The role of sphingosine 1-phosphate in inflammation and cancer

Pyne, Nigel J and Ohotski, Jan and Bittman, Robert and Pyne, Susan (2014) The role of sphingosine 1-phosphate in inflammation and cancer. Advances in Biological Regulation, 54. pp. 121-129. ISSN 2212-4934

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    Abstract

    The enzymes that catalyze formation of the bioactive sphingolipid, sphingosine 1-phosphate, sphingosine kinase 1 and 2, are predictive markers in inflammatory diseases and cancer as evidenced by data from patients, knockout mice and the use of available molecular and chemical inhibitors. Thus, there is a compelling case for therapeutic targeting of sphingosine kinase. In addition, there are several examples of functional interaction between sphingosine 1-phosphate receptors and sphingosine kinase 1 that can drive malicious amplification loops that promote cancer cell growth. These novel aspects of sphingosine 1-phosphate pathobiology are reviewed herein.

    ORCID iDs

    Pyne, Nigel J ORCID logoORCID: https://orcid.org/0000-0002-5657-4578, Ohotski, Jan, Bittman, Robert and Pyne, Susan ORCID logoORCID: https://orcid.org/0000-0002-6608-9584;