Natural products as a screening resource
Harvey, Alan L (2007) Natural products as a screening resource. Current Opinion in Chemical Biology, 11 (5). pp. 480-484. ISSN 1367-5931
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Natural products have been the most productive source of leads for new drugs, but they are currently out of fashion with the pharmaceutical industry. New approaches to sourcing novel compounds from untapped areas of biodiversity coupled with the technical advances in analytical techniques (such as microcoil NMR and linked LC-MS-NMR) have removed many of the difficulties in using natural products in screening campaigns. As the 'chemical space' occupied by natural products is both more varied and more drug-like than that of combinatorial chemical collections, synthetic and biosynthetic methods are being developed to produce screening libraries of natural product-like compounds. A renaissance of drug discovery inspired by natural products can be predicted.
| Author(s): | Harvey, Alan L | Item type: | Article |
|---|---|
| ID code: | 31601 |
| Keywords: | biodiversity, biological products, analytical chemistry techniques, preclinical drug evaluation , drug industry, Pharmacy and materia medica, Biochemistry, Analytical Chemistry |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Depositing user: | Pure Administrator |
| Date deposited: | 16 Nov 2011 15:29 |
| Last modified: | 06 Sep 2019 03:07 |
| URI: | https://strathprints.strath.ac.uk/id/eprint/31601 |
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