Natural products as a screening resource

Harvey, Alan L (2007) Natural products as a screening resource. Current Opinion in Chemical Biology, 11 (5). pp. 480-484. ISSN 1367-5931 (https://doi.org/10.1016/j.cbpa.2007.08.012)

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Abstract

Natural products have been the most productive source of leads for new drugs, but they are currently out of fashion with the pharmaceutical industry. New approaches to sourcing novel compounds from untapped areas of biodiversity coupled with the technical advances in analytical techniques (such as microcoil NMR and linked LC-MS-NMR) have removed many of the difficulties in using natural products in screening campaigns. As the 'chemical space' occupied by natural products is both more varied and more drug-like than that of combinatorial chemical collections, synthetic and biosynthetic methods are being developed to produce screening libraries of natural product-like compounds. A renaissance of drug discovery inspired by natural products can be predicted.

  • Item type:Article
    ID code:31601
    Dates:
    Date
    Event
    October 2007
    Published
    19 September 2007
    Published Online
    Keywords:biodiversity, biological products, analytical chemistry techniques, preclinical drug evaluation , drug industry, Pharmacy and materia medica, Biochemistry, Analytical Chemistry
    Subjects:Medicine > Pharmacy and materia medica
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:16 Nov 2011 15:29
    Last modified:20 Aug 2021 03:03
    URI:https://strathprints.strath.ac.uk/id/eprint/31601
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