Picture of UK Houses of Parliament

Leading national thinking on politics, government & public policy through Open Access research

Strathprints makes available scholarly Open Access content by researchers in the School of Government & Public Policy, based within the Faculty of Humanities & Social Sciences.

Research here is 1st in Scotland for research intensity and spans a wide range of domains. The Department of Politics demonstrates expertise in understanding parties, elections and public opinion, with additional emphases on political economy, institutions and international relations. This international angle is reflected in the European Policies Research Centre (EPRC) which conducts comparative research on public policy. Meanwhile, the Centre for Energy Policy provides independent expertise on energy, working across multidisciplinary groups to shape policy for a low carbon economy.

Explore the Open Access research of the School of Government & Public Policy. Or explore all of Strathclyde's Open Access research...

Snake peptides

Harvey, A.L. (2013) Snake peptides. In: Handbook of Biologically Active Peptides. Academic Press, pp. 451-460. ISBN 9780123850959

Full text not available in this repository.Request a copy from the Strathclyde author

Abstract

Snake venoms are complex mixtures of small molecules, peptides, and proteins. Most of the biologically active toxins are peptides or enzymes. This chapter covers the nonenzymatically active peptides and toxins. The peptides belong to several structural classes, and they have many different biological actions. The best characterized peptides are the so-called three-finger toxins that have 60–70 amino acid residues in three peptide loops stabilized by four disulfide bridges. Despite their common 3D shape, these peptides can interfere selectively with different biological targets, including nicotinic and muscarinic acetylcholine receptors, acetylcholinesterase, ion channels, and cell membranes. Other small peptides can block K+ or Ca2+ channels and are based on Kunitz serine proteinase inhibitors (~60 amino acid residues and three disulfide bonds), whereas other toxins have different molecular scaffolds and different pharmacological activities. Many snake venom peptides are useful pharmacological tools, whereas others are leads for drug development.