Dysregulation of endothelial cell connexin-43 localisation in response to doxorubicin
Veerman, Ben and McGivern, Samantha-Joe and Dempsie, Yvonne and Martin, Patricia E M and Johnston, Blair and Currie, Susan and Cunningham, Margaret Rose (2020) Dysregulation of endothelial cell connexin-43 localisation in response to doxorubicin. Heart, 106 (1). 11. ISSN 1468-201X (https://doi.org/10.1136/heartjnl-2020-SCF.11)
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Abstract
Introduction: Anthracyclines, such as doxorubicin, remain an important class of chemotherapeutic agent however their efficacy in treating cancer is limited by a cumulative dose-dependent cardiotoxicity. Whilst most studies have focused on cardiomyocyte impairment, circulating doxorubicin has been shown to impact human microvascular responses to doxorubicin in coronary vessels.1 Studies show increased endothelial cell permeability resulting in increased paracellular permeability due to damage to the integrity of cell-cell junctions.2 Strategies to maintain vessel integrity and prevent endothelial cell dysregulation could represent a novel therapeutic opportunity to limit the toxic effects of doxorubicin. The aim of this project was to assess the impact of doxorubicin upon endothelial gap junction proteins, in particular connexin-43 (Cx43).
ORCID iDs
Veerman, Ben, McGivern, Samantha-Joe, Dempsie, Yvonne, Martin, Patricia E M, Johnston, Blair ORCID: https://orcid.org/0000-0001-9785-6822, Currie, Susan ORCID: https://orcid.org/0000-0002-4237-4428 and Cunningham, Margaret Rose ORCID: https://orcid.org/0000-0001-6454-8671;-
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Item type: Article ID code: 72554 Dates: DateEvent5 April 2020Published1 February 2020AcceptedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 03 Jun 2020 16:07 Last modified: 27 Sep 2024 01:17 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/72554