The pharmacology of galanthamine and its analogues

Harvey, A L (1995) The pharmacology of galanthamine and its analogues. Pharmacology and Therapeutics, 68 (1). pp. 113-128. ISSN 0163-7258 (https://doi.org/10.1016/0163-7258(95)02002-0)

Abstract

Galanthamine is an alkaloid found in the bulbs of snowdrops and several Amaryllidaceae plants. At submicromolar concentrations, it inhibits acetylcholinesterase activity, but it is much less potent against butyrylcholinesterase activity. Galanthamine has been used in anaesthetics to reverse neuromuscular paralysis by tubocurarine-like muscle relaxants, but it is a tertiary amine that gets into the brain to cause central effects. Galanthamine is being studied as a possible therapeutic agent in Alzheimer's disease because of its central cholinergic effects. Positive effects have been demonstrated in several learning and memory tests in animals.

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  Item type:	Article
  ID code:	31644
  Dates:	Date Event 1995 Published
  Keywords:	animals, central nervous system, cholinesterase inhibitors, galantamine, humans, nootropic agents, parasympathomimetics, Therapeutics. Pharmacology, Pharmacology, Pharmacology (medical)
  Subjects:	Medicine > Therapeutics. Pharmacology
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Pure Administrator
  Date deposited:	13 Jul 2011 08:56
  Last modified:	16 Jul 2021 02:38
  URI:	https://strathprints.strath.ac.uk/id/eprint/31644