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Dales, Markie O. and Drummond, Robert M. and Kennedy, Charles (2024) How selective antagonists and genetic modification have helped characterise the expression and functions of vascular P2Y receptors. Purinergic Signalling. ISSN 1573-9538
2022
Dales, Markie O. and Mitchell, Callum and Gurney, Alison M. and Drummond, Robert M. and Kennedy, Charles (2022) Characterisation of P2Y receptor subtypes mediating vasodilation and vasoconstriction of rat pulmonary artery using selective antagonists. Purinergic Signalling, 18 (4). pp. 515-528. ISSN 1573-9538
2021
Kennedy, Charles (2021) ATP as a cotransmitter in sympathetic and parasympathetic nerves - another Burnstock legacy. Autonomic Neuroscience: Basic and Clinical, 235. 102860. ISSN 1566-0702
Alexander, Stephen PH and Christopoulos, Arthur and Davenport, Anthony P and Kelly, Eamonn and Mathie, Alistair and Peters, John A and Veale, Emma L and Armstrong, Jane F and Faccenda, Elena and Harding, Simon D and Pawson, Adam J and Southan, Christopher and Davies, Jamie A and Abbracchio, Maria Pia and Alexander, Wayne and Al‐hosaini, Khaled and Bäck, Magnus and Barnes, Nicholas M. and Bathgate, Ross and Beaulieu, Jean‐Martin and Bernstein, Kenneth E. and Bettler, Bernhard and Birdsall, Nigel J.M. and Blaho, Victoria and Boulay, Francois and Bousquet, Corinne and Bräuner‐Osborne, Hans and Burnstock, Geoffrey and Caló, Girolamo and Castaño, Justo P. and Catt, Kevin J. and Ceruti, Stefania and Chazot, Paul and Chiang, Nan and Chini, Bice and Chun, Jerold and Cianciulli, Antonia and Civelli, Olivier and Clapp, Lucie H. and Couture, Réjean and Csaba, Zsolt and Dahlgren, Claes and Dent, Gordon and Singh, Khuraijam Dhanachandra and Douglas, Steven D. and Dournaud, Pascal and Eguchi, Satoru and Escher, Emanuel and Filardo, Edward J. and Fong, Tung and Fumagalli, Marta and Gainetdinov, Raul R and Gasparo, Marc de and Gerard, Craig and Gershengorn, Marvin and Gobeil, Fernand and Goodfriend, Theodore L. and Goudet, Cyril and Gregory, Karen J. and Gundlach, Andrew L. and Hamann, Jörg and Hanson, Julien and Hauger, Richard L. and Hay, Debbie L. and Heinemann, Akos and Hollenberg, Morley D. and Holliday, Nicholas D. and Horiuchi, Mastgugu and Hoyer, Daniel and Hunyady, László and Husain, Ahsan and IJzerman, Adriaan P. and Inagami, Tadashi and Jacobson, Kenneth A. and Jensen, Robert T. and Jockers, Ralf and Jonnalagadda, Deepa and Karnik, Sadashiva and Kaupmann, Klemens and Kemp, Jacqueline and Kennedy, Charles and Kihara, Yasuyuki and Kitazawa, Takio and Kozielewicz, Pawel and Kreienkamp, Hans‐Jürgen and Kukkonen, Jyrki P. and Langenhan, Tobias and Leach, Katie and Lecca, Davide and Lee, John D. and Leeman, Susan E. and Leprince, Jérôme and Li, Xaria X. and Williams, Tom Lloyd and Lolait, Stephen J. and Lupp, Amelie and Macrae, Robyn and Maguire, Janet and Mazella, Jean and McArdle, Craig A. and Melmed, Shlomo and Michel, Martin C. and Miller, Laurence J. and Mitolo, Vincenzo and Mouillac, Bernard and Müller, Christa E. and Murphy, Philip and Nahon, Jean‐Louis and Ngo, Tony and Norel, Xavier and Nyimanu, Duuamene and O’Carroll, Anne‐Marie and Offermanns, Stefan and Panaro, Maria Antonietta and Parmentier, Marc and Pertwee, Roger G. and Pin, Jean‐Philippe and Prossnitz, Eric R. and Quinn, Mark and Ramachandran, Rithwik and Ray, Manisha and Reinscheid, Rainer K. and Rondard, Philippe and Rovati, G. Enrico and Ruzza, Chiara and Sanger, Gareth J. and Schöneberg, Torsten and Schulte, Gunnar and Schulz, Stefan and Segaloff, Deborah L. and Serhan, Charles N. and Stoddart, Leigh A. and Sugimoto, Yukihiko and Summers, Roger and Tan, Valerie P. and Thal, David and Thomas, Walter (Wally) and Timmermans, Pieter B. M. W. M. and Tirupula, Kalyan and Tulipano, Giovanni and Unal, Hamiyet and Unger, Thomas and Valant, Celine and Vanderheyden, Patrick and Vaudry, David and Vaudry, Hubert and Vilardaga, Jean‐Pierre and Walker, Christopher S. and Wang, Ji Ming and Ward, Donald T. and Wester, Hans‐Jürgen and Willars, Gary B and Woodruff, Trent M. and Yao, Chengcan and Ye, Richard D. (2021) The concise guide to pharmacology 2021/22 : G protein‐coupled receptors. British Journal of Pharmacology, 178 (S1). S27-S156. ISSN 1476-5381
Alexander, Stephen PH and Mathie, Alistair and Peters, John A and Veale, Emma L and Striessnig, Jörg and Kelly, Eamonn and Armstrong, Jane F and Faccenda, Elena and Harding, Simon D and Pawson, Adam J and Southan, Christopher and Davies, Jamie A and Aldrich, Richard W. and Attali, Bernard and Baggetta, Austin M and Becirovic, Elvir and Biel, Martin and Bill, Roslyn M. and Catterall, William A. and Conner, Alex C. and Davies, Paul and Delling, Markus and Virgilio, Francesco Di and Falzoni, Simonetta and Fenske, Stefanie and George, Chandy and Goldstein, Steve A. N. and Grissmer, Stephan and Ha, Kotdaji and Hammelmann, Verena and Hanukoglu, Israel and Jarvis, Mike and Jensen, Anders A. and Kaczmarek, Leonard K. and Kellenberger, Stephan and Kennedy, Charles and King, Brian and Kitchen, Philip and Lynch, Joseph W. and Perez‐Reyes, Edward and Plant, Leigh D. and Rash, Lachlan and Ren, Dejian and Salman, Mootaz M. and Sivilotti, Lucia G. and Smart, Trevor G. and Snutch, Terrance P. and Tian, Jinbin and Trimmer, James S. and Van den Eynde, Charlotte and Vriens, Joris and Wei, Aguan D. and Winn, Brenda T. and Wulff, Heike and Xu, Haoxing and Yue, Lixia and Zhang, Xiaoli and Zhu, Michael (2021) The concise guide to pharmacology 2021/22 : ion channels. British Journal of Pharmacology, 178 (S1). S157-S245. ISSN 1476-5381
Traserra, Sara and Barber, Claudia and MacInnes, Jane and Relea, Lucia and MacPherson, Lewis C. and Cunningham, Margaret R. and Vergara, Patri and Accarino, Anna and Kennedy, Charles and Jimenez, Marcel (2021) Different responses of the blockade of the P2Y1 receptor with BPTU in human and porcine intestinal tissues and in cell cultures. Neurogastroenterology and Motility, 33 (7). e14101. ISSN 1350-1925
Kennedy, Charles (2021) The P2Y/P2X divide : how it began. Biochemical Pharmacology, 187. 114408. ISSN 0006-2952
Kennedy, Charles (2021) That was then, this is now : the development of our knowledge and understanding of P2 receptor subtypes. Purinergic Signalling, 17. pp. 9-23. ISSN 1573-9538
Illes, Peter and Müller, Christa E. and Jacobson, Kenneth A. and Grutter, Thomas and Nicke, Annette and Fountain, Samuel J. and Kennedy, Charles and Schmalzing, Günther and Jarvis, Michael F. and Stojilkovic, Stanko S. and King, Brian F. and Di Virgilio, Francesco (2021) Update of P2X receptor properties and their pharmacology : IUPHAR review 30. British Journal of Pharmacology, 178 (3). pp. 489-514. ISSN 1476-5381
2020
Jacobson, Kenneth A. and Delicado, Esmerilda G. and Gachet, Christian and Kennedy, Charles and von Kügelgen, Ivar and Li, Beibei and Miras-Portugal, M. Teresa and Novak, Ivana and Schöneberg, Torsten and Perez-Sen, Raquel and Thor, Doreen and Wu, Beili and Yang, Zhenlin and Müller, Christa E. (2020) Update of P2Y receptor pharmacology : IUPHAR Review 27. British Journal of Pharmacology, 177 (11). 2413–2433. ISSN 1476-5381
2019
Muoboghare, Markie O. and Drummond, Robert M. and Kennedy, Charles (2019) Characterisation of P2Y2 receptors in human vascular endothelial cells using AR-C118925XX, a competitive and selective P2Y2 antagonist. British Journal of Pharmacology, 176 (16). pp. 2894-2904. ISSN 1476-5381
Safar, M.A. and Wood, R. and Cunningham, M.R. and Kennedy, C. (2019) P2Y1 and P2Y12 receptor heterodimerisation : from recombinant systems to native detection. British Journal of Pharmacology, 176 (16). p. 3049. ISSN 1476-5381
2018
Lee, Matthew D. and Wilson, Calum and Saunter, Christopher D. and Kennedy, Charles and Girkin, John M. and McCarron, John G. (2018) Spatially-structured cell populations process multiple sensory signals in parallel in intact vascular endothelium : stimulus-specific sensory cells in the intact vascular endothelium. Science Signaling, 11 (561). eaar4411. ISSN 1945-0877
Tengah, Ampuan and Syed, Nawazish-i-Husain and Abdul Talip, Siti Tajidah and Bujang, Siti Nur Basirah and Kennedy, Charles (2018) Comparison of signalling mechanisms underlying UTP-evoked vasoconstriction of rat pulmonary and tail arteries. European Journal of Pharmacology, 837. pp. 45-52. ISSN 0014-2999
2017
Kennedy, Charles (2017) P2Y11 receptors : properties, distribution and functions. Advances in Experimental Medicine and Biology. ISSN 0065-2598 (In Press)
2015
Kennedy, Charles (2015) ATP as a cotransmitter in the autonomic nervous system. Autonomic Neuroscience: Basic and Clinical, 191. pp. 2-15. ISSN 1566-0702
2014
Morrow, Gael B. and Nicholas, Robert A. and Kennedy, Charles (2014) UTP is not a biased agonist at human P2Y11 receptors. Purinergic Signalling, 10 (4). pp. 581-585. ISSN 1573-9538
2013
Alexander, Stephen P H and Benson, Helen E and Faccenda, Elena and Pawson, Adam J and Sharman, Joanna L and McGrath, John C and Catterall, William A and Spedding, Michael and Peters, John A and Harmar, Anthony J and Abul-Hasn, N and Anderson, C M and Anderson, C M H and Araiksinen, M S and Arita, M and Arthofer, E and Barker, E L and Barratt, C and Barnes, N M and Bathgate, R and Beart, P M and Belelli, D and Bennett, A J and Birdsall, N J M and Boison, D and Bonner, T I and Brailsford, L and Bröer, S and Brown, P and Calo, G and Carter, W G and Catterall, W A and Chan, S L F and Chao, M V and Chiang, N and Christopoulos, A and Chun, J J and Cidlowski, J and Clapham, D E and Cockcroft, S and Connor, M A and Cox, H M and Cuthbert, A and Dautzenberg, F M and Davenport, A P and Dawson, P A and Jones, R L and Kennedy, C and Pyne, N J and Pyne, S, CGTP Collaborators (2013) The Concise Guide to PHARMACOLOGY 2013/14 : overview. British Journal of Pharmacology, 170 (8). pp. 1449-58. ISSN 1476-5381
Kennedy, Charles and Chootip, Krongkarn and Mitchell, Callum and Syed, Nawazish-I-Husain and Tengah, Asrin (2013) P2X and P2Y nucleotide receptors as targets in cardiovascular disease. Future Medicinal Chemistry, 5 (4). pp. 431-439. ISSN 1756-8919
Kennedy, Charles (2013) The importance of drug discovery for treatment of cardiovascular diseases. Future Medicinal Chemistry, 5 (4). pp. 355-357. ISSN 1756-8919
2012
Mitchell, Callum and Syed, Nawazish-I-Husain and Tengah, Asrin and Gurney, Alison and Kennedy, Charles (2012) Identification of contractile P2Y1, P2Y6 and P2Y12 receptors in rat intrapulmonary artery using selective ligands. Journal of Pharmacology and Experimental Therapeutics, 343 (3). pp. 755-762. ISSN 0022-3565
MacMillan, Debbi and Kennedy, Charles and McCarron, John (2012) ATP inhibits Ins(1,4,5)P3-evoked Ca2+ release in smooth muscle via P2Y1 receptors. Journal of Cell Science, 125 (21). pp. 5151-5158. ISSN 0021-9533
Mitchell, Callum and Syed, Nawazish-I-Husain and Gurney, Alison and Kennedy, Charles (2012) A Ca2+-dependent chloride current and Ca2+ influx via Cav1.2 ion channels play major roles in P2Y receptor-mediated pulmonary vasoconstriction. British Journal of Pharmacology, 166 (4). pp. 1503-1512. ISSN 1476-5381
2010
Syed, Nawazish-I-Husain and Tengah, Asrin and Paul, Andrew and Kennedy, Charles (2010) Characterisation of P2X receptors expressed in rat pulmonary arteries. European Journal of Pharmacology, 649 (1-3). pp. 342-348. ISSN 0014-2999
Shakya-Shrestha, S. and Parmar, M. and Kennedy, Charles and Bushell, T. (2010) Two-pore potassium ion channels are inhibited by both Gq/11- and Gi-coupled P2Y receptors. Molecular and Cellular Neuroscience, 43 (4). pp. 363-369. ISSN 1044-7431
2009
Kennedy, Charles (2009) Highlights in purinergic signalling. Purinergic Signalling, 5 (3). pp. 265-7. ISSN 1573-9538
2008
Syed, N.H. and Kennedy, C. (2008) Ca2+-signalling pathways involved in P2X receptor-induced contractions of rat small pulmonary artery. Fundamental and Clinical Pharmacology, 22 (S2). p. 76. ISSN 0767-3981
Tengah, A. and Kennedy, C. (2008) Characterisation of the effects of the phospholipase c inhibitor U73122 on P2Y receptor-mediated contractions of the rat isolated pulmonary artery. Fundamental and Clinical Pharmacology, 22 (S2). p. 60. ISSN 0767-3981
Syed, N.H. and Kennedy, C. (2008) The role of ca2+ sensitisation in p2x receptor-induced contractions of rat small pulmonary artery. Fundamental and Clinical Pharmacology, 22. pp. 69-79. ISSN 0767-3981
Kennedy, Charles and Syed, Nawazish-i-Husain (2008) Ca2+-signalling pathways involved in P2X receptor-induced contractions of rat small pulmonary artery. Purinergic Signalling, 4 (S1). S201-S201. ISSN 1573-9538
Kennedy, Charles and Tengah, Asrin (2008) Characterisation of the effects of the phospholipase c inhibitor U73122 on P2Y receptor-mediated contractions of the rat isolated pulmonary artery. Purinergic Signalling, 4 (Supple). S80-S81. ISSN 1573-9538
Kennedy, C. (2008) Is there a role for P2 receptors other than the P2X1 subtype in parasympathetic cotransmission in the urinary bladder? Purinergic Signalling, 4. S200-S200. ISSN 1573-9538
Kennedy, C. and Syed, N.I.H. (2008) The role of ca2+sensitisation in p2x receptor-induced contractions of rat small pulmonary artery. Purinergic Signalling, 4. S200-S201. ISSN 1573-9538
Kennedy, Charles; (2008) P2X3 receptors and sensory transduction. In: Sensing with Ion Channels. Springer Series in Biophysics, 11 . Springer, Berlin, Germany, pp. 247-266. ISBN 978-3-540-72683-8
2007
Kennedy, Charles and Tasker, Paul N. and Gallagher, Gemma and Westfall, Timothy D. (2007) Identification of atropine-and P2X1 receptor antagonist-reistant, neurogenic contractions of the urinary bladder. Journal of Neuroscience, 27 (4). pp. 845-851. ISSN 0270-6474
2005
Chootip, Krongkarn and Gurney, Alison M. and Kennedy, Charles (2005) Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery. Respiratory Research, 6. 124. ISSN 1465-9921
2003
Kennedy, C. and Assis, T.S. and Currie, A.J. and Rowan, E.G. (2003) Crossing the pain barrier: P2 receptors as targets for novel analgesics. Journal of Physiology, 553 (3). pp. 683-694. ISSN 0022-3751
2002
Currie, A.J. and Rowan, E.G. and Kennedy, C. (2002) Characterisation of p2x receptors in rat dorsal root ganglion sensory neurons. Lasers in Medical Science, 137 (Procee). 102P-102P. ISSN 0268-8921
Assis, T.S. and Rowan, E.G. and Kennedy, C. (2002) The sensitivity of sensory neurones to P2 receptor agonists differs in intact and dissociated rat dorsal root ganglia. British Journal of Pharmacology, 135. ISSN 1476-5381 (Unpublished)
Chootip, K. and Ness, K.F. and Wang, Y. and Gurney, A.M. and Kennedy, C. (2002) Regional variation in p2 receptor expression in the rat pulmonary arterial circulation. British Journal of Pharmacology, 137 (5). pp. 637-646. ISSN 1476-5381
2001
Qi, Ai-Dong and Kennedy, C. and Harden, T. Kendall and Nicholas, Robert A. (2001) Differential coupling of the human P2Y11 receptor to phospholipase C and adenylyl cyclase. British Journal of Pharmacology, 132 (1). pp. 318-326. ISSN 1476-5381
Connolly, J.G. and Kennedy, C. (2001) The use of electrophysiology to improve understanding of drug-receptor interactions. Journal of Receptors and Signal Transduction, 21 (2-3). pp. 191-214. ISSN 1532-4281
1998
Rae, M.G. and Rowan, E.G. and Kennedy, C. (1998) Pharmacological properties of p2x(3)-receptors present in neurones of the rat dorsal root ganglia. Lasers in Medical Science, 124 (1). pp. 176-180. ISSN 0268-8921
1996
Rae, M.G. and Rowan, E.G. and Kennedy, C. (1996) Characterisation of p-2x-purinoceptors in neurones of the neonatal rat dorsal root ganglia. British Journal of Pharmacology, 119. P369-P369. ISSN 1476-5381
Robertson, S.J. and Rae, M.G. and Rowan, E.G. and Kennedy, C. (1996) Characterization of a P-2x-purinoceptor in cultured neurones of the rat dorsal root ganglia. British Journal of Pharmacology, 118 (4). pp. 951-956. ISSN 1476-5381
1995
Robertson, S.J. and Rowan, E.R. and Kennedy, C. (1995) Characterization of the electrophysiological actions of P-2-purinoceptor agonists in cultured neurons in the rat. British Journal of Pharmacology, 116 (Supple). P54-P54. ISSN 1476-5381