Picture water droplets

Developing mathematical theories of the physical world: Open Access research on fluid dynamics from Strathclyde

Strathprints makes available Open Access scholarly outputs by Strathclyde's Department of Mathematics & Statistics, where continuum mechanics and industrial mathematics is a specialism. Such research seeks to understand fluid dynamics, among many other related areas such as liquid crystals and droplet evaporation.

The Department of Mathematics & Statistics also demonstrates expertise in population modelling & epidemiology, stochastic analysis, applied analysis and scientific computing. Access world leading mathematical and statistical Open Access research!

Explore all Strathclyde Open Access research...

Model development and optimal experimental design of a kinetically controlled synthesis system

Yue, Hong and Halling, Peter and Yu, Hui (2013) Model development and optimal experimental design of a kinetically controlled synthesis system. In: International Symposium on Computer Applications in Biotechnology (CAB2013), 2013-12-16 - 2013-12-18.

Full text not available in this repository. Request a copy from the Strathclyde author


A mathematical model has been developed for an enzymatic process with kinetically controlled synthesis. Model reduction and detailed system analysis have been undertaken to examine the main properties of this enzyme reaction system. Optimal experimental design (OED) is developed to obtain the experimental conditions that will generate the most informative measurement data for parameter estimation. Both single-input and multiple-inputs optimisation strategies have been investigated to determine the best intensity levels of control inputs. The results demonstrate that parameter estimation quality can be improved through proper model-based experimental design.