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McFarlane, Emma and Mokgethi, Thabang and Kaye, Paul M. and Hurdayal, Ramona and Brombacher, Frank and Alexander, James and Carter, Katharine C. (2019) IL-4 mediated resistance of BALB/c mice to visceral leishmaniasis is independent of IL-4Rα signaling via T cells. Frontiers in Immunology, 10. 1957. ISSN 1664-3224

Neamatallah, Thikryat and Jabbar, Shilan and Tate, Rothwelle and Schroeder, Juliane and Shweash, Muhannad and Alexander, James and Plevin, Robin (2019) Whole genome microarray analysis of DUSP4-deletion reveals a novel role for MAP kinase phosphatase-2 (MKP-2) in macrophage gene expression and function. International Journal of Molecular Sciences, 20 (14). 3434. ISSN 1422-0067

Schroeder, Juliane and Ross, Kirsty and McIntosh, Kathryn and Jabbar, Shilan Khayrula Jabbar and Woods, Stuart and Crowe, Jenny and Patterson-Kane, Janet C and Alexander, James and Lawrence, Catherine and Plevin, Robin (2019) Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis. RMD Open, 5 (1). e000711. e000711. ISSN 2056-5933

Cano, Antonella and Mattana, Antonella and Henriquez, Fiona L. and Alexander, James and Roberts, Craig W. (2018) Acanthamoeba proteases contribute to macrophage activation through PAR1, but not PAR2. Parasite Immunology. e12612. ISSN 0141-9838

Cano, Antonella and Mattana, Antonella and Woods, Stuart and Henriquez, Fiona L. and Alexander, James and Roberts, Craig W. (2017) Acanthamoeba activates macrophages predominantly through toll-like receptor 4 and MyD88-dependent mechanisms to induce Interleukin IL-12 and IL-6. Infection and Immunity, 85 (6). e01054-16. ISSN 0019-9567

Bobat, Saeeda and Darby, Matthew and Mrdjen, Dunja and Cook, Charlotte and Logan, Erin and Auret, Jennifer and Jones, Elizabeth and Schnoeller, Corinna and Flores-Langarica, Adriana and Ross, Ewan A. and Vira, Alykhan and López-Macías, Constantino and Henderson, Ian R. and Alexander, James and Brombacher, Frank and Horsnell, William G. and Cunningham, Adam F. (2014) Natural and vaccine-mediated immunity to Salmonella Typhimurium is impaired by the helminth Nippostrongylus brasiliensis. PLOS Neglected Tropical Diseases, 8 (12). e3341. ISSN 1935-2727

Stevenson, Ross and McAughtrie, Sarah and Senior, Laura and Stokes, Robert J and McGachy, Helen and Tetley, Laurence and Nativo, Paola and Brewer, James M and Alexander, James and Faulds, Karen and Graham, Duncan (2013) Analysis of intracellular enzyme activity by surface enhanced Raman scattering. Analyst, 138 (21). pp. 6331-6336.

Auderset, Floriane and Schuster, Steffen and Fasnacht, Nicolas and Coutaz, Manuel and Charmoy, Mélanie and Koch, Ute and Favre, Stéphanie and Wilson, Anne and Trottein, François and Alexander, James and Luther, Sanjiv A and Macdonald, H Robson and Radtke, Freddy and Tacchini-Cottier, Fabienne (2013) Notch signaling regulates follicular helper T cell differentiation. Journal of Immunology, 191 (5). pp. 2344-2350.

Roberts, Craig and McLeod, Rima and Henriquez, Fiona and Alexander, James; Weiss, Louis M. and Kim, Kami, eds. (2013) Vaccination against Toxoplasmosis : current status and future prospects. In: Toxoplasma Gondii. PERGAMON-ELSEVIER SCIENCE LTD, London, 995–1045. ISBN 9780123964816

Pushparaj, Peter N. and Li, Dong and Komai-Koma, Mousa and Guabiraba, Rodrigo and Alexander, James and McSharry, Charles and Xu, Damo (2013) Interleukin-33 exacerbates acute colitis via interleukin-4 in mice. Immunology, 140 (1). pp. 70-77.

Woods, Stuart and Schroeder, Juliane and McGachy, Helen A and Plevin, Robin and Roberts, Craig W and Alexander, James (2013) MAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in mice. PLOS Pathogens, 9 (8). e1003535.

Sommerville, Caroline and Richardson, Julia M and Williams, Roderick A M and Mottram, Jeremy C and Roberts, Craig W and Alexander, James and Henriquez, Fiona L (2013) Biochemical and immunological characterization of Toxoplasma gondii macrophage migration inhibitory factor. Journal of Biological Chemistry, 288 (18). pp. 12733-12741. ISSN 1083-351X

Schroeder, Juliane and McGachy, H Adrienne and Woods, Stuart and Plevin, Robin and Alexander, James (2013) T cell hypo-responsiveness against Leishmania major in MAP kinase phosphatase (MKP) 2 deficient C57BL/6 mice does not alter the healer disease phenotype. PLOS Neglected Tropical Diseases, 7 (2). e2064.

Komai-Koma, M and Brombacher, F and Pushparaj, P N and Arendse, B and McSharry, C and Alexander, J and Chaudhuri, R and McKenzie, A N J and McInnes, I and Liew, F Y and Xu, D and Thompson, N.C (2012) Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice. Allergy, 67 (9). pp. 1118-1126.

Schroeder, J. and Ross, K. and Alexander, J. and Lawrence, C. E. and Plevin, R. (2012) Protective role of MAP kinase phosphatase 2 (MKP-2) in a model of collagen antibody induced arthritis. Immunology, 137 (1 spec). p. 585. ISSN 0019-2805

Alexander, J. and Brombacher, F. (2012) T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection : is this paradigm still relevant? Frontiers in Immunology, 3 (APR). 80.

Menzies, Fiona M and Henriquez, Fiona L and Alexander, James and Roberts, Craig W (2011) Selective inhibition and augmentation of alternative macrophage activation by progesterone. Immunology, 134 (3). pp. 281-291.

Shweash, Muhannad and Adrienne McGachy, H and Schroeder, Juliane and Neamatallah, Thikryat and Bryant, Clare E and Millington, Owain and Mottram, Jeremy C and Alexander, James and Plevin, Robin (2011) Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2, iNOS and arginase-1 expression. Molecular Immunology, 48 (15-16). pp. 1800-1808.

McFarlane, Emma and Carter, Katharine C and McKenzie, Andrew N and Kaye, Paul M and Brombacher, Frank and Alexander, James (2011) Endogenous IL-13 plays a crucial role in liver granuloma maturation during Leishmania donovani infection, independent of IL-4R alpha-responsive macrophages and neutrophils. Journal of Infectious Diseases, 204 (1). pp. 36-43.

Bobat, Saeeda and Flores-Langarica, Adriana and Hitchcock, Jessica and Marshall, Jennifer L. and Kingsley, Robert A and Goodall, Margaret and Gil-Cruz, Cristina and Serre, Karine and Leyton, Denisse L and Letran, Shirdi E and Gaspal, Fabrina and Chester, Rebecca and Chamberlain, Jayne L. and Dougan, Gordon and López-Macías, Constantino and Henderson, Ian R. and Alexander, James and MacLennan, Ian C M and Cunningham, Adam F. (2011) Soluble flagellin, FliC, induces an Ag-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella typhimurium infection. European Journal of Immunology, 41 (6). pp. 1606-1618.

Bryson, Karen and Millington, Owain and Mokgethi, Thabang and McGachy, Adrienne and Brombacher, Frank and Alexander, James (2011) BALB/c mice deficient in CD4(+) T cell IL-4R alpha expression control Leishmania mexicana load although female but not male mice develop a healer phenotype. PLOS Neglected Tropical Diseases, 5 (1). pp. 1-10. e930. ISSN 1935-2727

Millington, Owain and Myburgh, E and Mottram, Jeremy and Alexander, James (2010) Imaging of the host/parasite interplay in cutaneous leishmaniasis. Experimental Parasitology, 126 (3). pp. 310-317. ISSN 0014-4894

Al-Mutairi, M.S. and Cadalbert, L.C. and McGachy, H.A. and Shweash, M.S. and Schroeder, J. and Kurnik, M. and Sloss, C.M. and Bryant, C.E. and Alexander, James and Plevin, R.J. (2010) MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana. PLOS Pathogens, 6 (11). e1001192. ISSN 1553-7366

Jones, Leigh A. and Kreem, Shrook and Shweash, Muhannad and Paul, Andrew and Alexander, James and Roberts, Craig W. (2010) Differential modulation of TLR-3 and TLR-4 mediated dendritic cell maturation and function by progesterone. Journal of Immunology, 185 (8). pp. 4525-4534. ISSN 0022-1767

Menzies, F.M. and Henriquez, F.L. and Alexander, J. and Roberts, C.W. (2010) Sequential expression of macrophage anti-microbial/inflammatory and wound healing markers following innate, alternative and classical activation. Clinical and Experimental Immunology, 160 (3). pp. 369-379. ISSN 0009-9104

Henriquez, Selina A. and Thompson, David M. and Henriquez, Fiona L. and Alexander, James and Pratt, Judith and Brett, Ros and Roberts, Craig W. (2010) Is there a relationship between toxoplasma gondii and psychiatric disorders? Schizophrenia Research, 117 (2-3). pp. 389-390. ISSN 0920-9964

Jones, L.A. and Roberts, F. and Nickdel, M.B. and Brombacher, F. and McKenzie, Andrew N.J. and Henriquez, F.L. and Alexander, J. and Roberts, C.W. (2010) IL-33 receptor (T1/ST2) signalling is necessary to prevent the development of encephalitis in mice infected with Toxoplasma gondii. European Journal of Immunology, 40 (2). pp. 426-436. ISSN 0014-2980

Alexander, J. and Irving, K. and Snider, H. and Satoskar, A.; Klein, Sabra L. and Roberts, Craig W., eds. (2010) Sex hormones and regulation of host responses against parasites. In: Sex Hormones and Immunity to Infection. Springer, pp. 147-186. ISBN 978-3-642-02154-1

Michels, Chesney E. and Scales, Hannah E. and Saunders, Karin A. and McGowan, S. and Brombracher, Frank and Alexander, James and Lawrence, Catherine E. (2009) Neither interleukin-4 receptor α expression on CD4+ T cells, or macrophages and neutrophils is required for protective immunity to Trichinella spiralis. Immunology, 128 (1pt2). e385-e394. ISSN 0019-2805

Bryson, K.J. and Besteiro, Sébastien and McGachy, H.A. and Coombs, G.H. and Mottram, J.C. and Alexander, J. (2009) Overexpression of the natural inhibitor of cysteine peptidases in Leishmania mexicana leads to reduced virulence and a Th1 response. Infection and Immunity, 77 (7). pp. 2971-2978. ISSN 0019-9567

Mann, Jamie F S and Shakir, Eisin and Carter, Katharine C and Mullen, Alexander B and Alexander, James and Ferro, Valerie A (2009) Lipid vesicle size of an oral influenza vaccine delivery vehicle influences the Th1/Th2 bias in the immune response and protection against infection. Vaccine, 27 (27). pp. 3643-3649. ISSN 1873-2518

Graham, D. and Faulds, Karen and Thompson, David and McKenzie, Fiona and Stokes, Robert J. and Dalton, Colette and Stevenson, Ross and Alexander, J. and Garside, Paul and McFarlane, Emma (2009) Functionalized nanoparticles for bioanalysis by SERRS. Biochemical Society Transactions, 37. pp. 697-701. ISSN 0300-5127

Menzies, Fiona M. and Henriquez, F.L. and Alexander, J. and Roberts, Craig (2009) Modulation of macrophage arginase gene expression and activity by progesterone. Reproductive Sciences, 16 (3 (Sup). 119A-119A. ISSN 1933-7191

Henriquez, S.A. and Brett, Ros and Alexander, J. and Pratt, Judith and Roberts, C.W. (2009) Neuropsychiatric disease and toxoplasma gondii infection. Neuroimmunomodulation, 16 (2). pp. 122-133. ISSN 1021-7401

Stokes, Robert J. and McKenzie, Fiona and McFarlane, Emma and Ricketts, Alastair and Tetley, L. and Faulds, Karen and Alexander, J. and Graham, Duncan (2009) Rapid cell mapping using nanoparticles and SERRS. Analyst, 134 (1). pp. 170-175. ISSN 0003-2654

Snider, Heidi and Lezama-Davila, Claudio and Alexander, J. and Satoskar, Abhay R. (2009) Sex hormones and modulation of immunity against leishmaniasis. Neuroimmunomodulation, 16 (2). pp. 106-113. ISSN 1021-7401

Mokgethi, T. and Nickdel, M.B. and Henriquez, F.L. and Roberts, F. and Brombacher, F. and Roberts, Craig and Alexander, J. (2008) The role of IL-4R alpha signalling during toxoplasma gondii infection. Immunology, 125 (s1). p. 110. OP 105. ISSN 0019-2805

Alexander, J. and McFarlane, Emma (2008) Can type-1 responses against intracellular pathogens be T helper 2 cytokine dependent? Microbes and Infection, 10 (9). pp. 953-959. ISSN 1286-4579

McFarlane, E. and Perez, C. and Charmoy, M. and Allenbach, C. and Carter, K.C. and Alexander, J. and Tacchini-Cottier, F. (2008) Neutrophils contribute to development of a protective immune response during onset of infection with Leishmania donovani. Infection and Immunity, 76 (2). pp. 532-541. ISSN 0019-9567

Jones, L.A. and Anthony, J. and Henriquez, F.L. and Lyons, R. and Nickdel, M.B. and Carter, K.C. and Alexander, J. and Roberts, C.W. (2008) Toll-like receptor-4-mediated macrophage activation is differentially regulated by progesterone via the glucocorticoid and progesterone receptors. Immunology, 125 (1). pp. 59-69. ISSN 0019-2805

Alexander, J. and Bryson, K.J. and Wei, X. (2008) Interleukin-18 enhances a Th2 biased response and susceptibility to leishmania mexicana in BALB/c mice. Microbes and Infection, 10 (7). pp. 834-839. ISSN 1286-4579

Radwanska, Magdalena and Cutler, Antony J. and Hoving, J. Claire and Magez, Stefan and Holscher, Christoph and Bohms, Andreas and Arendse, Berenice and Kirsch, Richard and Hunig, Thomas and Alexander, James and Kaye, Paul and Brombacher, Frank (2007) Deletion of IL-4Rα on CD4 T cells renders BALB/c mice resistant to Leishmania major infection. PLOS Pathogens, 3 (5). 0619-0629. e68. ISSN 1553-7366

Schaap, D. and Vermeulen, A.N. and Roberts, C.W. and Alexander, J.; (2007) Vaccination against toxoplasmosis: current status and future prospects. In: Toxoplasma gondii the Model Apicomplexan - Perspective and Methods. Academic Press, pp. 721-760. ISBN 0123695422

Jones, L.A. and Alexander, J. and Roberts, C.W. (2006) Ocular toxoplasmosis : in the storm of the eye. Parasite Immunology, 28 (12). pp. 635-642. ISSN 0141-9838

Alexander, J. and Mann, J.F.S. and Scales, H.E. and Shakir, E. and Carter, K.C. and Mullen, A. and Ferro, V.A. (2006) Oral delivery of tetanus toxoid using vesicles containing bile salts (bilosomes) induces significant systemic and mucosal immunity. Methods, 38 (2). pp. 90-95. ISSN 1046-2023

Alexander, J. and Graham, D. (2006) New probes and optical spectroscopies for immune parasitological applications. Parasite Immunology, 28 (6). pp. 236-237. ISSN 0141-9838

Carter, K.C. and Ferro, V.A. and Alexander, J. and Mullen, A. (2006) Translation of an experimental oral vaccine formulation into a commercial product. Methods, 38 (2). pp. 65-68. ISSN 1046-2023

Couper, K N and Roberts, C W and Brombacher, F and Alexander, J and Johnson, L L (2005) Toxoplasma gondii-specific immunoglobulin M limits parasite dissemination by preventing host cell invasion. Infection and Immunity, 73 (12). pp. 8060-8068. ISSN 0019-9567

Cameron, P. and McGachy, H.A. and Anderson, M. and Paul, A. and Coombs, G.H. and Mottram, J.C. and Alexander, J. and Plevin, R.J. (2004) Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway. Journal of Immunology, 173 (5). pp. 3297-3304. ISSN 0022-1767

Nickdel, M. B. and Lyons, R. E. and Roberts, F. and Brombacher, F. and Hunter, C. A. and Alexander, J. and Roberts, C. W. (2004) Intestinal pathology during acute toxoplasmosis is IL-4 dependent and unrelated to parasite burden. Parasite Immunology, 26 (2). pp. 75-82. ISSN 0141-9838

Mann, J.F.S. and Ferro, V.A. and Mullen, A. and Tetley, L. and Mullen, M. and Carter, K.C. and Alexander, J. and Stimson, W.H. (2004) Optimisation of a lipid based oral delivery system containing A/Panama influenza haemagglutinin. Vaccine, 22 (19). pp. 2425-2429. ISSN 1873-2518

Pollock, K.G.J. and McNeil, K.S. and Mottram, J.C. and Lyons, R.E. and Brewer, J.M. and Scott, P. and Coombs, G.H. and Alexander, J. (2003) The Leishmania mexicana cysteine protease, CPB2.8, induces potent Th2 responses. Journal of Immunology, 170 (4). pp. 1746-1753. ISSN 0022-1767

Couper, Kevin N and Nielsen, Henrik V and Petersen, Eskild and Roberts, Fiona and Roberts, Craig W and Alexander, James (2003) DNA vaccination with the immunodominant tachyzoite surface antigen (SAG-1) protects against adult acquired Toxoplasma gondii infection but does not prevent maternofoetal transmission. Vaccine, 21 (21-22). pp. 2813-2820. ISSN 1873-2518

Stager, S. and Alexander, J. and Kirby, A.C. and Botto, M. and Van Rooijen, N. and Smith, D.F. and Brombacher, F. and Kaye, P.M. (2003) Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ t cell responses. Nature Medicine, 9. pp. 1287-1292. ISSN 1078-8956

Padigel, U.M. and Alexander, J. and Farrell, J.P. (2003) The role of Interleukin-10 in susceptibility of BALB/c mice to infection with Leishmania mexicana and Leishmania amazonensis. Journal of Immunology, 171. pp. 3705-3710. ISSN 0022-1767

Alexander, James and Brombacher, Frank and McGachy, H.A. and McKenzie, A.N.J. and Walker, W. and Carter, K.C. (2002) An essential role for IL-13 in maintaining a non-healing response following leishmania mexicana infection. European Journal of Immunology, 32 (10). pp. 2923-2933. ISSN 0014-2980

Roberts, C W and Walker, W and Alexander, J (2001) Sex-associated hormones and immunity to protozoan parasites. Clinical Microbiology Reviews, 14 (3). pp. 476-491. ISSN 0893-8512

Lyons, R. and Anthony, J.P. and Ferguson, D.J.P. and Byrne, N. and Alexander, J. and Roberts, F. and Roberts, C.W. (2001) Immunological studies of chronic ocular toxoplasmosis : up-regulation of major histocompatibility complex class I and transforming growth factor beta and a protective role for interleukin-6. Infection and Immunity, 69 (4). pp. 2589-2595. ISSN 0019-9567

Nickdel, M.B. and Roberts, F. and Brombacher, F. and Alexander, J. and Roberts, C.W. (2001) Counter-protective role for interleukin-5 during acute Toxoplasma Gondii infection. Infection and Immunity, 69 (2). pp. 1044-1052. ISSN 0019-9567

Alexander, J. and Roberts, C. W. and Walker, W. and Reichmann, G. and Hunter, C. A.; Ambroise-Thomas, Pierre and Peterson, Eskild, eds. (2000) The immunology of Toxoplasma gondii infection in the immune-competent host. In: Congenital Toxoplasmosis. Springer, Paris, pp. 69-82. ISBN 9782817808475

Alexander, J. and Jebbari, H. and Bluethmann, H. and Brombacher, F. and Roberts, C.W. (1998) The role of IL-4 in adult acquired and congenital toxoplasmosis. International Journal for Parasitology, 28 (1). pp. 113-120. ISSN 0020-7519

Roberts, C.W. and Satoskar, A. and Alexander, J. (1996) Sex-steroids, pregnancy-associated hormones and immunity to parasitic infection. Parasitology Today, 12 (10). pp. 282-388. ISSN 0169-4758

Denton, Helen and Roberts, Craig W. and Alexander, James and Thong, Kam-wah and Coombs, Graham H. (1996) Enzymes of energy metabolism in the bradyzoites and tachyzoites of Toxoplasma gondii. FEMS Microbiology Letters, 137 (1). pp. 103-108. ISSN 0378-1097

Roberts, C W and Ferguson, D J and Jebbari, H and Satoskar, A and Bluethmann, H and Alexander, J (1996) Different roles for interleukin-4 during the course of Toxoplasma gondii infection. Infection and Immunity, 64 (3). pp. 897-904. ISSN 0019-9567

Alexander, J and Jebbari, H and Bluethmann, H and Satoskar, A and Roberts, C W; Gross, Uwe, ed. (1996) Immunological control of Toxoplasma gondii and appropriate vaccine design. In: Toxoplasma gondii. Current Topics in Microbiology and Immunology . Springer, pp. 183-195. ISBN 9783642510168

Walker, W and Roberts, C W and Brewer, J M and Alexander, J (1995) Antibody responses to Toxoplasma gondii antigen in human peripheral blood lymphocyte-reconstituted severe-combined immunodeficient mice reproduce the immunological status of the lymphocyte donor. European Journal of Immunology, 25 (5). pp. 1426-1430. ISSN 0014-2980

Brewer, J M and Roberts, C W and Stimson, W H and Alexander, J (1995) Accurate determination of adjuvant-associated protein or peptide by ninhydrin assay. Vaccine, 13 (15). pp. 1441-1444. ISSN 1873-2518

Roberts, C W and Brewer, J M and Alexander, J (1994) Congenital toxoplasmosis in the Balb/c mouse : prevention of vertical disease transmission and fetal death by vaccination. Vaccine, 12 (15). pp. 1389-1394. ISSN 1873-2518

Blackwell, J. M. and Roberts, C. W. and Roach, T. I. A. and Alexander, J. (1994) Influence of macrophage resistance gene Lsh/Ity/Bcg (candidate Nramp) on Toxoplasma gondii infection in mice. Clinical and Experimental Immunology, 97 (1). pp. 107-112. ISSN 0009-9104

Brewer, James and Roberts, Craig and O'Grady, J. E. and Smart, Christine and Alexander, James; (1994) Non-ionic surfactant vesicles as vaccine delivery systems. In: Biotechnology '94. The Institution of Chemical Engineers, Rugby, pp. 34-36. ISBN 9780852953358

Alexander, J. and Roberts, C. W. and Brewer, J. M.; Smith, Judith E., ed. (1993) Progress towards the development of a vaccine against congenital toxoplasmosis : identification of protective antigens and the selection of appropriate adjuvants. In: Toxoplasmosis. Nato ASI Subseries H:, H78 . Springer-Verlag, Berlin, pp. 217-229. ISBN 9783642785610

HUNTER, C A and ROBERTS, C W and ALEXANDER, J (1992) Kinetics of cytokine messenger-rna production in the brains of mice with progressive toxoplasmic encephalitis. European Journal of Immunology, 22 (9). pp. 2317-2322. ISSN 0014-2980

Roberts, C W and Alexander, J and Roberts, Craig (1992) Studies on a murine model of congenital toxoplasmosis : vertical disease transmission only occurs in BALB/c mice infected for the first time during pregnancy. Parasitology, 104 (1). pp. 19-23. ISSN 0031-1820