Interleukin-18 enhances a Th2 biased response and susceptibility to leishmania mexicana in BALB/c mice
Alexander, J. and Bryson, K.J. and Wei, X. (2008) Interleukin-18 enhances a Th2 biased response and susceptibility to leishmania mexicana in BALB/c mice. Microbes and Infection, 10 (7). pp. 834-839. ISSN 1286-4579
Full text not available in this repository.Request a copy from the Strathclyde authorAbstract
Interleukin-18 deficient mice on a BALB/c background display increased resistance to cutaneous infection with Leishmania mexicana, with reduced lesion progression and reduced parasite burdens compared with wild-type mice. Infected IL-18−/− mice had lower antigen specific IgG1 levels and total IgE levels and conversely higher antigen specific IgG2a levels than similarly infected wild-type mice. Splenocytes isolated from infected IL-18−/− mice produced significantly lower levels of antigen induced IL-4 and higher levels of IFN-γ than wild-type animals. Consequently IL-18 during L. mexicana infection of BALB/c mice promotes a Th2 biased response and thereby has a disease exacerbating role.
Creators(s): | Alexander, J., Bryson, K.J. and Wei, X.; | Item type: | Article |
---|---|
ID code: | 7580 |
Keywords: | interleukin-18, leishmania mexicana, Th2, microbes, infection, pharmacology, medicine, Pharmacy and materia medica, Infectious Diseases, Immunology, Microbiology |
Subjects: | Medicine > Pharmacy and materia medica |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
Depositing user: | Strathprints Administrator |
Date deposited: | 15 Apr 2009 11:00 |
Last modified: | 20 Jan 2021 17:38 |
URI: | https://strathprints.strath.ac.uk/id/eprint/7580 |
Export data: |