New perspectives on the role of sphingosine 1-phosphate in cancer

Pyne, Susan and Pyne, Nigel; Gulbins, Erich and Petrache, Irina, eds. (2013) New perspectives on the role of sphingosine 1-phosphate in cancer. In: Sphingolipids in Disease. Handbook of experimental pharmacology . Springer-Verlag, Vienna, pp. 55-71. ISBN 9783709115107

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Abstract

In this chapter, we review the latest developments concerning the role of sphingosine 1-phosphate (S1P) in cancer. Particular focus is paid to the role of sphingosine kinases 1 and 2, S1P lyase and S1P-dependent signalling networks in both solid tumours and haematological cancer. The potential of this S1P-dependent pathophysiology as a therapeutic target for the treatment of cancer is also discussed.