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2024

Wiejak, Jolanta and Murphy, Fiona A. and Barker, Graeme and Maffia, Pasquale and Yarwood, Stephen J. (2024) Non-cyclic nucleotide EPAC1 activators suppress lipopolysaccharide-regulated gene expression, signalling and intracellular communication in differentiated macrophage-like THP-1 cells. Cellular Signalling, 124. 111444. ISSN 1873-3913

2023

McIntosh, Kathryn and Khalaf, Yousif H. and Craig, Rachel and West, Christopher and McCulloch, Ashley and Waghmare, Ajay and Lawson, Christopher and Chan, Edmond Y.W. and MacKay, Simon and Paul, Andrew and Plevin, Robin (2023) IL-1β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling. Cellular Signalling, 107. 110684. ISSN 1873-3913

2021

Schwalm, Stephanie and Beyer, Sandra and Hafizi, Redona and Traufmann, Sandra and Geisslinger, Gerd and Adams, David R. and Pyne, Susan and Pyne, Nigel and Schaefer, Liliana and Huwiler, Andrea and Pfeilschifter, Josef (2021) Validation of highly selective Sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis. Cellular Signalling, 79. 109881. ISSN 1873-3913

2020

Adams, David R. and Pyne, Susan and Pyne, Nigel J. (2020) Structure-function analysis of lipid substrates and inhibitors of sphingosine kinases. Cellular Signalling, 76. 109806. ISSN 1873-3913

2018

Ng, Pei Y. and McIntosh, Kathryn A. and Hargrave, Gillian and Ho, Ka H. and Paul, Andrew and Plevin, Robin (2018) Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells. Cellular Signalling, 51. pp. 59-71. ISSN 1873-3913

Martin, Tamara P. and McCluskey, Claire and Cunningham, Margaret R. and Beattie, James and Paul, Andrew and Currie, Susan (2018) CaMKIIδ interacts directly with IKKβ and modulates NF-kB signalling in adult cardiac fibroblasts. Cellular Signalling. ISSN 1873-3913

Shukla, Arun K. and Pyne, Nigel J. (2018) Cellular Signalling – Special issue to celebrate 75th birthday of Prof. Robert J. Lefkowitz. Cellular Signalling, 41. p. 1. ISSN 1873-3913

2016

MacRitchie, Neil and Volpert, Giora and Al Washih, Mohammed and Watson, David G. and Futerman, Anthony H. and Kennedy, Simon and Pyne, Susan and Pyne, Nigel J. (2016) Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodeling in a hypoxic model of pulmonary arterial hypertension. Cellular Signalling, 28 (8). pp. 946-955. ISSN 1873-3913

2015

Bolger, Graeme B. and Dunlop, Allan J. and Meng, Dong and Day, Jon P. and Klussmann, Enno and Baillie, George S. and Adams, David R. and Houslay, Miles D. (2015) Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains. Cellular Signalling, 27 (4). pp. 756-769. ISSN 1873-3913

2014

Ohotski, Jan and Rosen, Hugh and Bittman, Robert and Pyne, Susan and Pyne, Nigel J (2014) Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth : the role of sphingosine 1-phosphate receptor-4. Cellular Signalling, 26 (5). pp. 1040-1047. ISSN 1873-3913

2013

Watson, David G and Tonelli, Francesca and Al Osaimi, Manal and Williamson, Leon and Chan, Edmond and Gorshkova, Irina and Berdyshev, Evgeny and Bittman, Robert and Pyne, Nigel J and Pyne, Susan (2013) The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. Cellular Signalling, 25 (4). pp. 1011-1017. ISSN 1873-3913

Mleczak, Andrzej and Millar, Sarah and Tooze, Sharon A and Olson, Michael F and Chan, Edmond Y W (2013) Regulation of autophagosome formation by Rho kinase. Cellular Signalling, 25 (1). pp. 1-11. ISSN 1873-3913

2011

Lim, Keng Gat and Sun, Chaode and Bittman, Robert and Pyne, Nigel J and Pyne, Susan (2011) (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor : Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. Cellular Signalling, 23 (10). pp. 1590-1595. ISSN 1873-3913

2010

Valentine, W.J. and Kiss, G.N. and Liu, J. and E, Shuyu and Gotoh, M. and Murakami-Murofushi, K. and Pham, T.C. and Baker, D.L. and Parrill, A.L. and Lu, X. and Sun, C. and Bittman, R. and Pyne, N.J. and Tigyi, G. (2010) (S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity. Cellular Signalling, 22 (10). pp. 1543-1553. ISSN 1873-3913

McIntosh, K. and Cunningham, M.R. and Cadalbert, L. and Lochart, J. and Boyd, G. and Ferrell, W.R. and Plevin, R.J. (2010) Proteinase-activated receptor-2 mediated inhibition of TNFα-stimulated JNK activation — A novel paradigm for Gq/11 linked GPCRs. Cellular Signalling, 22 (2). pp. 265-273. ISSN 1873-3913

Tonelli, F. and Lim, K.G. and Loveridge, Carolyn and Long, J. and Pitson, S.M. and Tigyi, G. and Bittman, R. and Pyne, S. and Pyne, N.J. (2010) FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. Cellular Signalling, 22 (10). pp. 1536-1542. ISSN 1873-3913

2009

Gillies, L. and Lee, S.C. and Long, J.S. and Ktistakis, N. and Pyne, N.J. and Pyne, S. (2009) The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division. Cellular Signalling, 21 (5). pp. 675-684. ISSN 1873-3913

Cadalbert, C. and Sloss, C.M. and Cunningham, M.M. and Al-Muteiri, M. and McIntire, A. and Shipley, J. and Plevin, R. (2009) Differential regulation of MAP kinase activation by a novel splice variant of human MAP kinase phosphatase-2. Cellular Signalling, 22 (3). pp. 357-365. ISSN 1873-3913

Pyne, S. and Lee, S.C. and Long, J.S. and Pyne, N.J. (2009) Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. Cellular Signalling, 21 (1). pp. 14-21. ISSN 1873-3913

2008

Goh, F.G. and Sloss, C.M. and Cunningham, M.R. and Nilsson, M. and Cadalbert, Laurence and Plevin, R.J. (2008) G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 nf kappa b serine 536 phosphorylation in human keratinocytes. Cellular Signalling, 20 (7). pp. 1267-1274. ISSN 1873-3913

2007

MacKenzie, C. and Ritchie, E. and Paul, A. and Plevin, R.J. (2007) IKKalpha and IKKbeta function in TNFalpha-stimulated adhesion molecule expression in human aortic smooth muscle cells. Cellular Signalling, 19. pp. 75-80. ISSN 1873-3913

2006

Sambi, B.S. and Hains, M. and Waters, C. and Connell, M. and Willard, F.S. and Kimple, A.J. and Pyne, S. and Siderovski, D.P. and Pyne, N.J. (2006) The effect of RGS12 on PDGFβ receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells. Cellular Signalling, 18. pp. 971-981. ISSN 1873-3913

2005

Waters, Catherine M and Connell, Michelle C and Pyne, Susan and Pyne, Nigel J (2005) c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells. Cellular Signalling, 17 (2). pp. 263-277. ISSN 1873-3913

2004

Moughal, Noreen Akhtar and Waters, Catherine and Sambi, Balwinder and Pyne, Susan and Pyne, Nigel J (2004) Nerve growth factor signaling involves interaction between the Trk A receptor and lysophosphatidate receptor 1 systems: nuclear translocation of the lysophosphatidate receptor 1 and Trk A receptors in pheochromocytoma 12 cells. Cellular Signalling, 16 (1). pp. 127-136. ISSN 1873-3913

Seatter, Michael J and Drummond, Robert and Kanke, Toru and Macfarlane, Scott R and Hollenberg, Morley D and Plevin, Robin (2004) The role of the C-terminal tail in protease-activated receptor-2-mediated Ca2+ signalling, proline-rich tyrosine kinase-2 activation, and mitogen-activated protein kinase activity. Cellular Signalling, 16 (1). pp. 21-29. ISSN 1873-3913

2001

Frame, Mhairi and Wan, Kah Fei and Tate, R. and Vandenabeele, Peter and Pyne, Nigel J. (2001) The gamma subunit of the rod photoreceptor cGMP phosphodiesterase can modulate the proteolysis of two cGMP binding cGMP-specific phosphodiesterases (PDE6 and PDE5) by caspase-3. Cellular Signalling, 13 (10). pp. 735-741. ISSN 1873-3913

Robinson, C. and Sloss, C.M. and Plevin, R.J. (2001) Inactivation of jNK ACtivity by mitogen-activated protein kinase phosphatase-2 in Eahy926 endothelial cells is dependent upon agonist-specific jNK translocation to the nucleus. Cellular Signalling, 13 (1). pp. 29-41. ISSN 1873-3913

2000

Conway, A M and Pyne, N J and Pyne, S (2000) Ceramide-dependent regulation of p42/p44 mitogen-activated protein kinase and c-Jun N-terminal-directed protein kinase in cultured airway smooth muscle cells. Cellular Signalling, 12 (11-12). pp. 737-743. ISSN 1873-3913

Ahmad, Masroor and Flatt, Peter R. and Furman, Brian L. and Pyne, Nigel J. (2000) The role of the cyclic GMP-inhibited cyclic AMP-specific phosphodiesterase (PDE3) in regulating clonal BRIN-BD11 insulin secreting cell survival. Cellular Signalling, 12 (8). pp. 541-548. ISSN 1873-3913

1999

Tolan, D and Conway, A M and Rakhit, S and Pyne, N and Pyne, S (1999) Assessment of the extracellular and intracellular actions of sphingosine 1-phosphate by using the p42/p44 mitogen-activated protein kinase cascade as a model. Cellular Signalling, 11 (5). pp. 349-354. ISSN 1873-3913

Tate, R J and Tolan, D and Pyne, S (1999) Molecular cloning of magnesium-independent type 2 phosphatidic acid phosphatases from airway smooth muscle. Cellular Signalling, 11 (7). pp. 515-522. ISSN 1873-3913

1998

Pyne, N J and Pyne, S (1998) PDGF-stimulated cyclic AMP formation in airway smooth muscle : assessment of the roles of MAP kinase, cytosolic phospholipase A2, and arachidonate metabolites. Cellular Signalling, 10 (5). pp. 363-369. ISSN 1873-3913

1997

Pyne, N J and Pyne, S (1997) Platelet-derived growth factor activates a mammalian Ste20 coupled mitogen-activated protein kinase in airway smooth muscle. Cellular Signalling, 9 (3-4). pp. 311-317. ISSN 1873-3913

1995

Stevens, P A and Pyne, N J (1995) The inhibition of adenylyl cyclase activity in isolated lung membranes by muscarinic and alpha-adrenoceptor agonists: role of G-protein alpha and beta gamma sub-units. Cellular Signalling, 7 (2). pp. 157-63. ISSN 1873-3913

1994

Pyne, S and Pyne, N J (1994) Bradykinin-stimulated phosphatidate and 1,2-diacylglycerol accumulation in guinea-pig airway smooth muscle: evidence for regulation 'down-stream' of phospholipases. Cellular Signalling, 6 (3). pp. 269-77. ISSN 1873-3913

1993

Pyne, N J and Pyne, S (1993) Cellular signal pathways in tracheal smooth muscle. Cellular Signalling, 5 (4). pp. 401-409. ISSN 1873-3913

1989

Palmer, S and Hughes, K T and Lee, D Y and Wakelam, M J (1989) Development of a novel, Ins(1,4,5)P3-specific binding assay. Its use to determine the intracellular concentration of Ins(1,4,5)P3 in unstimulated and vasopressin-stimulated rat hepatocytes. Cellular Signalling, 1 (2). pp. 147-56. ISSN 1873-3913