The role of IL-4R alpha signalling during toxoplasma gondii infection

Mokgethi, T. and Nickdel, M.B. and Henriquez, F.L. and Roberts, F. and Brombacher, F. and Roberts, Craig and Alexander, J. (2008) The role of IL-4R alpha signalling during toxoplasma gondii infection. Immunology, 125 (s1). p. 110. OP 105. ISSN 0019-2805

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Official URL: https://doi.org/10.1111/j.1365-2567.2008.02974.x

Abstract

The protective immune response against Toxoplasma gondii is widely recognised as being type-1 mediated. Nevertheless, the overproduction of type-1 cytokines can induce severe pathology. The extent to which Th2 cytokines can modulate the disease protective versus disease exacerbating effects of type-1 cytokines remains to be resolved. We have therefore, compared the disease induced by T. gondii cysts in IL-4)/), IL-4Ra)/), and wild-type BALB/c mice, a mouse strain normally resistant to this disease. Increased mortality and increased lung pathology were observed in the absence of IL-4 and signalling via IL-4Ra and splenocyte type 1 cytokine and NO production was increased during early infection (day 12). IL-4 can modulate type-1 inflammatory responses by counter-regulating the effects of IFN-c on CD4+ T cells and/or macrophages.

Author(s):	Mokgethi, T., Nickdel, M.B., Henriquez, F.L., Roberts, F., Brombacher, F., Roberts, Craig ORCID: https://orcid.org/0000-0002-0653-835X and Alexander, J.
Item type:	Article
ID code:	19304
Keywords:	IL-4R alpha signalling, toxoplasma gondii infection, Immunology, Biology, Pharmacy and materia medica, Immunology, Immunology and Allergy
Subjects:	Science > Microbiology > Immunology Science > Natural history > Biology Medicine > Pharmacy and materia medica
Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Centre for Biophotonics Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Immunology Faculty of Science > Mathematics and Statistics
Depositing user:	Strathprints Administrator
Date deposited:	18 May 2010 14:24
Last modified:	20 Aug 2019 01:25
URI:	https://strathprints.strath.ac.uk/id/eprint/19304
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