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2024

Riley, Christopher and Ammar, Usama and Alsfouk, Aisha and Anthony, Nahoum G. and Baiget, Jessica and Berretta, Giacomo and Breen, David and Huggan, Judith and Lawson, Christopher and McIntosh, Kathryn and Plevin, Robin and Suckling, Colin J. and Young, Louise C. and Paul, Andrew and Mackay, Simon P. (2024) Design and synthesis of novel aminoindazole-pyrrolo[2,3-b]pyridine inhibitors of IKKα that selectively perturb cellular non-canonical NF-κB signalling. Molecules, 29 (15). 3515. ISSN 1420-3049

2022

Amin, Kamelia M and El-Badry, Ossama M and Abdel Rahman, Doaa E and Abdellattif, Magda H and Abourehab, Mohammed A S and El-Maghrabey, Mahmoud H and Elsaid, Fahmy G and El Hamd, Mohamed A and Elkamhawy, Ahmed and Ammar, Usama M (2022) Scaffold repurposing reveals new nanomolar phosphodiesterase type 5 (PDE5) inhibitors based on pyridopyrazinone scaffold : investigation of in vitro and in silico properties. Pharmaceutics, 14 (9). 1954. ISSN 1999-4923

Elsherbeny, Mohamed H. and Ammar, Usama M. and Abdellattif, Magda H. and Abourehab, Mohammed A. S. and Abdeen, Ahmed and Ibrahim, Samah F and Abdelrahaman, Doaa and Mady, Wessam and Roh, Eun Joo and Elkamhawy, Ahmed (2022) 2-(3-Bromophenyl)-8-fluoroquinazoline-4-carboxylic acid as a novel and selective aurora A kinase inhibitory lead with apoptosis properties : design, synthesis, in vitro and in silico biological evaluation. Life, 12 (6). 876. ISSN 2075-1729

Ali, Eslam M.H. and Mersal, Karim I. and Ammar, Usama M. and Zaraei, Seyed-Omar and Abdel-Maksoud, Mohammed S. and El-Gamal, Mohammed I. and Haque, Md Mamunul and Das, Tanuza and Kim, Eunice EunKyeong and Lee, Jun-Seok and Lee, Kwan Hyi and Kim, Hee-Kwon and Oh, Chang-Hyun (2022) Structural optimization of 4-(imidazol-5-yl)pyridine derivatives affords broad-spectrum anticancer agents with selective B-RAFV600E/p38α kinase inhibitory activity : synthesis, in vitro assays and in silico study. European Journal of Pharmaceutical Sciences, 171. 106115. ISSN 0928-0987

2021

Mersal, Karim I. and Abdel-Maksoud, Mohammed S. and Ali, Eslam M. H. and Ammar, Usama M. and Zaraei, Seyed-Omar and Kim, Jae-Min and Kim, Su-Yeon and Lee, Kyung-Tae and Lee, Kwan Hyi and Kim, Si-Won and Park, Hyun-Mee and Oh, Chang-Hyun and Ji, Mi-Jung (2021) Design, synthesis, in vitro determination and molecular docking studies of 4-(1-(tert-butyl)-3-phenyl-1H-pyrazol-4-yl) pyridine derivatives with terminal sulfonamide derivatives in LPS-induced RAW264.7 macrophage cells. Medicinal Chemistry Research, 30 (10). pp. 1925-1942. ISSN 1054-2523

Elkamhawy, Ahmed and Ammar, Usama M. and Paik, Sora and Abdellattif, Magda H. and Elsherbeny, Mohamed H. and Lee, Kyeong and Roh, Eun Joo (2021) Scaffold repurposing of in-house small molecule candidates leads to discovery of first-in-class CDK-1/HER-2 dual inhibitors : in vitro and in silico screening. Molecules, 26 (17). 5324. ISSN 1420-3049

Abdel-Maksoud, Mohammed and El-Gamal, Mohammed I. and Lee, Bong S. and Gamal El-Din, Mahmoud M. and Jeon, Hong R. and Kwon, Dow and Ammar, Usama M. and Mersal, Karim I. and Ali, Eslam M. H. and Lee, Kyung-Tae and Yoo, Kyung Ho and Han, Dong Keun and Lee, Jae Kyun and Kim, Garam and Choi, Hong Seok and Kwon, Young Jik and Lee, Kwan Hyi and Oh, Chang-Hyun (2021) Discovery of new Imidazo[2,1‑b]thiazole derivatives as potent pan-RAF inhibitors with promising in vitro and in vivo anti-melanoma activity. Journal of Medicinal Chemistry, 64 (10). pp. 6877-6901. ISSN 0022-2623

Ali, Eslam M.H and El-Telbany, Rania Farag A. and Abdel-Maksoud, Mohammed S. and Ammar, Usama M. and Mersal, Karim I. and Zaraei, Sayed-Omar and El-Gamal, Mohammed I. and Choi, Se-In and Lee, Kyung-Tae and Kim, Hee-Kwon and Lee, Kwan Hyi and Oh, Chang-Hyun (2021) Design, synthesis, biological evaluation, and docking studies of novel (imidazol-5-yl)pyrimidine-based derivatives as dual BRAFV600E/p38α inhibitors. European Journal of Medicinal Chemistry, 215. 113277. ISSN 0223-5234

Ali, Eslam M.H and Abdel-Maksoud, Mohammed S. and Hassan, Rasha Mohamed and Mersal, Karim I. and Ammar, Usama M. and Se-In, Choi and He-Soo, Han and Kim, Hee-Kwon and Lee, Anna and Lee, Kyung-Tae and Oh, Chang-Hyun (2021) Design, synthesis and anti-inflammatory activity of imidazol-5-yl pyridine derivatives as p38α/MAPK14 inhibitor. Bioorganic and Medicinal Chemistry, 31. 115969. ISSN 0968-0896