Picture of DNA strand

Pioneering chemical biology & medicinal chemistry through Open Access research...

Strathprints makes available scholarly Open Access content by researchers in the Department of Pure & Applied Chemistry, based within the Faculty of Science.

Research here spans a wide range of topics from analytical chemistry to materials science, and from biological chemistry to theoretical chemistry. The specific work in chemical biology and medicinal chemistry, as an example, encompasses pioneering techniques in synthesis, bioinformatics, nucleic acid chemistry, amino acid chemistry, heterocyclic chemistry, biophysical chemistry and NMR spectroscopy.

Explore the Open Access research of the Department of Pure & Applied Chemistry. Or explore all of Strathclyde's Open Access research...

Optimal experimental design for an enzymatic biodiesel production system

Yu, Hui and Yue, Hong and Halling, Peter (2015) Optimal experimental design for an enzymatic biodiesel production system. In: 9th IFAC Symposium on Advanced Control of Chemical Processes - ADCHEM 2015, 2015-06-07 - 2015-06-10.

Text (Yu-etal-ADCHEM2015-optimal-experimental-design-enzymatic-biodiesel-production-system)
Accepted Author Manuscript

Download (410kB)| Preview


    Two optimal experimental design (OED) problems for an enzymatic biodiesel production system are investigated to improve parameter estimation quality. An orthogonalized sensitivity analysis method is firstly implemented to select important parameters. Next the design of measurement set and sampling strategy is developed in the form of two convex optimization problems which are solved by the interior-point algorithm and the Powell’s method, respectively. Simulation results demonstrate the function of OED in reducing parameter estimation errors. The biodiesel concentration is identified to be the most valuable state variable observation, and the parameter estimation accuracy can be improved through optimal sampling design.