Omega-conotoxin does not block the verapamil-sensitive calcium channels at mouse motor nerve terminals

Anderson, A J and Harvey, A L (1987) Omega-conotoxin does not block the verapamil-sensitive calcium channels at mouse motor nerve terminals. Neuroscience Letters, 82 (2). pp. 177-180. ISSN 0304-3940 (https://doi.org/10.1016/0304-3940(87)90125-X)

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Abstract

Release of acetylcholine at the neuromuscular junctions of skeletal muscle is not sensitive to organic Ca2+ channel blockers. However, in mouse motor nerve endings, extracellular recording reveals that a verapamil-sensitive Ca2+ current can be induced after block of K+ channels. Recordings of extracellular action potentials from inside the perineural sheaths of nerves innervating mouse triangularis sterni muscles reveal that this verapamil-sensitive current is not blocked by omega-conotoxin, and hence, it does not involve channels similar to the L-channels of neuronal cell bodies.

  • Item type:Article
    ID code:31690
    Dates:
    Date
    Event
    23 November 1987
    Published
    Keywords:animals, anura, calcium, ion channels, male, mice, inbred BALB C mice, mollusk venoms, nerve block, neuromuscular junction, verapamil, omega-conotoxins, Pharmacy and materia medica, Neuroscience(all)
    Subjects:Medicine > Pharmacy and materia medica
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:13 Jul 2011 08:57
    Last modified:20 Jan 2021 19:25
    URI:https://strathprints.strath.ac.uk/id/eprint/31690
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