Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice

Komai-Koma, M and Brombacher, F and Pushparaj, P N and Arendse, B and McSharry, C and Alexander, J and Chaudhuri, R and McKenzie, A N J and McInnes, I and Liew, F Y and Xu, D and Thompson, N.C (2012) Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice. Allergy, 67 (9). pp. 1118-1126.

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Abstract

The regulation and function of IgE in healthy individuals and in antigen-naïve animals is not well understood. IL-33 administration increases serum IgE in mice with unknown mechanism. We tested the hypothesis that IL-33 provides an antigen-independent stimulus for IgE production and mast cell degranulation.

Author(s):Komai-Koma, M, Brombacher, F, Pushparaj, P N, Arendse, B, McSharry, C, Alexander, J, Chaudhuri, R, McKenzie, A N J, McInnes, I, Liew, F Y, Xu, D and Thompson, N.C
Item type:Article
ID code:47932
Notes:© 2012 John Wiley & Sons A/S.
Keywords:animals, cell degranulation, anaphylaxis, interleukins, mice, mice, nude, mice, inbred BALB C, immunoglobulin E, interleukin-4, mice, inbred C57BL, histamine release, flow cytometry, mast cells, Pharmacy and materia medica, Pharmacology (medical)
Subjects:Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:08 May 2014 11:57
Last modified:05 Jul 2019 03:41
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URI:https://strathprints.strath.ac.uk/id/eprint/47932
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