P2Y11 receptors : properties, distribution and functions

Kennedy, Charles (2017) P2Y11 receptors : properties, distribution and functions. Advances in Experimental Medicine and Biology. ISSN 0065-2598 (In Press)

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    Abstract

    The P2Y11 receptor is a G protein-coupled receptor that is stimulated by endogenous purine nucleotides, particularly ATP. Amongst P2Y receptors it has several unique properties; 1) it is the only human P2Y receptor gene that contains an intron in the coding sequence; 2) the gene does not appear to be present in the rodent genome; 3) it couples to stimulation of both phospholipase C and adenylyl cyclase. Its absence in mice and rats, along with a limited range of selective pharmacological tools, has hampered the development of our knowledge and understanding of its properties and functions. Nonetheless, through a combination of careful use of the available tools, suppression of receptor expression using siRNA and genetic screening for SNPs, possible functions of native P2Y11 receptors have been identified in a variety of human cells and tissues. Many are in blood cells involved in inflammatory responses, consistent with extracellular ATP being a damage-associated signalling molecule in the immune system. Thus proposed potential therapeutic applications relate, in the main, to modulation of acute and chronic inflammatory responses.

    Author(s):Kennedy, Charles ORCID logoORCID: https://orcid.org/0000-0001-9661-5437
    Item type:Article
    ID code:61471
    Keywords:P2Y11 receptor, purine nucleotides, immune system, Pharmacy and materia medica, Biochemistry, Genetics and Molecular Biology(all), Medicine(all)
    Subjects:Medicine > Pharmacy and materia medica
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:03 Aug 2017 15:38
    Last modified:27 Jan 2020 02:56
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/61471
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