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Number of items: 78.

Article

Faure, N. E. and Halling, P. J. and Wimperis, S. (2014) A solid-state NMR study of the immobilization of alpha-chymotrypsin on mesoporous silica. Journal of Physical Chemistry C, 118 (2). pp. 1042-1048.

Gillespie, Cheska and Kennedy, Alan R. and Edwards, Darren and Dowden, Lee and Daublain, Pierre and Halling, Peter (2013) Detailed study of precipitation of a poorly water soluble test compound using methodologies as in activity and solubility screening - mixing and automation effects. Combinatorial Chemistry and High Throughput Screening, 16 (8). pp. 636-643. ISSN 1386-2073

Bayne, Lauren and Ulijn, Rein and Halling, Peter (2013) Effect of pore size on the performance of immobilised enzymes. Chemical Society Reviews, 42 (23). pp. 9000-9010. ISSN 0306-0012

Roy, Sangita and Javid, Nadeem and Sefcik, Jan and Halling, Peter J. and Ulijn, Rein V. (2012) Salt-induced control of supramolecular order in biocatalytic hydrogelation. Langmuir, 28 (48). pp. 16664-16670. ISSN 0743-7463

Roy, Sangita and Javid, Nadeem and Frederix, Pim and Lamprou, Dimitrios and Urquhart, Andrew and Hunt, Neil and Halling, Peter and Ulijn, Rein (2012) Dramatic specific ion effect in supramolecular hydrogels. Chemistry - A European Journal, 18 (37). pp. 11723-11731.

Braiuca, Paolo and Halling, Peter and Khaliullin, I. and Švedas, V. and Knapic, L. and Fermeglia, M. and Gardossi, L. (2012) BESSICC, a COSMO-RS based tool for in silico solvent screening of biocatalysed reactions. Biotechnology and Bioengineering, 109 (7). pp. 1864-1868. ISSN 0006-3592

Alissandratos, Apostolos and Halling, Peter (2012) Enzymatic acylation of starch. Bioresource Technology. (In Press)

Solanki, Kusum and Halling, Peter J. and Gupta, Munishwar N. (2012) Examining structure-activity correlations of some high activity enzyme preparations for low water media. Bioresource Technology, 115 (July). pp. 147-151.

Lousa, Diana and Cianci, M. and Helliwell, J. and Halling, Peter and Baptista, A and Soares, Claudio (2012) Interaction of counterions with subtilisin in acetonitrile : insights from molecular dynamics simulations. Journal of Physical Chemistry B, 116 (20). 5838–5848. ISSN 1520-6106

Gerdova, Anna and Kelly, Sharon M. and Halling, Peter (2011) Experimental test of absorption flattening correction for circular dichroism of particle suspensions. Chirality, 23 (7). pp. 574-579. ISSN 0899-0042

Gillespie, Cheska and Halling, Peter and Edwards, Darren (2011) Monitoring of particle growth at a low concentration of a poorly water soluble drug using the NanoSight LM20. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 384 (1-3). pp. 233-239. ISSN 0927-7757

Alissandratos, Apostolos and Baudendistel, Nina and Hauer, Bernhard and Baldenius, Kai and Flitsch, Sabine and Halling, Peter (2011) Biocompatible functionalisation of starch. Chemical Communications, 47 (2). pp. 683-685. ISSN 1359-7345

Alissandratos, Apostolos and Baudendistel, Nina and Flitsch, Sabine L. and Hauer, Bernhard and Halling, Peter J. (2010) Lipase-catalysed acylation of starch and determination of the degree of substitution by methanolysis and GC. BMC Biotechnology, 10. -.

Apweiler, Rolf and Armstrong, Richard and Bairoch, Amos and Cornish-Bowden, Athel and Halling, Peter J. and Hofmeyr, Jan-Hendrik S. and Kettner, Carsten and Leyh, Thomas S. and Rohwer, Johann and Schomburg, Dietmar and Steinbeck, Christoph and Tipton, Keith (2010) A large-scale protein-function database. Nature Chemical Biology, 6 (11). p. 785. ISSN 1552-4450

Halling, P.J. and Gardossi, L. (2010) Guidelines for reporting of biocatalytic reactions. Trends in Biotechnology, 28 (4). pp. 171-180. ISSN 0167-7799

Yang, Z. and Halling, P.J. (2010) Hofmeister effects on activity and stability of alkaline phosphatase. BBA - Biomembranes, 1804 (4). pp. 821-828. ISSN 0005-2736

Cianci, Michele and Tomaszewski, Bartlomiej and Helliwell, John R. and Halling, P.J. (2010) Crystallographic analysis of counterion effects on subtilisin enzymatic action in acetonitrile. Journal of the American Chemical Society, 132 (7). pp. 2293-2300. ISSN 0002-7863

Ganesan, A. and Moore, B.D. and Kelly, S.M. and Price, N.C. and Rolinski, O.J. and Birch, D.J.S. and Dunkin, I.R. and Halling, P.J. (2009) Optical spectroscopic methods for probing the conformational stability of immobilised enzymes. ChemPhysChem, 10 (9-10). pp. 1492-1499. ISSN 1439-4235

Halling, P.J. (2009) Estimation of flattening coefficient for absorption and circular dichroism using simulation. Analytical Biochemistry, 387 (1). pp. 76-81. ISSN 0003-2697

Deere, J. and De Oliveira, R.F. and Tomaszewski, B. and Millar, S. and Lalaouni, A. and Solares, Laura F. and Flitsch, Sabine L. and Halling, P.J. (2008) Kinetics of enzyme attack on substrates covalently attached to solid surfaces : influence of spacer chain length, immobilised substrate surface concentration and surface charge. Langmuir, 24 (20). pp. 11762-11769. ISSN 0743-7463

Halling, P.J. and Deere, J. and Maltman, B.A. and Flitsch, S.L. and McConnell, G. and Lalaouni, A. (2007) Real time imaging of protease action on substrates covalently immobilised to polymer supports. Advanced Synthesis and Catalysis, 349 (8-9). pp. 1321-1326. ISSN 1615-4150

Halling, P.J. and Ganesan, A. and Price, N.C. and Kelly, S.M. and Petry, I. and Moore, B.D. (2006) Circular dichroism studies of subtilisin carlsberg immobilised on micron sized silica particles. BBA - Biochimica et Biophysica Acta, 1764 (6). pp. 1119-1125.

Halling, P.J. and Braiuca, P. and Gardossi, L. and Pricl, S. and Fermeglia, M. (2006) In silico prediction of medium effects on esterification equilibrium using the COSMO-RS method. Biotechnology Progress, 22 (4). pp. 1146-1152. ISSN 8756-7938

Castllio, Betsaida and Bansal, Vibha and Ganesan, Ashok and Halling, P.J. and Secundo, Francesco and Ferrer, Amaris (2006) On the activity loss of hydrolases in organic solvents : II. a mechanistic study of subtilisin Carlsberg. BMC Biotechnology, 6 (51). ISSN 14726750

Kreiner, M. and Fernandes, J.F.A. and O'Farrell, N. and Halling, P.J. and Parker, M.C. (2005) Stability of protein-coated microcrystals in organic solvents. Journal of Molecular Catalysis B: Enzymatic, 33 (3-6). pp. 65-72. ISSN 1381-1177

Fernandes, J.F.A. and McAlpine, M. and Halling, P.J. (2005) Operational stability of subtilisin CLECs in organic solvents in repeated batch and in continuous operation. Biochemical Engineering Journal, 24 (1). pp. 11-15. ISSN 1369-703X

Flores, M.V. and Engasser, J.M. and Halling, P.J. (2005) Dissolution kinetics of crystalline alpha-glucose in 2-methyl 2-butanol. Biochemical Engineering Journal, 22 (3). pp. 245-252. ISSN 1369-703X

Veum, L. and Kanerva, L.T. and Halling, P.J. and Maschmeyer, T. and Hanefeld, U. (2005) Optimisation of the enantioselective synthesis of cyanohydrin esters. Advanced Synthesis and Catalysis, 347 (7-8). pp. 1015-1021. ISSN 1615-4150

Halling, P.J. and Ulijn, R.V. and Flitsch, S.L. (2005) Understanding enzyme action on immobilised substrates. Current Opinion in Biotechnology, 16 (4). pp. 385-392. ISSN 0958-1669

Sarmento, A.C. and Oliveira, C.S. and Pires, E.M. and Halling, P.J. and Barros, M.T. (2004) Evaluation of cardosin A as a proteolytic probe in the presence of organic solvents. Journal of Molecular Catalysis B: Enzymatic, 31 (4-6). pp. 137-141. ISSN 1381-1177

Halling, P.J. (2004) What can we learn by studying enzymes in non-aqueous media? Philosophical Transactions B: Biological Sciences, 359 (1448). pp. 1287-1297. ISSN 0962-8436

Theppakorn, T. and Kanasawud, P. and Halling, P.J. (2004) Activity of immobilized papain dehydrated by n-propanol in low- water media. Biotechnology Letters, 26 (2). pp. 133-136. ISSN 0141-5492

Ulijn, R.V. and Halling, P.J. (2004) Solid-to-solid biocatalysis: thermodynamic feasibility and energy efficiency. Green Chemistry, 6 (9). pp. 488-496. ISSN 1463-9262

Fontes, N. and Halling, P.J. and Barreiros, S. (2003) Control of enzyme ionization state in supercritical ethane by sodium/proton solid-state acid-base buffers. Enzyme and Microbial Technology, 33 (7). pp. 938-941. ISSN 0141-0229

Bosman, A.Y. and Ulijn, R.V. and McConnell, G. and Girkin, J.M. and Halling, P.J. and Flitsch, S.L. (2003) Using two photon microscopy to quantify enzymatic reaction rates on polymer beads. Chemical Communications (London), 2003 (23). pp. 2790-2791. ISSN 0009-241X

Ulijn, R.V. and De Martin, L. and Gardossi, L. and Halling, P.J. (2003) Biocatalysis in reaction mixtures with undissolved solid substrates and products. Current Organic Chemistry, 7 (13). pp. 1333-1346. ISSN 1385-2728

Halling, Peter J. and Wilson, Stephen K. and Jacobs, Ralf and McKee, Sean and Coles, Christopher W. (2003) Modeling the kinetics of enzymic reactions in mainly solid reaction mixtures. Biotechnology Progress, 19 (4). pp. 1228-1237. ISSN 8756-7938

Fontes, N. and Harper, N. and Halling, P.J. and Barreiros, S. (2003) Salt hydrates for in situ water activity control have acid-base effects on enzymes in nonaqueous media. Biotechnology and Bioengineering, 82 (7). pp. 802-808. ISSN 0006-3592

Theppakorn, T. and Kanasawud, P. and Halling, P.J. (2003) Effect of solid-state buffers on the catalytic activity of papain in low water media. Enzyme and Microbial Technology, 32 (7). pp. 828-836. ISSN 0141-0229

Ulijn, R.V. and Brazendale, I. and Margetts, G. and Flitsch, S.L. and McConnell, G. and Girkin, J.M. and Halling, P.J. (2003) Biocatalysis in reaction mictures with undissolved solid substrates and products. ChemInform, 35 (26). pp. 1339-1346. ISSN 0931-7597

Sarmento, A.C. and Oliveira, C. and Pires, E. and Halling, P.J. and Barros, M.T. (2003) Cardosin A as a model aspartic proteinase for the study of organic solvent effects. An overview on catalytic and structural aspects. Journal of Molecular Catalysis B: Enzymatic, 21 (1-2). pp. 19-23. ISSN 1381-1177

Ulijn, R.V. and Brazendale, I. and Margetts, G. and Flitsch, S.L. and McConnell, G. and Girkin, J.M. and Halling, P.J. (2003) Two photon microscopy to spatially resolve and quantify fluorophores in single bead chemistry. Journal of Combinatorial Chemistry, 5 (3). pp. 215-217. ISSN 1520-4766

Ulijn, R.V. and Bisek, N. and Halling, P.J. and Flitsch, S.L. (2003) Understanding protease catalysed solid phase peptide synthesis. Organic and Biomolecular Chemistry, 1 (8). pp. 1277-1281. ISSN 1477-0520

Ulijn, R.V. and De Martin, L. and Gardossi, L. and Janssen, A.E.M. and Moore, B.D. and Halling, P.J. (2002) Solvent selection for solid-to-solid synthesis. Biotechnology and Bioengineering, 80 (5). pp. 509-515. ISSN 0006-3592

Ulijn, R.V. and De Martin, L. and Halling, P.J. and Moore, B.D. and Janssen, A.E.M. (2002) Enzymatic synthesis of beta-lactam antibiotics via direct condensation. Journal of Biotechnology, 99 (3). pp. 215-222. ISSN 0168-1656

Ulijn, R.V. and Janssen, A.E.M. and Moore, B.D. and Halling, P.J. and Kelly, S.M. and Price, N.C. (2002) Reversible acetonitrile-induced inactivation/activation of thermolysin. Chembiochem, 3 (11). pp. 1112-1116. ISSN 1439-4227

Fernandes, J.F.A. and Halling, P.J. (2002) Operational stability of high initial activity protease catalysts in organic solvents. Biotechnology Progress, 18 (6). pp. 1455-1457. ISSN 8756-7938

Ulijn, R.V. and Baragana, B. and Halling, P.J. and Flitsch, S.L. (2002) Protease-catalyzed peptide synthesis on solid support. Journal of the American Chemical Society, 124 (37). pp. 10988-10989. ISSN 0002-7863

Tsavas, P. and Polydorou, S. and Faflia, I. and Voutsas, E.C. and Tassios, D. and Flores, M.V. and Naraghi, K. and Halling, P.J. and Chamouleau, F. and Ghoul, M. and Engasser, J.M. and Ferrer, M. and Plou, F.J. (2002) Solubility of glucose in mixtures containing 2-methyl-2- butanol, dimethyl sulfoxide, acids, esters, and water. Journal of Chemical and Engineering Data, 47 (4). pp. 807-810. ISSN 0021-9568

Flores, M.V. and Halling, P.J. (2002) Full model for reversible kinetics of lipase-catalyzed sugar- ester synthesis in 2-methyl 2-butanol. Biotechnology and Bioengineering, 78 (7). pp. 794-800. ISSN 0006-3592

Flores, M.V. and Naraghi, K. and Engasser, J.M. and Halling, P.J. (2002) Influence of glucose solubility and dissolution rate on the kinetics of lipase catalyzed synthesis of glucose laurate in 2- methyl 2-butanol. Biotechnology and Bioengineering, 78 (7). pp. 814-820. ISSN 0006-3592

Rees, D.G. and Gerashchenko, ll. and Kudryashova, E.V. and Mozhaev, V.V. and Halling, P.J. (2002) Chemical modification causes similar change in dependence on water activity of chymotrypsin hydration and catalysis in hexane. Biocatalysis and Biotransformation, 20 (3). pp. 161-166. ISSN 1024-2422

Pedersen, N.R. and Halling, P.J. and Pedersen, L.H. and Wimmer, R. and Matthiesen, R. and Veltman, O.R. (2002) Efficient transesterification of sucrose catalysed by the metalloprotease thermolysin in dimethylsulfoxide. FEBS Letters, 519 (1-3). pp. 181-184. ISSN 0014-5793

Tsavas, P. and Polydorou, S. and Voutsas, E.C. and Magoulas, K.G. and Naraghi, K. and Halling, P.J. (2002) Sucrose solubility in mixtures of water, alcohol, ester, and acid. Journal of Chemical and Engineering Data, 47 (3). pp. 513-517. ISSN 0021-9568

Fontes, N. and Partridge, J. and Halling, P.J. and Barreiros, S. (2002) Zeolite molecular sieves have dramatic acid-base effects on enzymes in nonaqueous media. Biotechnology and Bioengineering, 77 (3). pp. 296-305. ISSN 0006-3592

Ulijn, R.V. and Moore, B.D. and Janssen, A.E.M. and Halling, P.J. (2002) A single aqueous reference equilibrium constant for amide synthesis-hydrolysis. Journal of the Chemical Society, Perkin Transactions 2, 2002 (5). pp. 1024-1028. ISSN 1472-779X

Harper, N. and Dolman, M. and Moore, B.D. and Halling, P.J. (2001) Effect of water activity on the rate profile of subtilisin Carlsberg in toluene in the presence of an organo-soluble acid- base buffer. Enzyme and Microbial Technology, 29 (6-7). pp. 413-416. ISSN 0141-0229

van den Heuvel, R.H.H. and Partridge, J. and Laane, C. and Halling, P.J. and van Berkel, W.J.H. (2001) Tuning of the product spectrum of vanillyl-alcohol oxidase by medium engineering. FEBS Letters, 503 (2-3). pp. 213-216. ISSN 0014-5793

Flores, M.V. and Voutsas, E.C. and Spiliotis, N. and Eccleston, G.M. and Bell, G. and Tassios, D.P. and Halling, P.J. (2001) Critical micelle concentrations of nonionic surfactants in organic solvents: Approximate prediction with UNIFAC. Journal of Colloid and Interface Science, 240 (1). pp. 277-283. ISSN 0021-9797

Ulijn, R.V. and Janssen, A.E.M. and Moore, B.D. and Halling, P.J. (2001) Predicting when precipitation-driven synthesis is feasible: application to biocatalysis. Chemistry - A European Journal, 7 (10). pp. 2089-2098. ISSN 0947-6539

Voutsas, E.C. and Flores, M.V. and Spiliotis, N. and Bell, G. and Halling, P.J. and Tassios, D.P. (2001) Prediction of critical micelle concentrations of nonionic surfactants in aqueous and nonaqueous solvents with UNIFAC. Industrial and Engineering Chemistry Research, 40 (10). pp. 2362-2366. ISSN 0888-5885

Fontes, N. and Almeida, M.C. and Garcia, S. and Peres, C. and Partridge, J. and Halling, P.J. and Barreiros, S. (2001) Supercritical fluids are superior media for catalysis by cross- linked enzyme microcrystals of subtilisin Carlsberg. Biotechnology Progress, 17 (2). pp. 355-358. ISSN 8756-7938

Rees, D. Gareth and Halling, Peter J. (2001) Chemical modification probes accessibility to organic phase: proteins on surfaces are more exposed than in lyophilized powders - correction. Enzyme and Microbial Technology, 28 (2-3). pp. 282-292. ISSN 0141-0229

Erbeldinger, M. and Halling, P.J. and Ni, X.W. (2001) Scale-up of enzymatic solid-to-solid peptide synthesis and enzyme recovery. AIChE Journal, 47 (2). pp. 500-508. ISSN 0001-1541

Guisan, J.M. and Sabuquillo, P. and Fernandez-Lafuente, R. and Fernandez-Lorente, G. and Mateo, C. and Halling, P.J. and Kennedy, D. and Miyata, E. and Re, D. (2001) Preparation of new lipases derivatives with high activity- stability in anhydrous media: adsorption on hydrophobic supports plus hydrophilization with polyethylenimine. Journal of Molecular Catalysis B: Enzymatic, 11 (4-6). pp. 817-824. ISSN 1381-1177

Pirozzi, D. and Halling, P.J. (2001) Development of small-size tubular-flow continuous reactors for the analysis of operational stability of enzymes in low-water systems. Biotechnology and Bioengineering, 72 (2). pp. 244-248. ISSN 0006-3592

Erbeldinger, M. and Ni, X.W. and Halling, P.J. (2001) Kinetics of enzymatic solid-to-solid peptide synthesis: Synthesis of Z-aspartame and control of acid-base conditions by using inorganic salts. Biotechnology and Bioengineering, 72 (1). pp. 69-76. ISSN 0006-3592

Rees, D.Gareth and Halling, Peter J. (2000) Chemical modification probes accessibility to organic phase: proteins on surfaces are more exposed than in lyophilized powders. Enzyme and Microbial Technology, 27 (8). pp. 549-559. ISSN 0141-0229

Ulijn, R.V. and Erbeldinger, M. and Halling, P.J. (2000) Comparison of methods for thermolysin-catalyzed peptide synthesis including a novel more active catalyst. Biotechnology and Bioengineering, 69 (6). pp. 633-638. ISSN 0006-3592

Book

Vulfson, E.N. and Halling, P.J. and Holland, H.L. (2001) Methods in biotechnology: enzymes in nonaqueous solvents. Humana Press, NJ, USA. ISBN 089603-9293

Book Section

Halling, P.J. (2008) Biocatalysis with undissolved solid substrates and products. In: Organic Synthesis with Enzymes in Non-Aqueous Media. Wiley-VCH, pp. 279-287. ISBN 9783527318469

Halling, P.J. (2002) Enzymic conversions in organic and other low-water media. In: Enzyme Catalysis in Organic Synthesis: A Comprehensive Handbook. Wiley-VCH, Weinheim, Germany, pp. 259-285. ISBN 03527-299491

Partridge, J. and Harper, N. and Moore, B.D. and Halling, P.J. (2001) Control of acid-base conditions in low-water media. In: Methods in Biotechnology: Enzymes in Nonaqueous Solvents. Methods in Biotechnology (15). Humana Press, NJ, USA, pp. 227-234. ISBN 0896039293

Erbeldinger, M. and Eichhorn, U. and Kuhl, P. and Halling, P.J. (2001) Enzymatic solid-to-solid peptide synthesis. In: Methods in Biotechnology: Enzymes in Nonaqueous Solvents. Methods in Biotechnology, 15 . Humana Press, NJ, USA, pp. 471-477. ISBN 089603-9293

Bell, G. and Halling, P.J. and May, L. and Moore, B.D. and Robb, D.A. and Ulijn, R. and Valivety, R.H. (2001) Methods for measurement and control of water in non-aqueous biocatalysis. In: Methods in Biotechnology: Enzymes in Nonaqueous Solvents. Humana Press, NJ, USA, pp. 105-126. ISBN 0896039293

Moore, B.D. and Partridge, J. and Halling, P.J. (2001) Very high activity biocatalysts for low water systems: Propanol rinsed enzyme preparations (PREPs). In: Methods in Biotechnology: Enzymes in Nonaqueous Solvents. Methods in Biotechnology, 15 . Humana Press, NJ, USA, pp. 97-104. ISBN 0896039293

Conference or Workshop Item

Yue, Hong and Halling, Peter and Yu, Hui (2013) Model development and optimal experimental design of a kinetically controlled synthesis system. In: International Symposium on Computer Applications in Biotechnology (CAB2013), 2013-12-16 - 2013-12-18, Mumbai.

Patent

Halling, Peter (2000) Rapid Dehydration of Proteins. .

This list was generated on Sat Nov 22 11:48:19 2014 GMT.