Does the sphingosine 1-phosphate receptor-1 provide a better or worse prognostic outcome for breast cancer patients?

Pyne, Nigel J. and Pyne, Susan (2018) Does the sphingosine 1-phosphate receptor-1 provide a better or worse prognostic outcome for breast cancer patients? Frontiers in Oncology, 8 (417). pp. 1-3. ISSN 2234-943X

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    Abstract

    Recently, Lei et al., (2018) published an article in Cancer Medicine claiming a survival benefit of sphingosine 1-phosphate (S1P) and sphingosine 1-phosphate receptor 1 (S1P1) expression in breast cancer patients. This controversial study opposes the prevailing view concerning the deleterious role of S1P in cancer. This is discussed in depth in the current opinion article.