Interleukin-18 enhances a Th2 biased response and susceptibility to leishmania mexicana in BALB/c mice

Alexander, J. and Bryson, K.J. and Wei, X. (2008) Interleukin-18 enhances a Th2 biased response and susceptibility to leishmania mexicana in BALB/c mice. Microbes and Infection, 10 (7). pp. 834-839. ISSN 1286-4579

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Abstract

Interleukin-18 deficient mice on a BALB/c background display increased resistance to cutaneous infection with Leishmania mexicana, with reduced lesion progression and reduced parasite burdens compared with wild-type mice. Infected IL-18−/− mice had lower antigen specific IgG1 levels and total IgE levels and conversely higher antigen specific IgG2a levels than similarly infected wild-type mice. Splenocytes isolated from infected IL-18−/− mice produced significantly lower levels of antigen induced IL-4 and higher levels of IFN-γ than wild-type animals. Consequently IL-18 during L. mexicana infection of BALB/c mice promotes a Th2 biased response and thereby has a disease exacerbating role.

Author(s):Alexander, J., Bryson, K.J. and Wei, X.
Item type:Article
ID code:7580
Keywords:interleukin-18, leishmania mexicana, Th2, microbes, infection, pharmacology, medicine, Pharmacy and materia medica, Infectious Diseases, Immunology, Microbiology
Subjects:Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Strathprints Administrator
Date deposited:15 Apr 2009 11:00
Last modified:05 Jul 2019 02:57
URI:https://strathprints.strath.ac.uk/id/eprint/7580
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