Effect of acute and chronic sunitinib treatment on cardiac function and CaMKII

Mooney, L and Skinner, M and Coker, S. J. and Currie, S. (2015) Effect of acute and chronic sunitinib treatment on cardiac function and CaMKII. British Journal of Pharmacology. ISSN 1476-5381

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    Abstract

    Calcium/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is an important regulator of cardiac contractile function and dysfunction and may be an unwanted secondary target for anti-cancer drugs such as sunitinib and imatinib that have been reported to alter cardiac performance. This study aimed to determine whether anti-cancer kinase inhibitors may affect CaMKII activity and expression when administered in vivo.