Calcium signalling in cardiac fibroblasts and myocytes in an in vitro model of HFpEF

Olatunji, Zainab O. and Currie, Susan and Macquaide, Niall (2023) Calcium signalling in cardiac fibroblasts and myocytes in an in vitro model of HFpEF. In: Physiological Society - cross talk of cells in the heart, 2023-09-11 - 2023-09-12, University of Liverpool.

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Abstract

Heart Failure with preserved Ejection Fraction [HFpEF] is a pandemic associated with hypertension and diabetes amongst other co-morbidities1. It has been established that fibrosis plays a major role in this form of heart failure2. However, the functional mechanisms of cardiac fibroblasts (CFs) in HFpEF and more importantly, how these cells interact with cardiomyocytes (CMs) and impact calcium (Ca2+) signalling is limited. This limitations majorly due to a lack of physiologically relevant cellular models.

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