Effect of acute and chronic sunitinib treatment on cardiac function and CaMKII

Mooney, L and Skinner, M and Coker, S. J. and Currie, S. (2015) Effect of acute and chronic sunitinib treatment on cardiac function and CaMKII. British Journal of Pharmacology. ISSN 1476-5381 (https://doi.org/10.1111/bph.13213)

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Abstract

Calcium/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is an important regulator of cardiac contractile function and dysfunction and may be an unwanted secondary target for anti-cancer drugs such as sunitinib and imatinib that have been reported to alter cardiac performance. This study aimed to determine whether anti-cancer kinase inhibitors may affect CaMKII activity and expression when administered in vivo.

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• Item metadata

  Item type:	Article
  ID code:	53456
  Dates:	Date Event 2015 Published 4 June 2015 Published Online 3 June 2015 Accepted
  Subjects:	Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Pure Administrator
  Date deposited:	22 Jun 2015 14:44
  Last modified:	11 Apr 2024 00:55
  URI:	https://strathprints.strath.ac.uk/id/eprint/53456