Dendrotoxin-like effects of noxiustoxin

Harvey, A L and Marshall, D L and Possani, L D (1992) Dendrotoxin-like effects of noxiustoxin. Toxicon, 30 (11). pp. 1497-1500. ISSN 1879-3150

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Abstract

Noxiustoxin from the Mexican scorpion (Centruroides noxius Hoffmann) is known to block neuronal K+ channels. Noxiustoxin facilitated acetylcholine release in chick biventer cervicis nerve-muscle preparations, but not in mouse phrenic nerve-hemidiaphragm preparations. Noxiustoxin displaced binding of a radiolabelled dendrotoxin from synaptosomal membranes from rat brain, with a Ki of 10(-10) M. It is concluded that noxiustoxin shares some pharmacological properties with the K+ channel blocking dendrotoxins.

Creators(s): Harvey, A L, Marshall, D L and Possani, L D;
Item type:Article
ID code:31672
Keywords:animals, chick embryo, elapid venoms, iodine radioisotopes, mice, neuromuscular junction, phrenic nerve, potassium channels, rats, respiratory muscles, scorpion venoms, synaptic membranes, synaptosomes, Pharmacy and materia medica, Toxicology
Subjects:Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:13 Jul 2011 08:56
Last modified:20 Jan 2021 19:25
URI:https://strathprints.strath.ac.uk/id/eprint/31672
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