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Rapid cell mapping using nanoparticles and SERRS

Stokes, Robert J. and McKenzie, Fiona and McFarlane, Emma and Ricketts, Alastair and Tetley, L. and Faulds, Karen and Alexander, J. and Graham, Duncan (2009) Rapid cell mapping using nanoparticles and SERRS. Analyst, 134 (1). pp. 170-175. ISSN 0003-2654

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Abstract

Bone marrow-derived immune cells (macrophages) treated with gold and silver nanoparticles before fixation and dye staining have been analysed by multiple wavelength line scanning surface enhanced resonance Raman scattering (SERRS) mapping. The method yields high selectivity and sensitivity within short analysis times, identifying nanoparticle aggregates in secondary lysosomes. Using routine cell stains, the output from fluorescence, Raman and SERRS is quantified at four wavelengths of excitation, demonstrating the potential at longer biologically compatible wavelengths of using nanoparticles with cell stains for superior cell mapping.