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2024

Geiser, Angéline and Currie, Susan and Al-Hasani, Hadi and Chadt, Alexandra and McConnell, Gail and Gould, Gwyn W. (2024) A novel 3D imaging approach for quantification of GLUT4 levels across the intact myocardium. Journal of Cell Science, 137 (20). jcs262146. ISSN 0021-9533

Olatunji, Zainab and Currie, Susan and MacQuaide, Niall (2024) CaMKII augments ROS and Ca2+ entry processes in female cardiac fibroblasts in hyperglycemic and hypertensive conditions. Heart, 110 (Suppl ). ISSN 1468-201X

Olatunji, Zainab and Currie, Susan and MacQuaide, Niall (2024) The role of CaMKII in the structural and functional remodelling of cardiac myocytes in heart failure with preserved ejection fraction. European Heart Journal. ISSN 0195-668X (In Press)

Jenkinson, Mark R. J. and Meek, Dominic R. M. and Tate, Rothwelle and Brady, Adrian and MacMillan, Sandy and Grant, Helen and Currie, Susan (2024) Cardiac function may be compromised in patients with elevated blood cobalt levels secondary to metal-on-metal hip implants : a pilot study using a novel echocardiography measurement. The Bone & Joint Journal, 106-B (No.3 S). pp. 51-58. ISSN 2049-4394

2023

Olatunji, Zainab O. and Currie, Susan and Macquaide, Niall (2023) Calcium signalling in cardiac fibroblasts and myocytes in an in vitro model of HFpEF. In: Physiological Society - cross talk of cells in the heart, 2023-09-11 - 2023-09-12, University of Liverpool.

Olatunji, Zainab O. and Bosakhar, Zainab and MacKenzie, Graeme and Cunningham, Margaret and Macquaide, Niall and Currie, Susan (2023) Altered regulation of cardiac calcium handling proteins in an in vivo rat model of angiotensin-induced hypertension. In: British Society for Cardiovascular research Autumn meeting 2023, 2023-09-04 - 2023-09-05, University of Oxford.

Jenkinson, Mark and Meek, Dominic and MacMillan, Sandy and Tate, Rothwelle and Grant, Mary and Currie, Susan (2023) Cardiac function is compromised in patients with elevated blood cobalt levels secondary to metal-on-metal hip implants. Heart, 109 (Supple). A4. ISSN 1468-201X

Olatunji, Zainab O and MacMillan, Sandy and Cameron-Ruiz, Miren and Bosakhar, Zainab Y and MacKenzie, Graeme and Grant, Mary H and Tate, Rothwelle and MacQuaide, Niall and Currie, Susan (2023) Effects of acute and chronic cobalt treatment on adult rat cardiomyocyte calcium handling. Heart, 109 (Supple). A6. ISSN 1468-201X

2022

Jenkinson, M. R.J. and Meek, R.M.D. and MacMillan, S. and Tate, R. and Grant, M.H. and Currie, S. (2022) Global longitudinal strain is compromised in patients with elevated blood cobalt levels secondary to metal-on-metal hip implants. In: Europhysiology 2022, 2022-09-16 - 2022-09-18, Tivoli Conference Centre.

Wu, Junxi and Zhu, Dongxing and Currie, Susan (2022) Editorial: Arteriogenesis and collateral remodelling in ischaemic disease. Frontiers in Cardiovascular Medicine, 9. 916218. ISSN 2297-055X

2021

Longhorn, Daniel and McCormick, Christopher and Currie, Susan (2021) Characterising endothelial CaMKII oxidation in a cellular model of inflammation to investigate the therapeutic potential of a novel anti-oxidant stent coating. In: 36th Annual Meeting of the International Society for Heart Research European Section International Society of Heart Research, 2021-06-29 - 2021-07-01, virtual.

Jenkinson, Mark R. J. and Meek, Dominic R. M. and Tate, Rothwelle and MacMillan, Sandy and Grant, M. Helen and Currie, Susan (2021) Cobalt-induced cardiomyopathy - do circulating cobalt levels matter? Bone and Joint Research, 10 (6). 340–347. ISSN 2046-3758

McMullen, Calum J. and Chalmers, Susan and Wood, Rachel and Cunningham, Margaret R. and Currie, Susan (2021) Sunitinib and imatinib display differential cardiotoxicity in adult rat cardiac fibroblasts that involves a role for calcium/calmodulin dependent protein kinase II. Frontiers in Cardiovascular Medicine, 7. 630480. ISSN 2297-055X

2020

Veerman, Ben and McGivern, Samantha-Joe and Dempsie, Yvonne and Martin, Patricia E M and Johnston, Blair and Currie, Susan and Cunningham, Margaret Rose (2020) Dysregulation of endothelial cell connexin-43 localisation in response to doxorubicin. Heart, 106 (1). 11. ISSN 1468-201X

Longhorn, Daniel and Currie, Susan and McCormick, Christopher (2020) Parallel development and characterisation of an anti-oxidant stent coating and an in vitro biological model for qualitative assessment. Heart, 106 (Suppl ). ISSN 1468-201X

McMullen, CJ and Chalmers, S and Cunningham, MR and Currie, S (2020) Sunitinib mediates mitochondrial ROS production in adult rat cardiac fibroblasts via CaMKII oxidation. Heart, 106 (Suppl ). OP8. ISSN 1468-201X

2019

McCluskey, Claire and Mooney, Laura and Paul, Andrew and Currie, Susan (2019) Compromised cardiovascular function in aged rats corresponds with increased expression and activity of calcium/calmodulin dependent protein kinase IIδ in aortic endothelium. Vascular pharmacology, 118-119. 106560. ISSN 1879-3649

McMullen, Calum J and Wood, Rachel A and Cunningham, Margaret R and Currie, Susan (2019) Assessment of adult rat cardiac fibroblast viability following chronic sunitinib treatment. Heart, 105 (suppl ). A6-A7. ISSN 1468-201X

2018

Laovitthayanggoon, Sarunya and Henderson, Catherine J. and McCluskey, Claire and Macdonald, Margaret and Tate, Rothwelle J. and Grant, M. Helen and Currie, Susan (2018) Cobalt administration causes reduced contractility with parallel increases in TRPC6 and TRPM7 transporter protein expression in adult rat hearts. Cardiovascular Toxicology. ISSN 1559-0259

Martin, Tamara P. and McCluskey, Claire and Cunningham, Margaret R. and Beattie, James and Paul, Andrew and Currie, Susan (2018) CaMKIIδ interacts directly with IKKβ and modulates NF-kB signalling in adult cardiac fibroblasts. Cellular Signalling. ISSN 1873-3913

McMullen, CJ and McCluskey, C and Kim, SJ and Laovitthayanggoon, S and MacDonald, M and Safar, M and Wood, R and Cunningham, MR and Currie, S (2018) Anti-cancer tyrosine kinase inhibitors increase oxidative stress in primary cardiac fibroblasts. Heart, 104 (S4). ISSN 1468-201X

McBride, Domenica and ALHAZMI, Abdulfattah Yahya M and Laovitthayanggoon, Sarunya and Boyd, Marie and Currie, Susan (2018) Parallel assessment of cell viability in cardiac and cancer cells following treatment with sunitinib. Heart, 104 (S4). 6. ISSN 1468-201X

2017

Ewart, Marie-ann and Ugusman, Azizah and Vishwanath, Anisha and Almabrouk, Tarek A.M. and Alganga, Husman and Katwan, Omar J. and Hubanova, Pavlina and Currie, Susan and Kennedy, Simon (2017) Changes in IP3 receptor expression and function in aortic smooth muscle of atherosclerotic mice. Journal of Vascular Research, 54 (2). ISSN 1018-1172

Gomez Arnaiz, Sara and Tate, Rothwelle and Currie, Susan and Grant, Mary (2017) In vitro effects of cobalt ions on CNS derived cell lines. In: British Toxicology Society Congress 2017, 2017-04-03 - 2017-04-05, Hilton Hotel.

Laovitthayanggoon, Sarunya and Henderson, Catherine J. and Tate, Rothwelle J. and Currie, Susan and McCluskey, Claire and Macdonald, Margaret and Grant, M. Helen (2017) In vivo and in vitro toxicity of cobalt in the heart. In: British Toxicology Society Congress 2017, 2017-04-03 - 2017-04-05, Hilton Hotel.

McCluskey, Claire and Macdonald, Margaret and Currie, Susan (2017) Ageing of the vascular endothelium : a novel role for CaMKIIδ. Heart, 103 (S2). A2. 3. ISSN 1468-201X

Laovitthayanggoon, Sarunya and Grant, M. Helen and Henderson, Catherine J. and Tate, Rothwelle J. and Currie, Susan (2017) CoCl2 induced cardiotoxicity associated with CoCr alloy orthopaedic implants. Heart, 103 (S2). A4. 9. ISSN 1468-201X

Huq, Molly and Currie, Susan and Coats, Paul (2017) The effect of hypoxic mediated pro-mitogenic signalling pro-mitogenic signalling associated with vein graft failure and vascular remodelling. Heart, 103 (S2). A7. 15. ISSN 1468-201X

2016

Laovitthayanggoon, Sarunya and Grant, M. Helen and Henderson, Catherine J. and Tate, Rothwelle J. and Currie, Susan (2016) Investigating cobalt toxicity in the context of joint replacement patients - cobalt uptake in primary cardiac fibroblasts and in 3T3 cells. Applied in Vitro Toxicology, 2 (4). ISSN 2332-1539

Currie, Susan and Qim, Kimberley and Mum, Hui and Campbell, Sara and MacKenzie, Graeme and Mohd Salleh, Mohd Hanif and Chellapan, Dinesh and Candasamy, Mayuren (2016) Effects of trans-isoferulic acid and gallic acid on cardiac contractility : is there a role for CaMKII? International Journal of Molecular Medicine, 38 (S1). 149. ISSN 1791-244X

McCluskey, Claire and Salleh, Hanif and Currie, Susan (2016) Calcium/calmodulin-dependent protein kinase II - does ageing mirror disease? FASEB Journal, 30 (1 supp). 767.3. ISSN 0892-6638

Laovitthayanggoon, Sarunya and Tate, Rothwelle and Currie, Susan and Grant, Mary Helen (2016) Cobalt cardiotoxicity - effects on the contractile and non-contractile cells of the heart. FASEB Journal, 30 (1). 178.7. ISSN 0892-6638

Currie, Susan and Martin, Tamara Patricia and Salleh, Hanif and McCluskey, Claire and Bushell, Trevor John (2016) Inositol trisphosphate receptor contribution to ventricular cardiac fibroblast function in healthy and hypertrophied mouse hearts. FASEB Journal, 30 (1 Supp). 1178.2. ISSN 0892-6638

2015

MacAskill, Mark G. and Watson, David G. and Ewart, Marie-Ann and Wadsworth, Roger and Jackson, Andrew and Aitken, Emma and MacKenzie, Graeme and Kingsmore, David and Currie, Susan and Coats, Paul (2015) Improving arteriovenous fistula patency : transdermal delivery of diclofenac reduces cannulation-dependent neointimal hyperplasia via AMPK activation. Vascular pharmacology, 71. pp. 108-115. ISSN 1879-3649

McCluskey, Claire and Paul, Andrew and Currie, Susan (2015) Pro-inflammatory signalling in vascular endothelium: a novel role for CaMKIIdelta in ageing. Heart, 101 (S4). A100-A101. ISSN 1468-201X

Sin, Yuan Yan and Martin, Tamara P and Wills, Lauren and Currie, Susan and Baillie, George S (2015) Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy. Cell Communication and Signalling, 13. 16.

Mooney, L and Skinner, M and Coker, S. J. and Currie, S. (2015) Effect of acute and chronic sunitinib treatment on cardiac function and CaMKII. British Journal of Pharmacology. ISSN 1476-5381

2014

Mohd Salleh, M and McCluskey, C and Bushell, T and Currie, S (2014) Calcium/calmodulin dependent protein kinase II δ modulates intracellular CA2+ release and cell proliferation in adult cardiac fibroblasts. Heart, 100 (S4). ISSN 1468-201X

Huq, M and Currie, S and Coats, P (2014) Hypoxia mediated signalling in vein graft remodelling and failure. Heart, 100 (S4). ISSN 1468-201X

Ewart, Marie-ann and Kennedy, Simon and MacMillan, Debbi and Watt, Ian and Currie, Susan (2014) Altered vascular smooth muscle cell function in the ApoE knock-out mouse during the progression of atherosclerosis. Atherosclerosis, 234 (1). pp. 154-161. ISSN 0021-9150

Martin, Tamara and Currie, Susan and Baillie, George (2014) The cardioprotective role of small heat shock protein 20. Biochemical Society Transactions, 42 (2). pp. 270-273. ISSN 0300-5127

Martin, Tamara P. and Lawan, Ahmed and Robinson, Emma and Grieve, David J. and Plevin, Robin and Paul, Andrew and Currie, Susan (2014) Adult cardiac fibroblast proliferation is modulated by calcium/calmodulin-dependent protein kinase II in normal and hypertrophied hearts. Pflugers Archiv - European Journal of Physiology, 466 (2). 319–330. ISSN 0031-6768

Martin, Tamara and Hortigon-Vinagre, Maria and Findlay, Jane and Elliott, Christina and Currie, Susan and Baillie, George (2014) Targeted disruption of the heat shock protein 20–phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy. FEBS Open Bio, 4. pp. 923-927. ISSN 2211-5463

2013

Martin, Tamara Patricia and Norris, Greg and McConnell, Gail and Currie, Susan (2013) A novel approach for assessing cardiac fibrosis using label-free second harmonic generation. International Journal of Cardiovascular Imaging.

2012

Martin, Tamara P and Robinson, Emma and Harvey, Adam P and Macdonald, Margaret and Grieve, David J and Paul, Andrew and Currie, Susan (2012) Surgical optimization and characterization of a minimally invasive aortic banding procedure to induce cardiac hypertrophy in mice. Experimental Physiology, 97 (7). pp. 822-832.

Mooney, Laura and Marks, Louise and Philp, Karen L and Skinner, Matthew and Coker, Susan J and Currie, Susan (2012) Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs. Journal of Pharmacological and Toxicological Methods, 66 (1). pp. 43-51.

Marshall, Gillian E and Russell, Julie A and Tellez, James O and Jhund, Pardeep S and Currie, Susan and Dempster, John and Boyett, Mark R and Kane, Kathleen A and Rankin, Andrew C and Workman, Antony J (2012) Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade. Pflugers Archiv - European Journal of Physiology, 463 (4). pp. 537-548. ISSN 0031-6768

2011

Lawan, Ahmed and Al-Harthi, Sameer and Cadalbert, Laurence and McCluskey, Anthony G. and Shweash, Muhannad and Grassia, Gianluca and Grant, Anne and Boyd, Marie and Currie, Susan and Plevin, Robin (2011) Deletion of the dual specific phosphatase-4 (DUSP-4) gene reveals an essential non-redundant role for MAP kinase phosphatase-2 (MKP-2) in proliferation and cell survival. Journal of Biological Chemistry, 286 (15). pp. 12933-12943. ISSN 1083-351X

Currie, Susan and Elliott, Elspeth B and Smith, Godfrey L and Loughrey, Christopher M (2011) Two candidates at the heart of dysfunction : the ryanodine receptor and calcium/calmodulin protein kinase II as potential targets for therapeutic intervention-An in vivo perspective. Alimentary Pharmacology and Therapeutics, 131 (2). pp. 204-20.

2009

Currie, S. (2009) Cardiac ryanodine receptor phosphorylation by CaM Kinase II : Keeping the balance right. Frontiers in Bioscience, 14. pp. 5134-5156. ISSN 1093-9946

McCarron, J.G. and Olson, M. and Currie, S. and Wright, A. and Anderson, K.I. and Girkin, J.M. (2009) Elevations of intracellular calcium reflect normal voltage-dependent behavior, and not constitutive activity, of voltage-dependent calcium channels in gastrointestinal and vascular smooth muscle. Journal of General Physiology, 133 (4). pp. 439-457. ISSN 0022-1295

2008

Currie, S. and Rainbow, R. and Ewart, M-A. and Kitson, S. and Pliego, E.H. and Kane, K.A. and McCarron, J.G. (2008) IP3R-mediated Ca2+ release is modulated by anandamide in isolated cardiac nuclei. Journal of Molecular and Cellular Cardiology, 45 (6). pp. 804-811. ISSN 0022-2828

MacMillan, D. and Currie, S. and McCarron, J.G. (2008) FK506-binding protein (FKBP12) regulates ryanodine receptor-evoked Ca2+ release in colonic but not aortic smooth muscle. Cell Calcium, 43 (6). pp. 539-549. ISSN 0143-4160

2007

Currie, S. and Anthony, D.F. and Beattie, J. and Paul, A. (2007) Interaction of calcium/calmodulin-dependent protein kinase IIδC with sorcin indirectly modulates ryanodine receptor function in cardiac myocytes. Journal of Molecular and Cellular Cardiology, 43 (4). pp. 492-503. ISSN 0022-2828

2006

Smith, G.L. and Elliot, E.E.B. and Kettlewell, S. and Currie, S. and Quinn, F.R. (2006) Na+/Ca2+ exchanger expression and function in a rabbit model of myocardial infarction. Journal of Cardiovascular Electrophysiology, 17 (1). S57-S63. ISSN 1045-3873

2005

MacMillan, D. and Currie, S. and Bradley, K.N. and Muir, T.C. and McCarron, J.G. (2005) In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin. Journal of Cell Science, 118 (23). pp. 5443-5451. ISSN 0021-9533

Currie, S. and Quinn, F.R. and Sayeed, R.A. and Duncan, A.M. and Kettlewell, S. and Smith, G.L. (2005) Selective down-regulation of sub-endocardial ryanodine receptor expression in a rabbit model of left ventricular dysfunction. Journal of Molecular and Cellular Cardiology, 39 (2). pp. 309-317. ISSN 0022-2828

Miller, S.L.W. and Currie, S. and Loughrey, C.M. and Kettlewell, S. and Seidler, T. and Reynolds, D.F. and Hasenfuss, G. and Smith, G.L. (2005) Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Cardiovascular Research, 67. pp. 667-677. ISSN 0008-6363

Kettlewell, S. and Most, P. and Currie, S. and Koch, W.J. and Smith, G.L. (2005) S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes. Journal of Molecular and Cellular Cardiology, 39 (6). pp. 900-910. ISSN 0022-2828

2004

Currie, Susan and Loughrey, Christopher M and Craig, Margaret-Anne and Smith, Godfrey L (2004) Calcium/calmodulin-dependent protein kinase IIdelta associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochemical Journal, 377 (2). pp. 357-366.

Teucher, N. and Prestle, J. and Seidler, T. and Currie, S. and Elliott, E.B. and Reynolds, D.F. and Schott, P. and Wagner, S. and Kogler, H. and Inesi, G. and Bers, D.M. and Hasenfuss, G. and Smith, G.L. (2004) Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening. Circulation, 110. pp. 3553-3559. ISSN 0009-7322

2003

Quinn, F R and Currie, S and Duncan, A M and Miller, S and Sayeed, R and Cobbe, S M and Smith, G L (2003) Myocardial infarction causes increased expression but decreased activity of the myocardial Na+-Ca2+ exchanger in the rabbit. Journal of Physiology, 553 (1). pp. 229-242. ISSN 0022-3751

Bradley, K.N. and Currie, S. and MacMillan, D. and Muir, T.C. and McCarron, J.G. (2003) Cyclic ADP-ribose increases Ca2+ removal in smooth muscle. Journal of Cell Science, 116. pp. 4291-306. ISSN 0021-9533

2002

Wisløff, Ulrik and Loennechen, Jan P and Currie, Susan and Smith, Godfrey L and Ellingsen, Øyvind (2002) Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction. Cardiovascular Research, 54 (1). pp. 162-174. ISSN 0008-6363

2001

Wisløff, U and Loennechen, J P and Falck, G and Beisvag, V and Currie, S and Smith, G.L. and Ellingsen, O (2001) Increased contractility and calcium sensitivity in cardiac myocytes isolated from endurance trained rats. Cardiovascular Research, 50 (3). pp. 495-508. ISSN 0008-6363

1999

Currie, S and Smith, G L (1999) Calcium/calmodulin-dependent protein kinase II activity is increased in sarcoplasmic reticulum from coronary artery ligated rabbit hearts. FEBS Letters, 459 (2). pp. 244-248. ISSN 0014-5793

Currie, S and Smith, G L (1999) Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure. Cardiovascular Research, 41 (1). pp. 135-146. ISSN 0008-6363

1994

Currie, S and Roberts, E F and Spaethe, S M and Roehm, N W and Kramer, R M (1994) Phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in MCII mast cells mediated by high-affinity Fc receptor for IgE. Biochemical Journal, 304 (3). pp. 923-928. ISSN 0264-6021

1993

Wakelam, M J and Pettitt, T R and Kaur, P and Briscoe, C P and Stewart, A and Paul, A and Paterson, A and Cross, M J and Gardner, S D and Currie, S (1993) Phosphatidylcholine hydrolysis : a multiple messenger generating system. Advances in Second Messenger and Phosphoprotein Research, 28. pp. 73-80. ISSN 1040-7952

1992

Currie, S and Smith, G L and Crichton, C A and Jackson, C G and Hallam, C and Wakelam, M J (1992) Bombesin stimulates the rapid activation of phospholipase A2-catalyzed phosphatidylcholine hydrolysis in Swiss 3T3 cells. Journal of Biological Chemistry, 267 (9). pp. 6056-6062. ISSN 1083-351X

1991

Wakelam, M.J. and Cook, S.J. and Currie, Susan and Palmer, S. and Plevin, Robin (1991) Regulation of the hydrolysis of phosphatidylcholine in Swiss 3T3 cells. Biochemical Society Transactions, 19 (2). pp. 321-324. ISSN 0300-5127