The iso-secoi-tanapartholides: isolation, synthesis and biological evaluation

Makiyi, E.F. and Frade, R.F.M. and Lebl, T. and Jaffray, E.G. and Cobb, S. and Harvey, Alan L. and Slawin, A.M.Z. and Hay, R.T. (2009) The iso-secoi-tanapartholides: isolation, synthesis and biological evaluation. Agewandte Chemie-International Edition, 2009 (33). pp. 5711-5715. ISSN 1433-7851

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Abstract

The isolation, identification and total synthesis of two plant-derived inhibitors of the NF-κB signaling pathway from the iso-seco-tanapartholide family of natural products is described. A key step in the efficient reaction sequence is a late-stage oxidative cleavage reaction that was carried out in the absence of protecting groups to give the natural products directly. A detailed comparison of the synthetic material with samples of the natural products proved informative. Biological studies on synthetic material confirmed that these compounds act late in the NF-κB signaling pathway.

Author(s):Makiyi, E.F., Frade, R.F.M., Lebl, T., Jaffray, E.G., Cobb, S., Harvey, Alan L., Slawin, A.M.Z. and Hay, R.T.
Item type:Article
ID code:25993
Notes:Strathprints' policy is to record up to 8 authors per publication, plus any additional authors based at the University of Strathclyde. More authors may be listed on the official publication than appear in the Strathprints' record.
Keywords:natural products, total synthesis, terpenoids, cleavage reaction, inflammation, Pharmacy and materia medica, Chemistry(all), Catalysis
Subjects:Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Strathprints Administrator
Date deposited:30 Sep 2010 14:15
Last modified:22 Mar 2019 03:19
URI:https://strathprints.strath.ac.uk/id/eprint/25993
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