family of G protein-coupled receptors, termed S1P1-S1P5. These receptors function in, for example, the cardiovascular system to regulate vascular barrier integrity and tone, the nervous system to regulate neuronal differentiation, myelination and oligodendrocyte/glial cell survival and the immune system to regulate T- and B-cell subsets and trafficking. S1P receptors also participate in the pathophysiology of autoimmunity, inflammatory disease, cancer, neurodegeneration and others. In this review, we describe how S1P1 can form a complex with G-protein and β-arrestin, which function together to regulate effector pathways. We also discuss the role of the S1P1-Platelet derived growth factor receptor β functional complex (which deploys G-protein/β-arrestin and receptor tyrosine kinase signaling) in regulating cell migration. Possible mechanisms by which different S1P-chaperones, such as Apolipoprotein M-High-Density Lipoprotein induce biological programmes in cells are also described. Finally, the role of S1P1 in health and disease and as a target for clinical intervention is appraised.
Creators(s): |
Pyne, Nigel J. ![]() ![]() | Item type: | Article |
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ID code: | 59942 |
Keywords: | sphingosine 1-phosphate, G-protein coupled receptor, megaplex, receptor tyrosine kinase, immune trafficking, neovascularisation, cardiovascular;, cancer, Therapeutics. Pharmacology, Pharmacology, Toxicology and Pharmaceutics(all) |
Subjects: | Medicine > Therapeutics. Pharmacology |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
Depositing user: | Pure Administrator |
Date deposited: | 23 Feb 2017 15:04 |
Last modified: | 05 Mar 2021 04:15 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/59942 |
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