Efecto inhibidor del extracto acuoso de hojas de Persea americana Mill y sus fracciones sobre PTP1B como diana terapéutica para la diabetes tipo 2

Marrero-Faz, Evangelina and Sánchez-Calero, Janet and Young, Louise and Harvey, Alan (2014) Efecto inhibidor del extracto acuoso de hojas de Persea americana Mill y sus fracciones sobre PTP1B como diana terapéutica para la diabetes tipo 2. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 13 (2). pp. 144-151.

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    Abstract

    Persea Americana Mill (Lauraceae), is a popular plant in Cuba due to its nutritional and medicinal properties. The fruit of the plant is commonly known as avocado. The leaves of Persea americana Mill have been popularly used in the treatment of diabetes in countries in Latin America and Africa. The present study is aimed to explore one of the underlying mechanisms that mediate the antidiabetic efficacy of Persea americana Mill. The aqueous extract from the leaves of the plant and its fractions were evaluated on the inhibitory activity of the protein tyrosine phosphatase 1B (PTP1B) as target of type 2 diabetes. The results revealed that aqueous extract from P americana inhibited the enzymatic activity of PTP1B in an extract concentration dependent manner, resulting mainly active the most polar fraction. The present research demonstrated that aqueous extract from P americana and polar fraction (PaF10) have promissory antidiabetic properties mediated by PTP1B, which is a relevant mechanism involved on insulin resistance in type 2 diabetes.