The iso-secoi-tanapartholides: isolation, synthesis and biological evaluation

Makiyi, E.F. and Frade, R.F.M. and Lebl, T. and Jaffray, E.G. and Cobb, S. and Harvey, Alan L. and Slawin, A.M.Z. and Hay, R.T. (2009) The iso-secoi-tanapartholides: isolation, synthesis and biological evaluation. Agewandte Chemie-International Edition, 2009 (33). pp. 5711-5715. ISSN 1433-7851 (http://dx.doi.org/10.1002/ejoc.200901016)

Full text not available in this repository.Request a copy

Abstract

The isolation, identification and total synthesis of two plant-derived inhibitors of the NF-κB signaling pathway from the iso-seco-tanapartholide family of natural products is described. A key step in the efficient reaction sequence is a late-stage oxidative cleavage reaction that was carried out in the absence of protecting groups to give the natural products directly. A detailed comparison of the synthetic material with samples of the natural products proved informative. Biological studies on synthetic material confirmed that these compounds act late in the NF-κB signaling pathway.

  • Item type:Article
    ID code:25993
    Dates:
    Date
    Event
    7 October 2009
    Published
    Notes:Strathprints' policy is to record up to 8 authors per publication, plus any additional authors based at the University of Strathclyde. More authors may be listed on the official publication than appear in the Strathprints' record.
    Keywords:natural products, total synthesis, terpenoids, cleavage reaction, inflammation, Pharmacy and materia medica, Chemistry(all), Catalysis
    Subjects:Medicine > Pharmacy and materia medica
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Strathprints Administrator
    Date deposited:30 Sep 2010 14:15
    Last modified:30 Apr 2021 03:11
    URI:https://strathprints.strath.ac.uk/id/eprint/25993
CORE (COnnecting REpositories)