Interleukin-18 enhances a Th2 biased response and susceptibility to leishmania mexicana in BALB/c mice

Alexander, J. and Bryson, K.J. and Wei, X. (2008) Interleukin-18 enhances a Th2 biased response and susceptibility to leishmania mexicana in BALB/c mice. Microbes and Infection, 10 (7). pp. 834-839. ISSN 1286-4579

Abstract

Interleukin-18 deficient mice on a BALB/c background display increased resistance to cutaneous infection with Leishmania mexicana, with reduced lesion progression and reduced parasite burdens compared with wild-type mice. Infected IL-18−/− mice had lower antigen specific IgG1 levels and total IgE levels and conversely higher antigen specific IgG2a levels than similarly infected wild-type mice. Splenocytes isolated from infected IL-18−/− mice produced significantly lower levels of antigen induced IL-4 and higher levels of IFN-γ than wild-type animals. Consequently IL-18 during L. mexicana infection of BALB/c mice promotes a Th2 biased response and thereby has a disease exacerbating role.

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  Item type:	Article
  ID code:	7580
  Dates:	Date Event 2008 Published
  Keywords:	interleukin-18, leishmania mexicana, Th2, microbes, infection, pharmacology, medicine, Pharmacy and materia medica, Infectious Diseases, Immunology, Microbiology
  Subjects:	Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Strathprints Administrator
  Date deposited:	15 Apr 2009 11:00
  Last modified:	25 Jun 2021 02:55
  URI:	https://strathprints.strath.ac.uk/id/eprint/7580