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Alniss, Hasan Y H and Salvia, Marie-Virginie and Sadikov, Mykhailo and Golovchenko, Igor and Anthony, Nahoum Guillaume Hsuan and Khalaf, Abedawn and MacKay, Simon and Suckling, Colin and Parkinson, John (2014) Recognition of the DNA minor groove by thiazotropsin analogues. Chembiochem, 15 (13). 1978–1990. ISSN 1439-4227 (In Press)

Rzepecka, Justyna and Coates, Michelle and Saggar, Moninder and Al-Riyami, Lamyaa and Coltherd, Jennifer and Tay, Hwee Kee and Huggan, Judith and Janicova, Lucia and Khalaf, Abedawn and Siebeke, Ivonne and Suckling, Colin and Harnett, Margaret and Harnett, William (2014) Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties. International Journal for Parasitology, 44 (9). pp. 669-674. ISSN 0020-7519

Lang, Stuart and Khalaf, Abedawn I and Breen, David and Huggan, Judith and Clements, Carol and MacKay, Simon and Suckling, Colin (2014) Oligoamides of 2-amino-5-alkylthiazole 4-carboxylic acids : anti-trypanosomal compounds. Medicinal Chemistry Research, 23 (3). pp. 1170-1179.

Khalaf, Abedawn I and Huggan, Judith and Suckling, Colin J and Gibson, Colin L and Stewart, Kirsten and Giordani, Federica and Barrett, Michael P. and Wong, Pui Ee and Barrack, Keri L and Hunter, William N (2014) Structure based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1. Journal of Medicinal Chemistry. ISSN 0022-2623

Salvia, Marie-Virginie and Addison, Fiona and Alniss, Hasan Y H and Buurma, Niklaas J and Khalaf, Abedawn and MacKay, Simon and Anthony, Nahoum G and Suckling, Colin and Evstigneev, Maxim P and Santiago, Adrian Hernandez and Waigh, Roger and Parkinson, John (2013) Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove. Biophysical Chemistry, 179. pp. 1-11. ISSN 0301-4622

Al-Riyami, Lamyaa and Pineda, Miguel and Rzepecka, Justyna and Huggan, Judith and Khalaf, Abedawn and Suckling, Colin and Scott, Fraser and Rodgers, David and Harnett, Margaret and Harnett, William (2013) Designing anti-inflammatory drugs from parasitic worms : a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis. Journal of Medicinal Chemistry, 56. pp. 9982-10002. ISSN 0022-2623

Al-Riyami, Lamyaa and Pineda, Miguel and Rzepecka, Justyna and Huggan, Judith and Khalaf, Abedawn and Suckling, Colin and Scott, Fraser and Rodgers, David and Harnett, Margaret and Harnett, William (2013) Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis : Helminth-based synthetic compound protects against CIA. Journal of Medicinal Chemistry, n/a (n/a). n/a. ISSN 0022-2623 (In Press)

Khalaf, Abedawn and Bourdin, Claire and Breen, David and Donoghue, Gavin and Scott, Fraser and Suckling, Colin and MacMillan, Donna and Clements, Carol and Fox, Keith and Sekibo, Doreen (2012) Design, synthesis and antibacterial activity of minor groove binders: the role of non-cationic tail groups. European Journal of Medicinal Chemistry, 56. pp. 39-47. ISSN 0223-5234

Alniss, Hasan Y and Anthony, Nahoum Guillaume Husan and Khalaf, Abedawn and Mackay, Simon and Suckling, Colin and Waigh, Roger and Wheate, Nial and Parkinson, John (2012) Rationalising sequence selection by ligand assemblies in the DNA minor groove : the case for thiazotropsin A. Chemical Science, 3 (3). pp. 711-722. ISSN 2041-6520

Khalaf, Abedawn I and Anthony, Nahoum and Breen, David and Donoghue, Gavin and Mackay, Simon P and Scott, Fraser J and Suckling, Colin J (2011) Amide isosteres in structure-activity studies of antibacterial minor groove binders. European Journal of Medicinal Chemistry, 46 (11). pp. 5343-5355.

Al-Riyami, Lamyaa and Rzepecka, Justyna and Khalaf, Abedawn and Suckling, Colin and Harnett, M. and Harnett, William (2010) Small molecule analogues of an immunomodulatory helminth product provide a novel approach to dissecting macrophage signal transduction pathways : Poster abstract. Immunology, 131 (Supplement 1). p. 164. ISSN 0019-2805

Wittayanarakul, Kitiyaporn and Anthony, N.G. and Treesuwan, Witcha and Hannongbua, Supa and Alniss, Hasan and Khalaf, A.I. and Suckling, C.J. and Parkinson, J.A. and Mackay, Simon P. and , Royal Golden Jubilee Ph.D. Program (Funder) and , Thailand Research Fund (Funder) and , W.T. and EPSRC (Funder) and , Scottish Funding Council (Funder) (2010) Ranking ligand affinity for the DNA minor groove by experiment and simulation. Medicinal Chemistry Letters, 1 (8). pp. 376-680. ISSN 1948-5875

Kennedy, Alan and Khalaf, Abedawn I. and Suckling, Colin J. (2010) 2,2,2-Trifluoro-N-(isoquinolin-5-ylmethyl)acetamide. Acta Crystallographica Section E: Structure Reports, 66 (Pt 1). o135. ISSN 1600-5368

Khalaf, Abedawn I (2010) Photochemistry and free radical stabilisation of the captodative centre. Trends In Photochemistry And Photobiology, 12. pp. 7-15. ISSN 0972-4532

Khalaf, Abedawn I (2010) Photocyclization of Stilbenes and Stilbenoids. Trends In Photochemistry And Photobiology, 12. pp. 65-75. ISSN 0972-4532

Khalaf, A.I. and Badman, Clive E. and Ennis, Marcus P. and Horspool, William M. (2010) The influence of aryl-aryl interactions in the photochemistry of some 1,3-Diarylpropanes. Trends In Photochemistry And Photobiology, 12. ISSN 0972-4532

Treesuwan, Witcha and Wittayanarakul, Kitiyaporn and Anthony, Nahoum G. and Huchet, Guillaume and Alniss, Hasan and Hannongbua, Supa and Khalaf, Abedawn I. and Suckling, Colin J. and Parkinson, John A. and Mackay, Simon P. (2009) A detailed binding free energy study of 2 : 1 ligand–DNA complex formation by experiment and simulation. Physical Chemistry Chemical Physics, 11 (45). pp. 10682-10693. ISSN 1463-9076

Anthony, N.G. and Breen, D. and Donoghue, G. and Khalaf, A.I. and Mackay, S.P. and Parkinson, J.A. and Suckling, C.J. (2009) A new synthesis of alkene-containing minor-groove binders and essential hydrogen bonding in binding to DNA and in antibacterial activity. Organic and Biomolecular Chemistry, 7 (9). pp. 1843-1850. ISSN 1477-0520

Parkinson, J.A. and Khalaf, A.I. and Anthony, N.G. and Mackay, S.P. and Suckling, C.J. and Waigh, R.D. (2009) Comparison of DNA complex formation behaviour for two closely related lexitropsin analogues. Helvetica Chimica Acta, 92 (5). pp. 795-822. ISSN 0018-019X

Khalaf, Abedawn I. (2009) Minor groove binders: some recent research in drug development. Current Trends in Medicinal Chemistry, 6. pp. 53-63.

Anthony, Nahoum Guillaume Hsuan and Breen, D. and Clarke, Joanna and Donoghue, Gavin and Drummond, Allan J. and Ellis, Elizabeth and Gemmell, Curtis G. and Helesbeux, Jean-Jacques and Hunter, Iain. S. and Khalaf, Abedawn and MacKay, Simon and Parkinson, J.A. and Suckling, C.J. and Waigh, R.D. (2007) Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups. Journal of Medicinal Chemistry, 50 (24). pp. 6116-6125. ISSN 0022-2623

Suckling, C.J. and Murphy, J.A. and Khalaf, A.I. and Zhou, S. and Lizos, D.E. and Nguyen Van Nhien, A. and Yasumatsu, H. and McVie, A. and Young, L.C. and McCraw, C. and Waterman, P.G. and Morris, B.J. and Pratt, J.A. and Harvey, A. (2007) M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds. Bioorganic and Medicinal Chemistry Letters, 17 (9). pp. 2649-2655. ISSN 0960-894X

Kennedy, Alan and Khalaf, Abedawn I. and Suckling, Colin J. and Waigh, Roger D. (2006) 3-Nitro-1-(triisopropylsilyl)-1H-pyrrole. Acta Crystallographica Section E: Structure Reports, 62 (8). o3282-o3284. ISSN 1600-5368

Suckling, C.J. and Hampshire, Andrew J. and Khairallah, Hannah and Khalaf, A.I. and Ebrahimabadi, Abdolrasoul H. and Waigh, R.D. and Brown, Tom and Fox, Keith R. (2006) DNA sequence recognition by an imidazole-containing isopropyl thiazole polyamide (thiazotropsin b). Bioorganic and Medicinal Chemistry Letters, 16 (13). pp. 3469-3474.

Alvarez, R.G. and Kennedy, A.R. and Khalaf, A.I. and Suckling, C.J. and Waigh, R.D. (2005) 2-(1-Piperidinyl)-1,3-benzothiazole. Acta Crystallographica Section E: Structure Reports, 61. pp. 569-570. ISSN 1600-5368

Al-Hiari, Yusuf M. and Bennett, Stephen J. and Cox, Brian and Davies, Robert J. and Khalaf, Abedawn I. and Waigh, Roger D. and Worsley, Alan J. (2005) Steps towards a practical synthesis of macrocyclic bisbenzylisoquinolines. Journal of Heterocyclic Chemistry, 42 (4). pp. 647-659. ISSN 0022-152X

Khalaf, A.I. and Ebrahimabadi, A.H. and Drummond, A.J. and Anthony, N.G. and Mackay, S.P. and Suckling, C.J. and Waigh, R.D. (2004) Synthesis and antimicrobial activity of some netropsin analogues. Organic and Biomolecular Chemistry, 2 (21). pp. 3119-3127. ISSN 1477-0520

Kennedy, A.R. and Khalaf, A.I. and Suckling, C.J. and Waigh, R.D. (2004) Methyl 2-amino-5-iso­propyl-1,3-thia­zole-4-carboxyl­ate. Acta Crystallographica Section E: Structure Reports, 60 (9). pp. 1510-1512. ISSN 1600-5368

Anthony, N.G. and Johnston, B.F. and Khalaf, A.I. and Mackay, S.P. and Parkinson, J.A. and Suckling, C.J. and Waigh, R.D. (2004) Short Lexitropsin that Recognizes the DNA Minor Groove at 5'-ACTAGT-3': Understanding the Role of Isopropyl-thiazole. Journal of the American Chemical Society, 126 (36). pp. 11338-11349. ISSN 0002-7863

Kennedy, A.R. and Khalaf, A.I. and Suckling, C.J. and Waigh, R.D. (2004) Ethyl 2-amino-4-isopropyl-1,3-thiazole-5-carboxylate. Acta Crystallographica Section E: Structure Reports, 60 (8). pp. 1188-1190. ISSN 1600-5368

James, P.L. and Merkina, E.E. and Khalaf, A.I. and Suckling, C.J. and Waigh, R.D. and Brown, T. and Fox, K.R. (2004) DNA sequence recognition by an isopropyl substituted thiazole polyamide. Nucleic Acids Research, 32 (11). pp. 3410-3417. ISSN 0305-1048

Anthony, N.G. and Fox, K.R. and Johnston, B.F. and Khalaf, A.I. and Mackay, S.P. and McGroarty, I.S. and Parkinson, J.A. and Skellern, G.G. and Suckling, C.J. and Waigh, R.D. (2004) DNA binding of a short lexitropsin. Bioorganic and Medicinal Chemistry Letters, 14 (5). pp. 1353-1356. ISSN 0960-894X

Khalaf, A.I. and Waigh, R.D. and Drummond, A.J. and Pringle, B. and McGroarty, I. and Skellern, G.G. and Suckling, C.J. (2004) Distamycin Analogues with Enhanced Lipophilicity: Synthesis and Antimicrobial Activity. Journal of Medicinal Chemistry, 47 (8). pp. 2133-2156. ISSN 0022-2623

Kennedy, A.R. and Khalaf, A.I. and Suckling, C.J. and Waigh, R.D. (2003) Ethyl 5-oxo-2,5-dihydro-4-isoxazolecarboxylate hydroxylamine salt. Acta Crystallographica Section E: Structure Reports, 59 (9). pp. 1410-1412. ISSN 1600-5368

Kennedy, Alan and Khalaf, Abedawn and Suckling, Colin and Waigh, Roger (2001) Ethyl 2-aminooxazole-5-carboxylate. Acta Crystallographica Section E: Structure Reports, 57. o832-o833. ISSN 1600-5368

Khalaf, A.I. and Alvarez, R.G. and Suckling, C.J. and Waigh, R.D. (2000) Unexpected Dealkylation During Nucleophilic Substitution: Synthesis of 2-N,N-Dialkylamino Benzoxazoles and Benzothiazoles. Tetrahedron, 56 (43). pp. 8567-8571. ISSN 0040-4020

Khalaf, A.I. and Pitt, A.R. and Scobie, M. and Suckling, C.J. and Urwin, J. and Waigh, R.D. and Young, S.C. and Fishleigh, R.V. and Fox, K.R. (2000) DNA Binding, Solubility, and Partitioning Characteristics of Extended Lexitropsins. Journal of Medicinal Chemistry, 43 (17). pp. 3257-3266. ISSN 0022-2623

Khalaf, A.I. and Pitt, A.R. and Scobie, M. and Suckling, C.J. and Urwin, J. and Waigh, R.D. and Young, S.C. and Fishleigh, R.V. and Wylie, W.A. (2000) The Synthesis of Some Head to Head Linked DNA Minor Groove Binders. International Journal of Chemical Research, 56 (29). pp. 5225-5239. ISSN 0975-3699

Khalaf, A.I. and Pitt, A.R. and Scobie, M. and Suckling, C.J. and Urwin, J. and Waigh, R.D. and Young, S.C. and Fishleigh, R.V. (2000) The synthesis of some indole-containing amino acids as linkers for the construction of DNA minor groove binders. International Journal of Chemical Research, 2000 (6). pp. 264-265. ISSN 0975-3699

Kennedy, A.R. and Khalaf, A.I. and Suckling, C.J. (2000) 3-Acetoxycyclohex-4-ene-1,2-di-carboxylic anhydride. Acta Crystallographica Section C: Crystal Structure Communications, 56 (6). e265-e266. ISSN 0108-2701

Khalaf, Abedawn I. and Linaza, Sabin and Pitt, Andrew R. and Stimson, William H. and Suckling, Colin J. (2000) On the specificity of reactions catalysed by the antibody H11. Tetrahedron, 56 (3). pp. 489-495. ISSN 0040-4020

Khalaf, Abedawn I. and Pitt, Andrew R. and Scobie, Martin and Suckling, Colin J. and Urwin, John and Waigh, Roger D. and Fishleigh, Robert V. and Young, Stephen C. (2000) Synthesis of novel DNA binding agents: indole-containing analogs of bis-netropsin. International Journal of Chemical Research (6). pp. 264-265. ISSN 0975-3699

Kennedy, Alan and Khalaf, Abedawn I. and Pitt, Andrew P. and Scobie, Martin and Suckling, Colin J. and Urwin, John and Waigh, Roger D. and Young, Stephen C. (1999) Methyl 2-amino-4-(methoxymethyl)thiazole-5-carboxylate. Acta Crystallographica Section C: Crystal Structure Communications, C55 (7). ii, IUC9900072. ISSN 0108-2701

Bennett, S.R. and Kennedy, A.R. and Khalaf, A.I. (1998) 2,8-Dimethylphenoxathiin-10-oxide. Acta Crystallographica Section C: Crystal Structure Communications, 54 (10). pp. 1511-1513. ISSN 0108-2701

Kennedy, A.R. and Khalaf, A.I. (1997) N,N-diacetyl-2,5-dimethyl-6-nitroaniline. Acta Crystallographica Section C: Crystal Structure Communications, 53 (6). pp. 744-746. ISSN 0108-2701

Booker-Milburn, Kevin I. and Dunkin, Ian R. and Kelly, Frances C. and Khalaf, Abedawn I. and Learmonth, David A. and Proctor, George R. and Scopes, David I. C. (1997) Azabenzocycloheptenones. Part 20. Synthesis and utilisation of 4-amino-1,2,3,4-tetrahydro-1(1H)-benzazepines. Journal of the Chemical Society, Perkin Transactions 1 (21). pp. 3261-3274. ISSN 1472-7781

Khalaf, Abedawn I. and Proctor, George R. and Suckling, Colin J. and Bence, Laura H. and Irvine, June I. and Stimson, William H. (1992) Remarkably efficient hydrolysis of a 4-nitrophenyl ester by a catalytic antibody raised to an ammonium hapten. Journal of the Chemical Society, Perkin Transactions 1 (12). pp. 1475-1481. ISSN 1472-7781

Suckling, Colin J. and Tedford, Catriona M. and Proctor, George R. and Khalaf, Abedawn I. and Bence, Laura M. and Stimson, William H. (1991) Catalytic antibodies: a new window on protein chemistry. Ciba Foundation Symposium, 159 (Catal.). pp. 201-210. ISSN 0300-5208

Khalaf, Abedawn and Mustaffa, Mohammad S. and Ali, Ja'Afar H. and Al-Dulaymi, Ju'ma R. and Hashem, A. K. (1988) A novel method for the preparation of β,γ-unsaturated carbonyl compounds. Journal of the Iraqi Chemical Society, 13 (1). pp. 159-172. ISSN 0379-8321

Book Section

Suckling, C.J. and Waigh, R.D. and Khalaf, A.L. and Parkinson, J. and Hunter, I.S. (2003) Minor groove binders substituted by lipophilic groups. In: 19th International Congress on Heterocyclic Chemistry. Elsevier, p. 98. ISBN 0-080443-04-4

Patent

Khalaf, Abedawn (2008) Novel hydrophobic minor groove binders. .

Khalaf, Abedawn (2003) DNA Minor Groove Binders. .

This list was generated on Mon Dec 22 14:36:40 2014 GMT.