Ocular toxoplasmosis : in the storm of the eye

Jones, L.A. and Alexander, J. and Roberts, C.W. (2006) Ocular toxoplasmosis : in the storm of the eye. Parasite Immunology, 28 (12). pp. 635-642. ISSN 0141-9838

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Abstract

Ocular toxoplasmosis (OT) can occur in the children of mothers infected with Toxoplasma gondii during pregnancy. It is not limited to the congenitally infected, but can also occur following adult-acquired infection or as a result of disease reactivation in immune-compromised and pregnant individuals. Many aspects of immune privilege in the eye, including constitutive TGF-β expression and reduced MHC class 1 expression, would appear at first to favour parasite survival. Conversely, many of the mechanisms that control parasite multiplication in other anatomical sites, such as nitric oxide expression, IFN-γ and TNF-α, are known to disrupt immune privilege and are associated with ocular damage. Taking into account the opposing needs of limiting parasite multiplication and minimizing tissue destruction we review the pathogenesis of OT in the murine model.

Creators(s): Jones, L.A., Alexander, J. and Roberts, C.W. ORCID logoORCID: https://orcid.org/0000-0002-0653-835X;
Item type:Article
ID code:7577
Keywords:immune privilege, immunopathology, ocular toxoplasmosis, pharmacology, toxoplasma, Pharmacy and materia medica, Immunology, Parasitology
Subjects:Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Strathprints Administrator
Date deposited:30 Mar 2009 15:17
Last modified:20 Jan 2021 17:28
URI:https://strathprints.strath.ac.uk/id/eprint/7577
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