Dendrotoxin-like effects of noxiustoxin
Harvey, A L and Marshall, D L and Possani, L D (1992) Dendrotoxin-like effects of noxiustoxin. Toxicon, 30 (11). pp. 1497-1500. ISSN 1879-3150
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Abstract
Noxiustoxin from the Mexican scorpion (Centruroides noxius Hoffmann) is known to block neuronal K+ channels. Noxiustoxin facilitated acetylcholine release in chick biventer cervicis nerve-muscle preparations, but not in mouse phrenic nerve-hemidiaphragm preparations. Noxiustoxin displaced binding of a radiolabelled dendrotoxin from synaptosomal membranes from rat brain, with a Ki of 10(-10) M. It is concluded that noxiustoxin shares some pharmacological properties with the K+ channel blocking dendrotoxins.
Creators(s): | Harvey, A L, Marshall, D L and Possani, L D; | Item type: | Article |
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ID code: | 31672 |
Keywords: | animals, chick embryo, elapid venoms, iodine radioisotopes, mice, neuromuscular junction, phrenic nerve, potassium channels, rats, respiratory muscles, scorpion venoms, synaptic membranes, synaptosomes, Pharmacy and materia medica, Toxicology |
Subjects: | Medicine > Pharmacy and materia medica |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
Depositing user: | Pure Administrator |
Date deposited: | 13 Jul 2011 08:56 |
Last modified: | 20 Jan 2021 19:25 |
URI: | https://strathprints.strath.ac.uk/id/eprint/31672 |
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