The role of Interleukin-10 in susceptibility of BALB/c mice to infection with Leishmania mexicana and Leishmania amazonensis
Padigel, U.M. and Alexander, J. and Farrell, J.P. (2003) The role of Interleukin-10 in susceptibility of BALB/c mice to infection with Leishmania mexicana and Leishmania amazonensis. Journal of Immunology, 171. pp. 3705-3710. ISSN 0022-1767
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Recent studies have demonstrated the critical role of IL-10 in susceptibility to cutaneous and visceral leishmaniasis caused by Leishmania major and Leishmania donovani, respectively. To determine whether IL-10 also plays a similar role in the susceptibility and pathogenesis of cutaneous leishmaniasis caused by the New World species, L. mexicana and L. amazonensis, we analyzed their course of infection in IL-10-deficient BALB/c mice and their wild-type counterparts. Although IL-10-deficient mice infected with either L. mexicana or L. amazonensis failed to control the lesion progression, we did observe consistently lower levels of infection in IL-10-/- mice compared with wild-type BALB/c mice. We also observed increased IFN-{gamma} and NO production and higher levels for IL-12p40 and IL-12R{beta}2 mRNA in cells from IL-10-/- mice compared with cells from BALB/c mice. The mRNA levels for IL-4, which increased significantly in both IL-10-/- and BALB/c mice, were comparable. When treated with anti-IL-4 mAb, IL-10-/- mice resolved the infection more effectively and had significantly fewer parasites in their lesions compared with similarly treated BALB/c mice. These findings suggest that IL-10, although not the dominant mediator of susceptibility of BALB/c mice to infection with L. mexicana and L. amazonensis, does play a significant role in regulating the development of a protective Th1-type response. However, effective resolution of infection with these New World parasites requires neutralization of both IL-4 and IL-10.
| Author(s): | Padigel, U.M., Alexander, J. and Farrell, J.P. | Item type: | Article |
|---|---|
| ID code: | 5473 |
| Keywords: | Interleukin-10, infection, disease, immunology, Leishmania mexicana, Leishmania amazonensis, Pharmacy and materia medica, Physiology, Medicine(all) |
| Subjects: | Medicine > Pharmacy and materia medica Science > Physiology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Depositing user: | Strathprints Administrator |
| Date deposited: | 27 Feb 2008 |
| Last modified: | 12 Jul 2019 02:38 |
| URI: | https://strathprints.strath.ac.uk/id/eprint/5473 |
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