A potassium channel toxin from the secretion of the sea anemone Bunodosoma granulifera. Isolation, amino acid sequence and biological activity
Aneiros, A and García, I and Martínez, J R and Harvey, A L and Anderson, A J and Marshall, D L and Engström, A and Hellman, U and Karlsson, E (1993) A potassium channel toxin from the secretion of the sea anemone Bunodosoma granulifera. Isolation, amino acid sequence and biological activity. BBA - Biochimica et Biophysica Acta, 1157 (1). pp. 86-92. ISSN 0006-3002
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A peptide toxin affecting potassium channels was isolated from the sea anemone Bunodosoma granulifera. It facilitates acetylcholine release at avian neuromuscular junctions, competes with dendrotoxin I, a probe for voltage-dependent potassium channels, for binding to synaptosomal membranes of rat brain with a Ki of 0.7 nM and suppresses K+ currents in rat dorsal root ganglion neurones in culture. It represents a new structural type of potassium channel toxin with the sequence V1RCDWFKETA10CRHAKSLGNC20RTSQKYRANC30AKTLQCC37 (M(r) 4275, three disulfides).
| Creators(s): |
Aneiros, A, García, I, Martínez, J R, Harvey, A L, Anderson, A J  ORCID: https://orcid.org/0000-0003-4151-1619, Marshall, D L, Engström, A, Hellman, U and Karlsson, E;
| Item type: | Article |
|---|---|
| ID code: | 31668 |
| Keywords: | amino acid sequence, animals, cultured cells, chickens, gel chromatography, cnidaria, cnidarian venoms, mass spectrometry, molecular sequence data, neuromuscular junction, potassium channels, rats, amino acid sequence homology, Pharmacy and materia medica |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Engineering > Electronic and Electrical Engineering |
| Depositing user: | Pure Administrator |
| Date deposited: | 13 Jul 2011 08:56 |
| Last modified: | 20 Jan 2021 19:24 |
| URI: | https://strathprints.strath.ac.uk/id/eprint/31668 |
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