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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

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A two-loop optimization strategy for multi-objective optimal experimental design

Yu, Hui and Yue, Hong and Halling, Peter (2016) A two-loop optimization strategy for multi-objective optimal experimental design. IFAC-PapersOnLine, 49 (7). pp. 803-808. ISSN 1474-6670

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Abstract

A new strategy of optimal experimental design (OED) is proposed for a kinetically controlled synthesis system by considering both observation design and input design. The observation design that combines sampling scheduling and measurement set selection is treated as a single optimization problem arranged in the inner loop, while the optimization of input intensity is calculated in the outer loop. This multi-objective dynamic optimization problem is solved via the integration of particle swarm algorithm (for the outer loop) and the interior-point method (for the inner loop). Numerical studies demonstrate the efficiency of this optimization strategy and show the effectiveness of this integrated OED in reducing parameter estimation uncertainties. In addition, process optimization of the case study enzyme reaction system is investigated with the aim to obtain maximum production rate by taking into account of the experimental cost.