Assessment of adult rat cardiac fibroblast viability following chronic sunitinib treatment

McMullen, Calum J and Wood, Rachel A and Cunningham, Margaret R and Currie, Susan (2019) Assessment of adult rat cardiac fibroblast viability following chronic sunitinib treatment. Heart, 105 (suppl ). A6-A7. ISSN 1468-201X

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    Abstract

    The tyrosine kinase inhibitor sunitinib has dramatically improved cancer therapy in recent years however, this success has been marred by reports of associated cardiotoxicity. The effect of sunitinib on cardiac myocyte function has been extensively studied, yet little is known of wider ranging effects on cardiac non-myocytes. Cardiac fibroblasts (CF) are the most abundant cell type within the heart and are responsible for maintaining cardiac structure via extracellular matrix remodelling and for facilitating synchronised cardiac contraction. Here, we have investigated whether chronic sunitinib treatment adversely affects CF viability.