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The role of IL-4R alpha signalling during toxoplasma gondii infection

Mokgethi, T. and Nickdel, M.B. and Henriquez, F.L. and Roberts, F. and Brombacher, F. and Roberts, Craig and Alexander, J. (2008) The role of IL-4R alpha signalling during toxoplasma gondii infection. Immunology, 125 (s1). p. 110. ISSN 0019-2805

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Abstract

The protective immune response against Toxoplasma gondii is widely recognised as being type-1 mediated. Nevertheless, the overproduction of type-1 cytokines can induce severe pathology. The extent to which Th2 cytokines can modulate the disease protective versus disease exacerbating effects of type-1 cytokines remains to be resolved. We have therefore, compared the disease induced by T. gondii cysts in IL-4)/), IL-4Ra)/), and wild-type BALB/c mice, a mouse strain normally resistant to this disease. Increased mortality and increased lung pathology were observed in the absence of IL-4 and signalling via IL-4Ra and splenocyte type 1 cytokine and NO production was increased during early infection (day 12). IL-4 can modulate type-1 inflammatory responses by counter-regulating the effects of IFN-c on CD4+ T cells and/or macrophages.

Item type: Article
ID code: 19304
Keywords: IL-4R alpha signalling, toxoplasma gondii infection, Immunology, Biology, Pharmacy and materia medica, Immunology, Immunology and Allergy
Subjects: Science > Microbiology > Immunology
Science > Natural history > Biology
Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Centre for Biophotonics
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Immunology
Faculty of Science > Mathematics and Statistics
Depositing user: Strathprints Administrator
Date deposited: 18 May 2010 14:24
Last modified: 21 May 2019 00:32
URI: https://strathprints.strath.ac.uk/id/eprint/19304
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