Effects of trans-isoferulic acid and gallic acid on cardiac contractility : is there a role for CaMKII?

Currie, Susan and Qim, Kimberley and Mum, Hui and Campbell, Sara and MacKenzie, Graeme and Mohd Salleh, Mohd Hanif and Chellapan, Dinesh and Candasamy, Mayuren (2016) Effects of trans-isoferulic acid and gallic acid on cardiac contractility : is there a role for CaMKII? International Journal of Molecular Medicine, 38 (S1). ISSN 1791-244X

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Abstract

The cardioprotective effects of polyphenols appear promising: however, their mechanism of action in cardiomycytes remains unknown. CaMKII is an important intracellular modulator of normal cardiac contractility and, when overly activated, can promote contractile dysfunction. This study investigates whether trans-isoferulic acid (TIA) and gallic acid (GA) can alter CaMKII activity in cardiac tissue.