Selectivity and specificity of sphingosine 1-phosphate receptor ligands : "off-targets" or complex pharmacology?

Pyne, Nigel J. and Pyne, Susan (2011) Selectivity and specificity of sphingosine 1-phosphate receptor ligands : "off-targets" or complex pharmacology? Frontiers in Pharmacology, 2. 26.

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    Abstract

    A recent perspective published in Frontiers of Pharmacology by Salomone and Waeber (2011) discussed the selectivity and specificity of sphingosine 1-phosphate (S1P) receptor ligands. This perspective surveyed the use of various S1P receptor ligands and attempted to reconcile a number of inconsistencies in the predicted biological outcomes: these were interpreted as "off-target" effects. Therefore the perspective cautioned against the use of these S1P receptor ligands. Here we highlight the complex pharmacology of S1P receptors, which along with "inside-out" signaling might provide an alternative explanation for "off-target" effects.

    Author(s):Pyne, Nigel J. ORCID logoORCID: https://orcid.org/0000-0002-5657-4578 and Pyne, Susan ORCID logoORCID: https://orcid.org/0000-0002-6608-9584
    Item type:Article
    ID code:32346
    Keywords:sphingosine 1-phosphate, S1P, receptor ligands, pharmacology , biological outcomes, signalling, Therapeutics. Pharmacology, Pharmacology (medical), Pharmacology
    Subjects:Medicine > Therapeutics. Pharmacology
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:28 Jul 2011 15:41
    Last modified:26 Jan 2020 23:26
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/32346
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