Spatial aspects of signalling by sphingosine 1-phosphate
Pyne, S. and Lee, S.C. and Long, J. and Gillies, L. and Pyne, N.J. (2009) Spatial aspects of signalling by sphingosine 1-phosphate. Naunyn-Schmiedeberg's Archives of Pharmacology, 380 (4). p. 369.
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Abstract
Sphingosine kinase (SK) catalyses the phosphorylation of sphingosine to produce sphingosine 1-phosphate (S1P). S1P is a bioactive lipid that regulates cell proliferation, survival, migration etc. Extracellular S1P mediates its effects by binding to a family of five closely related G protein coupled receptors, S1P1-5. In addition, intracellular S1P may bind to undefined intracellular targets to elicit cellular responses. The focus of our recent work has
Creators(s): |
Pyne, S. ![]() ![]() | Item type: | Article |
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ID code: | 18951 |
Keywords: | spatial aspect, s signalling, sphingosine 1-phosphate, Therapeutics. Pharmacology, Pharmacology |
Subjects: | Medicine > Therapeutics. Pharmacology |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
Depositing user: | Strathprints Administrator |
Date deposited: | 22 Jun 2010 08:55 |
Last modified: | 27 Jan 2021 08:40 |
URI: | https://strathprints.strath.ac.uk/id/eprint/18951 |
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