The role of IL-4R alpha signalling during toxoplasma gondii infection

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Mokgethi, T. and Nickdel, M.B. and Henriquez, F.L. and Roberts, F. and Brombacher, F. and Roberts, Craig and Alexander, J. (2008) The role of IL-4R alpha signalling during toxoplasma gondii infection. Immunology, 125 (s1). p. 110. OP 105. ISSN 0019-2805 (https://doi.org/10.1111/j.1365-2567.2008.02974.x)

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Abstract

The protective immune response against Toxoplasma gondii is widely recognised as being type-1 mediated. Nevertheless, the overproduction of type-1 cytokines can induce severe pathology. The extent to which Th2 cytokines can modulate the disease protective versus disease exacerbating effects of type-1 cytokines remains to be resolved. We have therefore, compared the disease induced by T. gondii cysts in IL-4)/), IL-4Ra)/), and wild-type BALB/c mice, a mouse strain normally resistant to this disease. Increased mortality and increased lung pathology were observed in the absence of IL-4 and signalling via IL-4Ra and splenocyte type 1 cytokine and NO production was increased during early infection (day 12). IL-4 can modulate type-1 inflammatory responses by counter-regulating the effects of IFN-c on CD4+ T cells and/or macrophages.

ORCID iDs

Mokgethi, T., Nickdel, M.B., Henriquez, F.L., Roberts, F., Brombacher, F., Roberts, Craig ORCID logoORCID: https://orcid.org/0000-0002-0653-835X and Alexander, J.;
CORE (COnnecting REpositories)