Synthesis of 4-(Carbonyloxyphenyl)-1,4-dihydropyridines as potential antihypertensive agents
Bansal, R. and Narang, G. and Calle, C. and Carron, R. and Pemberton, K. and Harvey, A.L. (2013) Synthesis of 4-(Carbonyloxyphenyl)-1,4-dihydropyridines as potential antihypertensive agents. Drug Development Research, 74 (1). pp. 50-61. ISSN 0272-4391 (https://doi.org/10.1002/ddr.21056)
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Preclinical Research A series of novel symmetric and asymmetric 4-(carbonyloxyphenyl)-1,4-dihydropyridines (DHPs) was synthesized and evaluated for calcium channel blocking, vasodilatory and antihypertensive properties. Some of these new DHPs displayed potent calcium channel blocking and good vasodilatory activities. Heart rate remained relatively constant in comparison with blood pressure changes in the case of these newly synthesized compounds, thereby decreasing the probability of reflex tachycardia, a major side effect of nifedipine. The most potent compound, ethyl methyl 4-(3- isopropylcarbonyloxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (14c) exhibited antihypertensive activity comparable with the standard drug - nifedipine.
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Item type: Article ID code: 45406 Dates: DateEvent1 February 2013PublishedSubjects: Medicine > Therapeutics. Pharmacology Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 25 Oct 2013 11:17 Last modified: 29 Sep 2024 05:36 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/45406