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Strathprints

Snake toxins from mamba venoms : unique tools for the physiologist

Rowan, E. G. and Harvey, A. L. (2011) Snake toxins from mamba venoms : unique tools for the physiologist. Acta Chimica Slovenica, 58 (4). pp. 689-692. ISSN 1318-0207

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Abstract

Snake venoms are complex mixtures of small molecules, peptides and proteins. Most of the biologically active toxins are peptides or enzymes. The peptides belong to several structural classes, and they have many different biological actions. The best characterised are the so-called three-finger toxins that have three peptide loops stabilised by four disulphide bridges. Despite their common 3D shape, these peptides can interfere selectively with different biological targets, including nicotinic and muscarinic acetylcholine receptors, acetylcholinesterase, ion channels, and cell membranes. Other small peptides can block K(+) or Ca(2+) channels and are based on Kunitz serine proteinase inhibitors. This article summarises the proteins and peptides isolated from venoms of mamba snakes ( Dendroaspis genus) that have been useful as experimental tools for physiologists and pharmacologists.

Item type: Article
ID code: 41953
Keywords: gene organization, mamba toxins, muscarinic toxins, peptide, nicotinic acetylcholine-receptors, bungarotoxin, neurotoxin, alpha-7, mamba venom, natriuretic peptides, calciseptine, receptor, antagonist, proteins, green mamba, ion channel, snake toxins, physiologist, tools, Pharmacy and materia medica, Chemistry, Chemistry(all)
Subjects: Medicine > Pharmacy and materia medica
Science > Chemistry
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited: 08 Nov 2012 10:59
Last modified: 29 Mar 2019 03:18
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URI: https://strathprints.strath.ac.uk/id/eprint/41953
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