Sphingosine 1-phosphate receptors and sphingosine kinase 1 : novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers
Pyne, Susan and Edwards, Joanne and OHOTSKI, Jan and Pyne, Nigel J. (2012) Sphingosine 1-phosphate receptors and sphingosine kinase 1 : novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers. Frontiers in Oncology, 2. 168. (https://doi.org/10.3389/fonc.2012.00168)
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Abstract
There is substantial evidence for a role in cancer of the bioactive lipid sphingosine 1-phosphate (S1P), the enzyme sphingosine kinase 1 (that catalyses S1P formation) and S1P-specific G protein-coupled receptors. This perspective highlights recent findings demonstrating that sphingosine kinase 1 and S1P receptors are new important biomarkers for detection of early cancer and progression to aggressive cancer. The impact of the sub-cellular distribution of S1P metabolizing enzymes and S1P receptors and their spatial functional interaction with oncogenes is considered with respect to prognostic outcome. These findings suggest that S1P, in addition to being a biomarker of clinical prognosis, might also be a new therapeutic target for intervention in cancer.
ORCID iDs
Pyne, Susan ORCID: https://orcid.org/0000-0002-6608-9584, Edwards, Joanne, OHOTSKI, Jan and Pyne, Nigel J. ORCID: https://orcid.org/0000-0002-5657-4578;-
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Item type: Article ID code: 42716 Dates: DateEvent3 December 2012PublishedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 04 Feb 2013 15:09 Last modified: 06 Sep 2024 00:38 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/42716