Spatial aspects of signalling by sphingosine 1-phosphate

Pyne, S. and Lee, S.C. and Long, J. and Gillies, L. and Pyne, N.J. (2009) Spatial aspects of signalling by sphingosine 1-phosphate. Naunyn-Schmiedeberg's Archives of Pharmacology, 380 (4). p. 369.

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Official URL: https://doi.org/10.1007/s00210-009-0430-z

Abstract

Sphingosine kinase (SK) catalyses the phosphorylation of sphingosine to produce sphingosine 1-phosphate (S1P). S1P is a bioactive lipid that regulates cell proliferation, survival, migration etc. Extracellular S1P mediates its effects by binding to a family of five closely related G protein coupled receptors, S1P1-5. In addition, intracellular S1P may bind to undefined intracellular targets to elicit cellular responses. The focus of our recent work has

Author(s):	Pyne, S. ORCID: https://orcid.org/0000-0002-6608-9584, Lee, S.C., Long, J., Gillies, L. and Pyne, N.J. ORCID: https://orcid.org/0000-0002-5657-4578
Item type:	Article
ID code:	18951
Keywords:	spatial aspect, s signalling, sphingosine 1-phosphate, Therapeutics. Pharmacology, Pharmacology
Subjects:	Medicine > Therapeutics. Pharmacology
Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user:	Strathprints Administrator
Date deposited:	22 Jun 2010 08:55
Last modified:	21 Jan 2020 01:31
URI:	https://strathprints.strath.ac.uk/id/eprint/18951
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