Picture of boy being examining by doctor at a tuberculosis sanatorium

Understanding our future through Open Access research about our past...

Strathprints makes available scholarly Open Access content by researchers in the Centre for the Social History of Health & Healthcare (CSHHH), based within the School of Humanities, and considered Scotland's leading centre for the history of health and medicine.

Research at CSHHH explores the modern world since 1800 in locations as diverse as the UK, Asia, Africa, North America, and Europe. Areas of specialism include contraception and sexuality; family health and medical services; occupational health and medicine; disability; the history of psychiatry; conflict and warfare; and, drugs, pharmaceuticals and intoxicants.

Explore the Open Access research of the Centre for the Social History of Health and Healthcare. Or explore all of Strathclyde's Open Access research...

Image: Heart of England NHS Foundation Trust. Wellcome Collection - CC-BY.

Strathprints

High-throughput screening of natural products for cancer therapy

Harvey, Alan L and Cree, Ian A (2010) High-throughput screening of natural products for cancer therapy. Planta Medica, 76 (11). pp. 1080-1086.

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

Natural products have been the biggest single source of anticancer drugs and there are continued efforts to explore the chemical diversity provided by nature in order to find new lead compounds. Bioassay test methods have developed into high throughput screening assays using both cell-based and molecular approaches. The various ways to detect effects on cell viability and cell proliferation are summarised and examples are given of developments using three-dimensional cultures and cancer stem cells. Cell-based reporter assays have also been created in order to look more directly for effects on specific physiological pathways. The molecular assays include those directed at microtubules and related proteins and at many different protein kinases.

Item type: Article
ID code: 31588
Notes: Georg Thieme Verlag KG Stuttgart-New York.
Keywords: antineoplastic agents, biological assay, cell culture techniques, cell proliferation, cell survival, genes, high-throughput screening Assays, luciferases, protein kinase inhibitors, substrate specificity, tubulin modulators, tumor cells, cultured, reporter, phytogenic, Biology, Pharmacy and materia medica, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
Subjects: Science > Natural history > Biology
Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited: 23 Jun 2011 11:43
Last modified: 03 Jan 2019 12:57
Related URLs:
URI: https://strathprints.strath.ac.uk/id/eprint/31588
Export data:
CORE (COnnecting REpositories)