Altered regulation of cardiac calcium handling proteins in an in vivo rat model of angiotensin-induced hypertension

Olatunji, Zainab O. and Bosakhar, Zainab and MacKenzie, Graeme and Cunningham, Margaret and Macquaide, Niall and Currie, Susan (2023) Altered regulation of cardiac calcium handling proteins in an in vivo rat model of angiotensin-induced hypertension. In: British Society for Cardiovascular research Autumn meeting 2023, 2023-09-04 - 2023-09-05, University of Oxford.

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Abstract

Hypertension is a major comorbidity in patients with heart failure with preserved ejection fraction (HFpEF), which remains an increasing global challenge. Cardiac remodelling and dysfunction as well as altered calcium (Ca2+) homeostasis are all characteristics of this disease1,2. However, existing models and evidence on the mechanisms driving this form of cardiomyopathy remain contradictory.

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