Picture of DNA strand

Pioneering chemical biology & medicinal chemistry through Open Access research...

Strathprints makes available scholarly Open Access content by researchers in the Department of Pure & Applied Chemistry, based within the Faculty of Science.

Research here spans a wide range of topics from analytical chemistry to materials science, and from biological chemistry to theoretical chemistry. The specific work in chemical biology and medicinal chemistry, as an example, encompasses pioneering techniques in synthesis, bioinformatics, nucleic acid chemistry, amino acid chemistry, heterocyclic chemistry, biophysical chemistry and NMR spectroscopy.

Explore the Open Access research of the Department of Pure & Applied Chemistry. Or explore all of Strathclyde's Open Access research...

T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection : is this paradigm still relevant?

Alexander, J. and Brombacher, F. (2012) T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection : is this paradigm still relevant? Frontiers in Immunology, 3 (APR).

[img] PDF (T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection)
AlexanderBrombacher2012.pdf
Final Published Version
License: Creative Commons Attribution-NonCommercial 4.0 logo

Download (755kB)

    Abstract

    Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4 T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively. However, the generation of IL-4mice in the 1990s questioned the paramount role of thisTh2 archetypal cytokine in the non-healing response to Leishmania infection. The more recent characterization of CD4 T cell regulatory populations and further effector CD4 T helper populations, Th17, Th9, and T follicular (f)h cells as well as the acknowledged plasticity in T helper cell function has further added to the complexity of host pathogen interactions.These interactions are complicated by the multiplicity of cells that respond to CD4 T cell subset signatory cytokines, as well as the diversity of Leishmania species that are often subject to significantly different immuneregulatory controls. In this article we review current knowledge with regard to the role of CD4 T cells and their products during Leishmania infection. In particular we update on our studies using conditional IL-4Rα gene-deficient mice that have allowed dissection of the cell interplay dictating the disease outcomes of the major Leishmania species infecting humans.